Quantification of lung water in heart failure using cardiovascular magnetic resonance imaging

Thompson, Richard B.; Chow, Kelvin; Pagano, Joseph J; Sekowski, Viktor; Michelakis, Evangelos D.; Tymchak, Wayne; Haykowsky, Mark J.; Oudit, Gavin Y.; Dyck, Jason R.B.; Kaul, Padma; Savu, Anamaria; Paterson, Ian

doi:10.1186/s12968-019-0567-y

Cited by 24 publications

(57 citation statements)

References 33 publications

(35 reference statements)

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“…The FLORET (Fermat looped, orthogonally encoded trajectories) 3D spiral UTE sequence offers improved efficiency as compared with radial trajectories for lung imaging, 19 but was not developed specifically for or validated for LWD estimation. Alternatively, spin‐echo approaches address the

T_{2}^{*}

signal loss in the lungs and can be used to estimate water density, 3 but with unwanted T 2 weighting and potential sensitivity to motion and flow artifacts as well as incomplete spatial coverage of the lungs.…”

Section: Introductionmentioning

confidence: 99%

Quantification of lung water density with UTE Yarnball MRI

Meadus

Stobbe

Grenier

et al. 2021

Magnetic Resonance in Med

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Purpose An efficient Yarnball ultrashort‐TE k‐space trajectory, in combination with an optimized pulse sequence design and automated image‐processing approach, is proposed for fast and quantitative imaging of water density in the lung parenchyma. Methods Three‐dimensional Yarnball k‐space trajectories (TE = 0.07 ms) were designed at 3 T for breath‐hold and free‐breathing navigator acquisitions targeting the lung parenchyma (full torso spatial coverage) with minimal T1 and T2∗ weighting. A composite of all solid tissues surrounding the lungs (muscle, liver, heart, blood pool) was used for user‐independent lung water density signal referencing and B1‐inhomogeneity correction needed for the calculation of relative lung water density images. Sponge phantom experiments were used to validate absolute water density quantification, and relative lung water density was evaluated in 10 healthy volunteers. Results Phantom experiments showed excellent agreement between sponge wet weight and imaging‐derived water density. Breath‐hold (13 seconds) and free‐breathing (~2 minutes) Yarnball acquisitions in volunteers (2.5‐mm isotropic resolution) had negligible artifacts and good lung parenchyma SNR (>10). Whole‐lung average relative lung water density values with fully automated analysis were 28.2 ± 1.9% and 28.6 ± 1.8% for breath‐hold and free‐breathing acquisitions, respectively, with good test–retest reproducibility (intraclass correlation coefficient = 0.86 and 0.95, respectively). Conclusions Quantitative lung water density imaging with an optimized Yarnball k‐space acquisition approach is possible in a breath‐hold or short free‐breathing study with automated signal referencing and segmentation.

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Section: Introductionmentioning

confidence: 99%

Quantification of lung water density with UTE Yarnball MRI

Meadus

Stobbe

Grenier

et al. 2021

Magnetic Resonance in Med

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“…The amount of late gadolinium enhancement outperforms current guideline-recommended criteria in the identification of patients with hypertrophic cardiomyopathy at risk of sudden cardiac death [9] Thompson et al Quantification of lung water in heart failure using cardiovascular magnetic resonance imaging [10] Dabir et al Multiparametric cardiovascular magnetic resonance imaging in acute myocarditis: a comparison of different measurement approaches [11] Holtackers et al Clinical value of dark-blood late gadolinium enhancement cardiovascular magnetic resonance without additional magnetization preparation [12] Shusterman et al High-energy external defibrillation and transcutaneous pacing during MRI: feasibility and safety [18] Thompson et al * Quantification of lung water in heart failure using cardiovascular magnetic resonance imaging [10] Walheim et al Multipoint 5D flow cardiovascular magnetic resonance-accelerated cardiac-and respiratory-motion resolved mapping of mean and turbulent velocities [19] website. Over 95% found value in the open-access format with 23% using JCMR as a source for CME and over 75% finding benefit of using the SCMR membership benefit for an 80% discount in the article publication fee (APC).…”

Section: Survey Results For Jcmrmentioning

confidence: 99%

“…The associate editors and I select the Pohost finalists (Table 4 ) and the entire editorial board votes on the top prize. At the 2020 SCMR annual meeting in Orlando, Florida, the 13 th Gerald M. Pohost Prize was awarded to Dr. Thompson for their manuscript” Quantification of lung water in heart failure using cardiovascular magnetic resonance imaging.” [ 10 ]. The Pohost Runner-up Prize was awarded to Dr. Nickander for “The relative contributions of myocardial perfusion, blood volume and extracellular volume to native T1 and native T2 at rest and during adenosine stress in normal physiology.…”

Section: Pohost and Pennell Awardsmentioning

confidence: 99%

“…2019 Jun 24;21(1):33 [ 17 ] Shusterman et al High-energy external defibrillation and transcutaneous pacing during MRI: feasibility and safety [ 18 ] Thompson et al . * Quantification of lung water in heart failure using cardiovascular magnetic resonance imaging [ 10 ] Walheim et al Multipoint 5D flow cardiovascular magnetic resonance—accelerated cardiac- and respiratory-motion resolved mapping of mean and turbulent velocities [ 19 ] * 2020 Pohost Award Winner ** 2020 Pohost Award Runner-up …”

