Quantification of moxifloxacin in urine using surface-enhanced Raman spectroscopy (SERS) and multivariate curve resolution on a nanostructured gold surface

Mamián-López, Mónica B.; Poppi, Ronei J.

doi:10.1007/s00216-013-7200-y

Cited by 42 publications

(22 citation statements)

References 28 publications

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“…Consequently, ways to overcome these issues should be sought. Urine and its constituents have been analyzed by SERS spectroscopy on more than one occasion [32,33]. The information about the components of interest was retrieved by applying mathematical procedure -multivariate curve resolution-alternating least squares (MCR-ALS) algorithm.…”

Section: Resultsmentioning

confidence: 99%

Application of SERS spectroscopy for detection of trace components in urinary deposits

et al. 2014

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Surface-enhanced Raman scattering (SERS) spectroscopy can be a useful tool in regard to disease diagnosis and prevention. Advantage of SERS over conventional Raman spectroscopy is its significantly increased signal (up to factor of 10 6 -10 8 ) which allows detection of trace amounts of substances in the sample. So far, this technique is successfully used for analysis of food, pieces of art and various biochemical/biomedical samples. In this work, we survey the possibility of applying SERS spectroscopy for detection of trace components in urinary deposits. Early discovery together with the identification of the exact chemical composition of urinary sediments could be crucial for taking appropriate preventive measures that inhibit kidney stone formation or growth processes. In this initial study, SERS spectra (excitation wavelength -1064 nm) of main components of urinary deposits (calcium oxalate, uric acid, cystine, etc.) were recorded by using silver (Ag) colloid. Spectra of 10 -3 -10 -5 M solutions were obtained. While no/small Raman signal was detected without the Ag colloid, characteristic peaks of the substances could be clearly separated in the SERS spectra. This suggests that even small amounts of the components could be detected and taken into account while determining the type of kidney stone forming in the urinary system. We found for the first time that trace amounts of components constituting urinary deposits could be detected by SERS spectroscopy. In the future study, the analysis of centrifuged urine samples will be carried out.

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Section: Resultsmentioning

confidence: 99%

Application of SERS spectroscopy for detection of trace components in urinary deposits

et al. 2014

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“…Marqués 24) studied the acid-base behavior of adenine, adenosine 3,5-cyclic monophosphate and poly(adenylic) acid at 37°C by a spectrophotometric titration in acetonitrile-water mixtures. Nigam et al 25) used MCR-ALS and ultraviolet 26) adopted standard addition method in conjunction with MCR-ALS in order to eliminate the matrix effect and to isolate the spectral contribution of analyte. They used nanostructured gold as a surface-enhanced Raman scattering signal enhancer for kinetic analysis.…”

Section: Resultsmentioning

confidence: 99%

Quantification of Pharmaceutical Compounds Based on Powder X-Ray Diffraction with Chemometrics

