2020
DOI: 10.3390/ijms21176332
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Quantification of Iron Release from Native Ferritin and Magnetoferritin Induced by Vitamins B2 and C

Abstract: Various pathological processes in humans are associated with biogenic iron accumulation and the mineralization of iron oxide nanoparticles, especially magnetite. Ferritin has been proposed as a precursor to pathological magnetite mineralization. This study quantifies spectroscopically the release of ferrous ions from native ferritin and magnetoferritin as a model system for pathological ferritin in the presence of potent natural reducing agents (vitamins C and B2) over time. Ferrous cations are required for th… Show more

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Cited by 9 publications
(9 citation statements)
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“…The basic physicochemical characteristics (LF, D <HYDR> , ζ potential, polydispersity index-PDI) of the NF (horse spleen ferritin) and MF samples are shown in Table 1. The LF, D <HYDR> and ζ potential, including magnetization curves, of the mineral core reduction of NF and MF, induced by vitamins B 2 and C, have recently been published by this group [15]. Summarizing this earlier work, the hydrodynamic diameter D <HYDR> , determined by dynamic light scattering (DLS), has higher values of MF than NF, probably due to the aggregation of MFs as a consequence of their increased dipole-dipole interactions.…”
Section: Resultsmentioning
confidence: 77%
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“…The basic physicochemical characteristics (LF, D <HYDR> , ζ potential, polydispersity index-PDI) of the NF (horse spleen ferritin) and MF samples are shown in Table 1. The LF, D <HYDR> and ζ potential, including magnetization curves, of the mineral core reduction of NF and MF, induced by vitamins B 2 and C, have recently been published by this group [15]. Summarizing this earlier work, the hydrodynamic diameter D <HYDR> , determined by dynamic light scattering (DLS), has higher values of MF than NF, probably due to the aggregation of MFs as a consequence of their increased dipole-dipole interactions.…”
Section: Resultsmentioning
confidence: 77%
“…This process is hazardous, resulting in hydrogen peroxide overproduction and damage to antioxidants, including iron scavengers, peroxidases, and iron storage proteins, such as ferritin [13], which can lead to cancer [14]. From these studies, together with recent work on reduction of the ferritin nucleus [15], it appears that iron accumulation and mineralization is at least an accomplice of pathology. However, at present, it is still not known whether the formation of iron oxide aggregates is the cause or the result of pathology.…”
Section: Introductionmentioning
confidence: 99%
“…The iron core in the prepared MFer undergoes post-synthesis transformations associated with redox reactions in response to potential external effects of oxygen, changes in temperature or pH in the liquid state. This apparent lack of sensitivity causes the reactivity of MFer colloidal solutions, especially in interactions with other substances: vitamins [25], dangerous molecules such as polychlorinated biphenyls (PCBs) [49] or hydrogen peroxide (H 2 O 2 ) [50], schematically illustrated in Figure 8. Ascorbic acid and riboflavin, as electron donors, can reduce ferritin and the MFer iron core to ferrous ions [25].…”
Section: Critical Assessment Of Synthesis Technology and Application Potential Of Magnetoferritinmentioning
confidence: 99%
“…This apparent lack of sensitivity causes the reactivity of MFer colloidal solutions, especially in interactions with other substances: vitamins [25], dangerous molecules such as polychlorinated biphenyls (PCBs) [49] or hydrogen peroxide (H 2 O 2 ) [50], schematically illustrated in Figure 8. Ascorbic acid and riboflavin, as electron donors, can reduce ferritin and the MFer iron core to ferrous ions [25]. Vitamins can increase the bioavailability of iron for oral iron supplementation-based therapy by fine-tuning the optimal vitamin-to-iron ratio to reduce the harmful gastrointestinal side effects of iron [25,51].…”
Section: Critical Assessment Of Synthesis Technology and Application Potential Of Magnetoferritinmentioning
confidence: 99%
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