Section: Pohost and Pennell Awardsmentioning

confidence: 99%

“…In late 2017, we introduced on-line CME credit for the benefit of our clinician readers. This program has been a great success and now includes over 30 manuscripts members including 6 in 2019 [7][8][9][10][11][12] (Table 3). See http:// scmr.peach newme dia.com/store /provi der/custo mpage .php?pagei d=20 for the entire listing.…”

Section: Continuing Medical Education (Cme) Jcmr Journal Clubmentioning

confidence: 99%

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2020 - State of our JCMR

Manning

2021

Journal of Cardiovascular Magnetic Resonance

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There were 79 articles published in the Journal of Cardiovascular Magnetic Resonance (JCMR) in 2019, including 65 original research papers, 2 reviews, 8 technical notes, 1 Society for Cardiovascular Magnetic Resonacne (SCMR) guideline, and 3 corrections. The volume was down slightly from 2018 (n = 89) with a corresponding 5.5% increase in manuscript submissions from 345 to 366. This led to a slight decrease in the acceptance rate from 25 to 22%. The quality of the submissions continues to be high. The 2019 JCMR Impact Factor (which is published in June 2020) increased from 5.07 to 5.36. The 2020 impact factor means that on average, each JCMR published in 2017 and 2018 was cited 5.36 times in 2019. Our 5 year impact factor was 5.2. We are now finishing the 13th year of JCMR as an open-access publication with BMC. As outlined in this report, the Open-Access system has dramatically increased the reading and citation of JCMR publications. I hope that our authors will continue to send their very best, high quality manuscripts for JCMR consideration and that our readers will continue to look to JCMR for the very best/state-of-the-art publications in our field. It takes a village to run a journal. JCMR is blessed to have very dedicated Associate Editors, Guest Editors, and Reviewers. I thank each of them for their efforts to ensure that the review process occurs in a timely and responsible manner. These efforts have allowed the JCMR to continue as the premier journal of our field. My role, and the entire process would not be possible without the dedication and efforts of our managing editor, Diana Gethers (who will leaving the journal in the coming months) and our assistant managing editor, Jennifer Rodriguez, who has agreed to increase her reponsibilities. Finally, I thank you for entrusting me with the editorship of the JCMR. As I begin my 5th year as your editor-in-chief, please know that I fully recognize we are not perfect in our review process. We try our best to objectively assess every submission in a timely manner, but sometimes don't get it “right.” The editorial process is a tremendously fulfilling experience for me. The opportunity to review manuscripts that reflect the best in our field remains a great joy and a highlight of my week!

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Quantitative fluid overload in severe aortic stenosis refines cardiac damage and associates with worse outcomes

Halavina,

Koschutnik,

Donà

et al. 2023

European J of Heart Fail

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AimsCardiac decompensation in aortic stenosis (AS) involves extra‐valvular cardiac damage and progressive fluid overload (FO). FO can be objectively quantified using bioimpedance spectroscopy. We aimed to assess the prognostic value of FO beyond established damage markers to guide risk stratification.Methods and resultsConsecutive patients with severe AS scheduled for transcatheter aortic valve implantation (TAVI) underwent prospective risk assessment with bioimpedance spectroscopy (BIS) and echocardiography. FO by BIS was defined as ≥1.0 L (0.0 L = euvolaemia). The extent of cardiac damage was assessed by echocardiography according to an established staging classification. Right‐sided cardiac damage (rCD) was defined as pulmonary vasculature/tricuspid/right ventricular damage. Hospitalization for heart failure (HHF) and/or death served as primary endpoint. In total, 880 patients (81 ± 7 years, 47% female) undergoing TAVI were included and 360 (41%) had FO. Clinical examination in patients with FO was unremarkable for congestion signs in >50%. A quarter had FO but no rCD (FO+/rCD−). FO+/rCD+ had the highest damage markers, including N‐terminal pro‐B‐type natriuretic peptide (NT‐proBNP) levels. After 2.4 ± 1.0 years of follow‐up, 236 patients (27%) had reached the primary endpoint (29 HHF, 194 deaths, 13 both). Quantitatively, every 1.0 L increase in bioimpedance was associated with a 13% increase in event hazard (adjusted hazard ratio 1.13, 95% confidence interval 1.06–1.22, p < 0.001). FO provided incremental prognostic value to traditional risk markers (NT‐proBNP, EuroSCORE II, damage on echocardiography). Stratification according to FO and rCD yielded worse outcomes for FO+/rCD+ and FO+/rCD−, but not FO−/rCD+, compared to FO−/rCD−.ConclusionQuantitative FO in patients with severe AS improves risk prediction of worse post‐interventional outcomes compared to traditional risk assessment.

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Quantification of lung water in heart failure using cardiovascular magnetic resonance imaging

Cited by 24 publications

References 33 publications

Quantification of lung water density with UTE Yarnball MRI

Quantification of lung water density with UTE Yarnball MRI

2020 - State of our JCMR

Quantitative fluid overload in severe aortic stenosis refines cardiac damage and associates with worse outcomes

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