Otsuka

Itô

Matsumura

et al. 2016

CHEMICAL & PHARMACEUTICAL BULLETIN

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We propose an approach for the simultaneous determination of multiple components in pharmaceutical mixed powder based on powder X-ray diffraction (PXRD) method coupled with chemometrics. Caffeine anhydrate, acetaminophen and lactose monohydrate were mixed at various ratios. The samples were analyzed by PXRD method in the ranges of 2θ 5.00-30.0 and 35.0-45.0 degrees. Obtained diffractograms were analyzed by conventional peak intensity method, multi curve resolution (MCR)-alternating least squares (ALS) method and partial least squares (PLS) method. Constructed PLS models can most accurately predict the concentrations among different methods used. Each regression vector of PLS correlates not only to the compound of interest but also to the coexisting compounds. The combination of PXRD and PLS methods is concluded to be powerful approach for analyzing multi components in pharmaceutical formulations.Key words powder X-ray diffraction; partial least square; pharmaceutical formulationThe polymorphs and pseudo-polymorphs (hydrates and solvates) of pharmaceuticals exhibit different physicochemical properties such as solubility, dissolution rate, stability and hygroscopicity. These properties strongly relate to the pharmaceutical properties in their dosage forms such as specific bioavailability, efficacy, stability and toxicity.1) Pharmaceutical regulations are, therefore, required for producing appropriate bulk drugs, the crystalline modifications of which (i.e., polymorphism) are well specified or precisely controlled. 2)Powder X-ray diffraction (PXRD) analysis is the most frequently used method for identifying crystalline modifications and for determining their contents in bulk powders.3) Any crystals have their own PXRD patterns. Pharmaceutical formulations are, in general, composed of multiple components including excipients. PXRD is, therefore, useful to identify crystalline compounds in the formulation and to determine their amounts in a non-contact and non-destructive fashion. 4,5) However, PXRD method has large relative errors, typically around ±5%. Such shortcoming of PXRD method is serious when two or more components having broad and overlapping X-ray diffraction peaks are contained in one formulation.Regulatory authorities such as the U.S. Food and Drug Administration and the International Conference on Harmonization have requested to use Process Analytical Technology (PAT) in order to reduce the production risk of inferior pharmaceuticals.6) Since the introduction of guidelines for PAT, online and real-time analysis have increasingly been accepted in pharmaceutical industry as a tool for monitoring and controlling manufacturing process. Non-contact methods, such as PXRD analysis, near infrared (NIR) spectroscopy and terahertz spectroscopy have been paid attention as important tools for PAT. 6) Chemoinformatics are employed by pre-formulation scientists for the quantitative and qualitative analyses of NIR because they can provide ideal means for extracting quantitative information from complex spectra of mult...

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“…5b shows typical chromatogram obtained after in-tube SPME of spiked urine sample (Urine 1), which appearance of new sharp peak of the drug is obvious in spiked urine sample. Mamian-Lopez and Poppi reported that moxifloxacin is in the range of 700 to 1500 µg mL -1 in urine 22 . By our method these concentration can be easily detected.…”

Section: Analysis Of Urine Samplesmentioning

confidence: 99%

On-line microextraction of moxifloxacin using Fe₃O₄ nanoparticle-packed in-tube SPME

2015

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In the current study, an in-tube solid phase microextraction (SPME) approach based on Fe3O4 nanoparticles packed tube for microextraction and detection of moxifloxacin has been reported. In this regard, the Fe3O4 nanoparticles (NPs) were prepared by a batch synthesis and were introduced into a stainless steel tube by a syringe. Afterward, a strong magnet was placed around the tube, so that the Fe3O4 NPs were retained in the tube and the tube was used in the in-tube SPME-HPLC for the analysis of moxifloxacin in urine samples, which sodium dodecyl sulfate (SDS) was used as bridging agent between the Fe3O4 NPs and moxifloxacin. The operational conditions such as uptake and release times, flow rate and pH of solution were investigated and optimized. According to our findings, the linear range and detection limit (S/N = 3) were 0.1-5000 and 0.03 µg L −1 , respectively. Simplicity and facile automation, rapid analysis, high sensitivity, wide linear range, and fully sorbent collection after analysis are the main advantages of the method.

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Quantification of moxifloxacin in urine using surface-enhanced Raman spectroscopy (SERS) and multivariate curve resolution on a nanostructured gold surface

Cited by 42 publications

References 28 publications

Application of SERS spectroscopy for detection of trace components in urinary deposits

Application of SERS spectroscopy for detection of trace components in urinary deposits

Quantification of Pharmaceutical Compounds Based on Powder X-Ray Diffraction with Chemometrics

On-line microextraction of moxifloxacin using Fe₃O₄ nanoparticle-packed in-tube SPME

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Quantification of moxifloxacin in urine using surface-enhanced Raman spectroscopy (SERS) and multivariate curve resolution on a nanostructured gold surface

Cited by 42 publications

References 28 publications

Application of SERS spectroscopy for detection of trace components in urinary deposits

Application of SERS spectroscopy for detection of trace components in urinary deposits

Quantification of Pharmaceutical Compounds Based on Powder X-Ray Diffraction with Chemometrics

On-line microextraction of moxifloxacin using Fe3O4 nanoparticle-packed in-tube SPME

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On-line microextraction of moxifloxacin using Fe₃O₄ nanoparticle-packed in-tube SPME