Quantification of enhancement in contrast ultrasound: a tool for monitoring of therapies in liver metastases

Krix, Martin

doi:10.1007/s10406-005-0172-z

Cited by 23 publications

(13 citation statements)

References 12 publications

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“…Another major indication to contrast enhanced ultrasonography is follow-up of patients undergoing conventional chemotheraphy associated with drugs that inhibit tumor angiogenesis, which are being currently introduced in the clinical practice. In these patients lesion detection can be particularly difficult at greyscale ultrasound [16], and antiangiogenic drugs are expected to produce reduced lesion vascularity that can be evaluated with contrast enhanced ultrasonography [34][35][36][37][38].…”

Section: Diagnostic Problemsmentioning

confidence: 99%

Detection of Liver Metastases with Contrast Enhanced Ultrasonography

Bertolotto¹,

Bartolotta²,

Belgrano³

et al. 2007

CMIR

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Detection of liver metastases is one of the most common problems in evaluating patients with primary neoplasms. Gray-scale and color Doppler ultrasonography have limited accuracy with a sensitivity ranging between 53% and 77%. Isoechoic metastases and nodules under 1 cm in size may not be detectable. Occasionally, non-metastatic liver lesions can be identified in neoplastic patients which must be correctly characterized.Microbubble contrast agents overcome many limitations of gray-scale ultrasonography to detect liver metastases and increase the possibility to differentiate them from other focal liver lesions. In this review article we discuss the current role of contrast enhanced ultrasonography in detection of liver metastases using specialized destructive and non-destructive modes. Using air-filled microbubbles and destructive modes the sensitivity of contrast enhanced ultrasonography to detect liver metastases ranges between 80% and 98%. The ease of use of the non-destructive approach makes it much more attractive and is particularly helpful for lesion characterization. An increasing number of studies is being published regarding the diagnostic performance of perfluorocarbon-or sulfur hexafluoride-filled microbubbles with non-destructive modes to detect liver metastases, and the general agreement is that sensitivity and specificity of the non-destructive modes approach those of the destructive approach and of helical CT.

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Section: Diagnostic Problemsmentioning

confidence: 99%

Detection of Liver Metastases with Contrast Enhanced Ultrasonography

Bertolotto¹,

Bartolotta²,

Belgrano³

et al. 2007

CMIR

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“…Contrast-enhanced ultrasonography (CEUS) perfusion imaging permits tissue hemodynamics imaging. Indeed, CEUS-derived time-acoustic intensity curves reflects the tissue-of-interest hemodynamics by measuring the changes of intensity of the harmonic frequencies versus time (Krix 2005). The majority of the previously published CEUS studies in patients with chronic diffuse liver disease places great emphasis on the hepatic artery-tovein time-acoustic intensity curves (Staub et al 2009;Searle et al 2008;Ridolfi et al 2007;Lim et al 2005;Blomley et al 2003;Albrecht et al 1999;Pedersen et al 2005).…”

Section: Introductionmentioning

confidence: 99%

Liver Contrast Enhanced Ultrasound Perfusion Imaging in the Evaluation of Chronic Hepatitis C Fibrosis: Preliminary Results

Orlacchio

Bolacchi

Petrella

et al. 2011

Ultrasound in Medicine & Biology

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Abstract-We wanted to determine whether liver contrast-enhanced ultrasound (CEUS)-derived peak signal intensity (PSI) and peak signal intensity/time (PIT) predict liver fibrosis in chronic hepatitis C (CHC). Fortynine patients with CHC (METAVIR classification) and 10 control subjects were included in the study. After a bolus of 2.4 mL SonoVue (Bracco Imaging, Milan, Italy) solution was injected into a peripheral vein, the right lobe of the liver containing the right portal vein was scanned in a transverse section. Two-dimensional sonography was performed using the Philips iU22 ultrasound system (Philips Healthcare, Best, the Netherlands). A 1.0-5.0-MHz (C5-1) wideband convex transducer was used, applying the following settings in all cases. Regions of interest were manually drawn over the right liver lobe and over the portal vein (PV). Liver parenchyma PSI (LPpsi) and PIT (LPpit), portal vein PSI (PVpsi) and PIT (PVpit) were automatically calculated. dPSI was defined as the difference between PVpsi and LPpsi. A significant correlation was observed between PA PSI and fibrosis scores. When patients were stratified according to their LPpsi, a significant difference was achieved only between patients with fibrosis score 0-1 vs. 2-3 and 2 vs. 4. Statistically significant differences between all fibrosis scores, except 0 vs. 1 and 3 vs. 4 were observed when dPSI was used to stratify patients. Overall diagnostic accuracy of LPpsi and dPSI measurement for severe fibrosis by area under the receiving operator characteristic curve analysis was, respectively, 0.87 and 0.88. We suggest that liver CEUS perfusion could have the potential to be used as a complementary tool for the evaluation of liver fibrosis. However, further large-scale studies are required to accurately assess its accuracy in the evaluation of liver fibrosis. (E-mail: aorlacchio@uniroma2.it) Ó 2011 World Federation for Ultrasound in Medicine & Biology.

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“…Much work in this field has attempted to quantify the amount of vascularisation or their anatomical arrangements, with varying degrees of success [22,42,51,87]. An intriguing development has been the use of TICs of the wash-in and wash-out of Fig.…”

Section: Other Organsmentioning

confidence: 99%