Quantification of methadone, buprenorphine, naloxone, opioids, and their derivates in whole blood by liquid chromatography-high-resolution mass spectrometry: Analysis of their involvement in fatal forensic cases

Féliu, Catherine; Konecki, Céline; Binet, Laurent; Vautier, Damien; Haudecoeur, Cyril; Oget, Olivier; Fouley, Aurélie; Marty, Hélène; Gozalo, Claire; Cazaubon, Yoann; Djerada, Zoubir

doi:10.1016/j.jchromb.2020.122226

Cited by 16 publications

(5 citation statements)

References 31 publications

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“…This rapid and automatable method is a potential tool for routine quantification of BUP and its metabolites. Nevertheless, the most commonly employed sample pretreatment for the monitoring of BUP, MTD and their metabolites in biological matrices are liquid-liquid extraction (LLE) [18][19][20][21][22][23]26,40,47,49,50,[52][53][54]56,60,61,63,65,68,69,71,74,76,77,80,[88][89][90][91][92] and solid-phase extraction (SPE) [7,24,28,38,41,[43][44][45][46]48,55,68,72,73,75,[93][94][95]. The major benefits of LLE are its simplicity a...…”

Section: Sample Pretreatmentmentioning

confidence: 99%

“…Table 1 summarizes the details based on the use of LC techniques utilized for BUP and MTD measurement. LC can be coupled with ultraviolet (UV) [40][41][42][43]54], photodiode array detector (PAD) [40], fluorescence (FL) and electrochemical (EC) [29,38] MS detection [7,13,15,18,[23][24][25][26][27][28]49,50,52,56,[60][61][62]64,65,[68][69][70][71][72][73]88]. Reversed-phase columns (C 18 or C 8 columns) with spherical sorbent particles are popular for the determination of BUP, MTD and their metabolites.…”

Section: Liquid Chromatography Hyphenated Techniquesmentioning

confidence: 99%

“…The fast UHPLC separation can be utilized to monitor the multi-analyte mixtures in biological samples. Application of UHPLC-HRMS technique for the measurement of 16 opioids and derivatives, including BUP, NBUP, MTD and EDDP after LLE sample preparation with zinc sulfate, methanol and acetonitrile was developed by Feliu et al [61]. The method required only 100 µL of the blood sample.…”

Section: Liquid Chromatography Hyphenated Techniquesmentioning

confidence: 99%

“…Different biological specimens including urine [7,, plasma [13,20,21,35,38,40,[42][43][44][45][46][47][48][49][50][51][52][53][54][55], serum [30,[56][57][58][59], blood [15,18,22,49,[60][61][62][63], nails [64], oral fluid [17,31,55,[65][66][67][68][69], hair [47,[70][71][72], tissue [73,74] and exhaled breath condensate [75,76] have been used for the measurement of BUP, MTD and their metabo...…”

Section: Introductionmentioning

confidence: 99%

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Analytical Approaches for the Determination of Buprenorphine, Methadone and Their Metabolites in Biological Matrices

Shan¹,

Cao²,

Yang³

2022

Molecules

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The abuse of buprenorphine and methadone has grown into a rising worldwide issue. After their consumption, buprenorphine, methadone and their metabolites can be found in the human organism. Due to the difficulty in the assessment of these compounds by routine drug screening, the importance of developing highly sensitive analytical approaches is undeniable. Liquid chromatography tandem mass spectrometry is the preferable technique for the determination of buprenorphine, methadone and their metabolites in biological matrices including urine, plasma, nails or oral fluids. This research aims to review a critical discussion of the latest trends for the monitoring of buprenorphine, methadone and their metabolites in various biological specimens.

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Section: Sample Pretreatmentmentioning

confidence: 99%

Section: Liquid Chromatography Hyphenated Techniquesmentioning

confidence: 99%

Section: Liquid Chromatography Hyphenated Techniquesmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Analytical Approaches for the Determination of Buprenorphine, Methadone and Their Metabolites in Biological Matrices

Shan¹,

Cao²,

Yang³

2022

Molecules

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“…In the last decades, researchers have developed a variety of methods for the analysis of MOR and MET, such as high-performance liquid chromatography, supercritical fluid chromatography, gas chromatography coupled with mass spectroscopy, chemiluminescence, spectrophotometry, which are generally time-consuming, prohibitively expensive, complicated, and often require pretreatment 8 – 14 . Electrochemical techniques are emerging as promising alternative methods for pharmaceutical analysis because of their rapid results, simple operation, accuracy, and cost-effectiveness 15 .…”

Section: Introductionmentioning

confidence: 99%

Simultaneous electrochemical determination of morphine and methadone by using CMK-5 mesoporous carbon and multivariate calibration

Habibi

Ghasemi

Badiei

et al. 2022

Sci Rep

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For the first time, a sensitive electrochemical sensor using a glassy carbon electrode modified with CMK-5 Ordered mesoporous carbon was fabricated for simultaneous analysis of morphine and methadone. Modern electrochemical FFT-SWV techniques and partial least-squares as a multivariable analysis were used in this method. CMK-5 nanostructures were characterized by field emission scanning electron microscopy, transmission electron microscopy, X-ray diffraction analysis, and Raman spectroscopy. Variables such as accumulation time and pH for the proposed sensor were optimized before quantitative analysis. To train the proposed sensor, standard mixtures of morphine (MOR), and methadone (MET) were prepared in the established linear ranges of the analyzes. The results obtained from training samples were used for PLS modeling. The efficiency of the model was determined using test and real matrix samples. The root mean square error of prediction and the squared correlation coefficients (R2p) for MET and MOR were estimated to be 0.00772 and 0.00892 and 0.948 to 0.990, respectively. The recoveries in urine samples were reported to be 97.0 and 105.6% for both MOR and MET, respectively.

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Electrochemical sensor based on glassy carbon electrode modified by polymelamine formaldehyde/graphene oxide nanocomposite for ultrasensitive detection of oxycodone

et al. 2021

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Quantification of methadone, buprenorphine, naloxone, opioids, and their derivates in whole blood by liquid chromatography-high-resolution mass spectrometry: Analysis of their involvement in fatal forensic cases

Cited by 16 publications

References 31 publications

Analytical Approaches for the Determination of Buprenorphine, Methadone and Their Metabolites in Biological Matrices

Analytical Approaches for the Determination of Buprenorphine, Methadone and Their Metabolites in Biological Matrices

Simultaneous electrochemical determination of morphine and methadone by using CMK-5 mesoporous carbon and multivariate calibration

Electrochemical sensor based on glassy carbon electrode modified by polymelamine formaldehyde/graphene oxide nanocomposite for ultrasensitive detection of oxycodone

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