Quantification of gallbladder emptying in man using intestinal perfusion and ultrasonography: A prospective comparison of two methods

Kh, Holtermüller; Herzog, P.; Cölle, H

doi:10.1007/bf01476575

Cited by 6 publications

(3 citation statements)

References 8 publications

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“…The apparatus provides an automatic pla nimetry device. By rotation of the probe maximum gall bladder area was determined as a bidimensional parameter of gall bladder contraction [32,33]. …”

Section: (¡All Bladder Contractionmentioning

confidence: 99%

Effect of the Somatostatin Analogue Sandostatin (SMS 201–995) on Gastrointestinal, Pancreatic and Biliary Function and Hormone Release in Normal Men

et al. 1987

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The effect of the long-acting somatostatin analogue Sandostatin (SMS 201–995) on intestinal absorption and propagation (mouth-to-caecum transit time; MCTT), on pancreatic secretion and on gall bladder contraction after direct (secretin-pancreozymin test) and indirect stimulation (Lundh meal), and on meal-induced responses of seven gastrointestinal regulatory peptides has been investigated. In a double-blind cross-over study, 9 healthy volunteers completed two 7-day periods with subcutaneous injections of either placebo or 25 μg SMS 201–995 twice daily. Mean faecal fat excretion was increased to 19.2 g/ day and MCTT was three times longer during the SMS period. After duodenal infusion of a mixture containing D-galactose, D-xylose and triglycerides, SMS 201–995 significantly reduced the serum concentrations of D-galactose but increased serum levels of D-xylose. After 6 days of pretreatment, SMS 201–995 completely suppressed duodenal trypsin, lipase and bilirubin increases in response to endogenous stimulation by a Lundh meal. Concomitantly, cholecystokinin (CCK) release and gall bladder contraction were almost abolished. Compared with placebo, SMS 201–995 significantly diminished pancreatic amylase, trypsin and lipase output after stimulation with CCK, while the secretion of fluid and bicarbonate in response to secretin was unchanged. This inhibition of enzyme response was significantly more marked after a single injection of the analogue than after pretreatment for 7 days and did not reach the level of exocrine pancreatic insufficiency. CCK-induced gall bladder contraction was significantly inhibited by a single dose of 25 μg SMS 201–995 but not after 7 days of pretreatment with the somatostatin analogue.

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Section: (¡All Bladder Contractionmentioning

confidence: 99%

Effect of the Somatostatin Analogue Sandostatin (SMS 201–995) on Gastrointestinal, Pancreatic and Biliary Function and Hormone Release in Normal Men

et al. 1987

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“…The ultrasonic measurement of gallbladder volume is a well-established method and is especially suitable for repeated measurements because of the lack of radiation exposure. The specificity and reliability of this method have been proven to be sufficient for chronobiological experiments, as well as for pharmacological studies (16)(17)(18). The quantification of gallbladder volume using the Simpson formula is the most exact method available (15).…”

Section: Methodsmentioning

confidence: 99%

Circadian Variations in the Responsiveness of Human Gallbladder to Sulfated Mineral Water

Gutenbrunner

El-Cherid

Gehrke

et al. 2001

Chronobiology International

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It is well known that the intake of sulfate-containing natural mineral waters leads to contraction of the gallbladder, probably induced by the release of cholecystokinin (CCK). As early as 1959, there were some hints in the literature of circadian variations in gallbladder response; to find out whether this applies with sulfate as a stimulus, a pretest for basic information about gallbladder reaction to sulfate-containing mineral water was carried out on 19 healthy volunteers. On this basis, 15 healthy subjects of both sexes were then studied. After 6h of fasting, 500 mL of a sulfate-containing mineral water (2,800 mg SO4(2-)/L) were ingested within 5 min. The size of the gallbladder was registered ultrasonographically before and 15, 30, 60, and 120 min after drinking. The experiments were carried out seven times at different hours of the day for each volunteer. After the intake of the mineral water, the mean gallbladder size decreased significantly, followed by an increase after 60 min (P < .001). Significant circadian spontaneous variation in gallbladder size was detected (acrophase around 09:00; amplitude was 30.0% of daily average, P < .001). The contraction induced by the sulfate-containing water was most marked in the early morning hours and minimal around mid-day; the amplitude of this variation accounting for 29.0% of the daily average (P < .01). In contrast, the postdrinking relaxation was maximal around 18:00 and minimal around 9:00 (amplitude 38.5%. P < .001). These results show that the basal size of the gallbladder and its reaction to stimuli show a marked circadian variation: Whereas contractibility is maximal in the morning, dilatation is stronger in the afternoon.

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“…Zunächst konnten bei Validierung der eigenen funktionssonographischen Methode zur Überprüfung des Kontraktionsverhaltens der Gallenblase vergleichbare postprandiale Entleerungsfraktionen der Gallenblase bei Patienten mit erhaltener Duodenalpassage (gesunde Probanden, Patienten vor Gastrektomie) ermittelt werden wie in den Studien von Holtermüller [15], Palframan [18], Hahm [19] und Artiko [17]. Diese hatten die postprandiale Entleerungsfraktion der Gallenblase gesunder Probanden mit 40 -80 % angegeben.…”

Section: Diskussionunclassified

Untersuchungen zur Gallenblasenmotilität nach totaler Gastrektomie

Lindner¹,

Bauer²

2002

Viszeralchirurgie

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EinleitungDas Gallensteinleiden (Cholezystolithiasis) ist mit einer Häufig-keit von etwa 10 -15 % der Bevölkerung als Volkskrankheit zu bezeichnen [1]. Zudem ist die Cholezystolithiasis in den letzten Jahren zu einem wesentlichen gesundheitsökonomischen Problem geworden. Jährlich werden in Deutschland rund 80 000 Cholezystektomien durchgeführt, eine ganze Reihe von Gallensteinkomplikationen führt zu erheblicher Mortalität und Morbidität [2]. Die Cholezystolithiasis und die damit assoziierten Folgeer-

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Quantification of gallbladder emptying in man using intestinal perfusion and ultrasonography: A prospective comparison of two methods

Cited by 6 publications

References 8 publications

Effect of the Somatostatin Analogue Sandostatin (SMS 201–995) on Gastrointestinal, Pancreatic and Biliary Function and Hormone Release in Normal Men

Effect of the Somatostatin Analogue Sandostatin (SMS 201–995) on Gastrointestinal, Pancreatic and Biliary Function and Hormone Release in Normal Men

Circadian Variations in the Responsiveness of Human Gallbladder to Sulfated Mineral Water

Untersuchungen zur Gallenblasenmotilität nach totaler Gastrektomie

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