Quantification of myocardial blood flow and myocardial flow reserve with SPECT imaging technique

Khaing, Thet; Raymond, Ching Chiew Wong; Chan, Woon‐Khiong; Chen, Hao; Wong, Siong Sung

doi:10.1007/s12350-017-1152-0

Cited by 4 publications

(2 citation statements)

References 3 publications

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“…Both techniques enable whole body imaging of molecular targets/processes with high sensitivity. SPECT is mainly used for whole body bone imaging [ 78 – 80 ], myocardial blood flow imaging [ 81 – 84 ], cerebral blood flow imaging [ 85 – 89 ], and thyroid imaging [ 90 – 95 ]. PET is mainly used to detect dynamic changes in the metabolic function of substances (or drugs) in the human body, and it widely used for the nervous system, the cardiovascular system, and the oncology [ 96 – 101 ].…”

Section: Molecular Imaging Modelsmentioning

confidence: 99%

Multimodal Molecular Imaging: Current Status and Future Directions

Shu

2018

Contrast Media & Molecular Imaging

108

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Molecular imaging has emerged at the end of the last century as an interdisciplinary method involving in vivo imaging and molecular biology aiming at identifying living biological processes at a cellular and molecular level in a noninvasive manner. It has a profound role in determining disease changes and facilitating drug research and development, thus creating new medical modalities to monitor human health. At present, a variety of different molecular imaging techniques have their advantages, disadvantages, and limitations. In order to overcome these shortcomings, researchers combine two or more detection techniques to create a new imaging mode, such as multimodal molecular imaging, to obtain a better result and more information regarding monitoring, diagnosis, and treatment. In this review, we first describe the classic molecular imaging technology and its key advantages, and then, we offer some of the latest multimodal molecular imaging modes. Finally, we summarize the great challenges, the future development, and the great potential in this field.

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Section: Molecular Imaging Modelsmentioning

confidence: 99%

Multimodal Molecular Imaging: Current Status and Future Directions

Shu

2018

Contrast Media & Molecular Imaging

108

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“…Furthermore, increased LV strain in non-ischemic myocardium was also revealed under adenosine stress against the resting state. In addition, myocardial flow reserve (MFR) derived from 13 Nammonia PET constitutes the stress to resting ratio of myocardial blood flows and represents the relative reserve of the coronary circulation [2][3][4][5][6]. The MFR can be modeled as the 17 segments of the LV myocardium and can be displayed as a color map to obtain the regional MFR for each coronary artery territory as the right coronary artery (RCA), left anterior descending artery (LAD), and left circumflex coronary artery (LCx).…”

Section: Introductionmentioning

confidence: 99%

13 N-ammonia PET-derived right ventricular longitudinal strain and myocardial flow reserve in right coronary artery disease

Kawakubo

Nagao

Yamamoto

et al. 2021

Eur J Nucl Med Mol Imaging

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Purpose:We developed a feature-tracking algorithm for use with electrocardiography-gated high-resolution 13 N-ammonia positron emission tomography (PET) imaging, and we hypothesized it could be used to clarify the association between right ventricular (RV) longitudinal strain (LS) and right coronary artery (RCA) ischemia. The aim of this study was to investigate the association between the reduction of regional myocardial flow reserve (MFR) in RCA territories and PET-derived LS of the RV free wall. Methods: Ninety-three patients with coronary artery stenosis > 50%, diagnosed by coronary computed tomography angiography, and 10 controls were retrospectively analyzed. RV-LS in the free wall was measured by a feature-tracking technique on the resting and stressed 13 N-ammonia PET images of horizontal long-axis slices. The patients were sub-grouped according to regional MFR values at the territories of RCA, left anterior descending artery (LAD), and left circumflex coronary artery (LCx): RCA-MFR<2.0 [n=34], RCA-MFR 2.0 but MFR<2.0 at LAD or LCx territories [n=11], and for all territories [n=48]. Stress and resting RV-LS were compared in each of the four groups. Multiple comparisons of RV-LS among the four groups were performed in the stress and resting state.Results: Decreased stress RV-LS in patients with an RCA-MFR<2.0 was observed. In the patients with for all territories, the stressed RV-LS was significantly increased compared to that in the resting state. Significantly decreased RV free-wall LS during adenosine stress in patients with RCA-MFR<2.0 was observed in the other three groups. Conclusions:We measured RV myocardial LS using feature tracking in cine imaging of 13 N-ammonia PET.The results of this study suggest that PET-derived stressed RV-LS is useful for detecting reduced RV myocardial motion due to ischemia in the RCA territory.

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Assessment of Myocardial Blood Flow with Cardiac PET Perfusion Imaging

Heller

2024

Handbook of Nuclear Cardiology

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Quantification of myocardial blood flow and myocardial flow reserve with SPECT imaging technique

Cited by 4 publications

References 3 publications

Multimodal Molecular Imaging: Current Status and Future Directions

Multimodal Molecular Imaging: Current Status and Future Directions

13 N-ammonia PET-derived right ventricular longitudinal strain and myocardial flow reserve in right coronary artery disease

Assessment of Myocardial Blood Flow with Cardiac PET Perfusion Imaging

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