Quantification of myocardial perhsion by MRI after coronary occlusion

Vallée, Jean‐Paul; Sostman, Henry Dirk; MacFall, James R.; DeGrado, Timothy R.; Zhang, Jian; Sebbag, Laurent; Cobb, F. R.; Wheeler, Ted; Hedlund, L W; Turkington, T.G.; Spritzer, Charles E.; Coleman, Robert E.

doi:10.1002/mrm.1910400215

Cited by 48 publications

(42 citation statements)

References 35 publications

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“…An advantage over PET is that no isotopes are needed (Vallé et al 1998). The temporal and spatial resolution has also been suggested to be slightly better than that with PET (Vallé et al 1998). Magnetic resonance imaging equipment is also more readily available than PET (Vallé et al 1998).…”

Section: Magnetic Resonance Velocity Imagingmentioning

confidence: 99%

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Limb and skeletal muscle blood flow measurements at rest and during exercise in human subjects

Rådegran

1999

Proc. Nutr. Soc.

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Abbreviations: ∆f, Doppler frequency shift that occurs as transmitted sound waves of a specific frequency f are reflected by erythrocytes; ICG, indo-cyanine green; NIRS, near i.r. spectroscopy; PET, positron emission tomography. The aim of the present review is to present techniques used for measuring blood flow in human subjects and advice as to when they may be applicable. Since blood flow is required to estimate substrate fluxes, energy turnover and metabolic rate of skeletal muscle, accurate measurements of blood flow are of extreme importance. Several techniques have therefore been developed to enable estimates to be made of the arterial inflow to, venous outflow from, or local blood flow within the muscle. Regional measurements have been performed using electromagnetic flow meters, plethysmography, indicator methods (e.g. thermodilution and indo-cyanine green dye infusion), ultrasound Doppler, and magnetic resonance velocity imaging. Local estimates have been made using 133 Xe clearance, microdialysis, near i.r. spectroscopy, positron emission tomography and laser Doppler. In principle, the aim of the study, the type of interventions and the limitations of each technique determine which method may be most appropriate. Ultrasound Doppler and continuous indo-cyanine green dye infusion gives the most accurate limb blood flow measurements at rest. Moreover, the ultrasound Doppler is unique, as it does not demand a steadystate, and because its high temporal resolution allows detection of normal physiological variations as well as continuous measurements during transitional states such as at onset of and in recovery from exercise. During steady-state exercise thermodilution can be used in addition to indo-cyanine green dye infusion and ultrasound Doppler, where the latter is restricted to exercise modes with a fixed vessel position. Magnetic resonance velocity imaging may in addition be used to determine blood flow within deep single vessels. Positron emission tomography seems to be the most promising tool for local skeletal muscle blood-flow measurements in relation to metabolic activity, although the mode and intensity of exercise will be restricted by the apparatus design.

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Section: Magnetic Resonance Velocity Imagingmentioning

confidence: 99%

“…The temporal and spatial resolution has also been suggested to be slightly better than that with PET (Vallé et al 1998). Magnetic resonance imaging equipment is also more readily available than PET (Vallé et al 1998). However, the equipment and running costs are very high.…”

Section: Magnetic Resonance Velocity Imagingmentioning

confidence: 99%

Limb and skeletal muscle blood flow measurements at rest and during exercise in human subjects

Rådegran

1999

Proc. Nutr. Soc.

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“…There is now growing evidence that K i in particular provides valuable and clinically useful information related to perfusion (7)(8)(9)(10)(11)(12)15). For example, it has been shown previously that infusion of dipyridamole in humans resulted in an increase of K i by a factor of 2-3 in the heart of healthy subjects.…”

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confidence: 99%

Quantification of the effect of water exchange in dynamic contrast MRI perfusion measurements in the brain and heart

Larsson

Rosenbaum

Fritz‐Hansen

2001

Magnetic Resonance in Med

103

125

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Measurement of myocardial and brain perfusion when using exogenous contrast agents (CAs) such as gadolinium-DTPA (Gd-DTPA) and MRI is affected by the diffusion of water between compartments. This water exchange may have an impact on signal enhancement, or, equivalently, on the longitudinal relaxation rate, and could therefore cause a systematic error in the calculation of perfusion (F) or the perfusionrelated parameter, the unidirectional influx constant over the capillary membranes (K i ). The aim of this study was to quantify the effect of water exchange on estimated perfusion (F or K i ) by using a realistic simulation. These results were verified by in vivo studies of the heart and brain in humans. The conclusion is that water exchange between the vascular and extravascular extracellular space has no effect on K i estimation in the myocardium when a normal dose of Gd-DTPA is used. Water exchange can have a significant effect on perfusion estimation (F) in the brain when using Gd-DTPA, where it acts as an intravascular contrast agent. Measurement of perfusion when using exogenous contrast agents (CAs) and MRI is affected by the diffusion of water between compartments. Several studies have indicated that this could affect the results of such perfusion measurements (1-6). However, contrast-enhanced MRI using T 1 -weighted imaging has been developed in order to measure perfusion or perfusion-related parameters of the heart in vivo without explicitly considering the effect of water exchange. Models of perfusion in animals and humans when using extravascular CAs such as gadolinium-DTPA (Gd-DTPA) or intravascular CA have been presented (7-12). These measurements are often based on inversion recovery turboFLASH (IR-turboFLASH) or saturation recovery turboFLASH (SAT-turboFLASH) imaging.Most of these studies measure the tissue enhancement curve and the arterial input function and rely on basic tracer kinetic models as formulated by Kety (13). In the ideal case, this approach gives the unidirectional influx constant K i (ml/100 g/min) for CA diffusion over the capillary membrane when extravascular CA is used and the perfusion F (ml/100 g/min) when intravascular CA is used. For extravascular CA, the perfusion and the unidirectional influx constant are related by K i ϭ EF (14), where E is the unidirectional extraction fraction in the first pass.There is now growing evidence that K i in particular provides valuable and clinically useful information related to perfusion (7-12,15). For example, it has been shown previously that infusion of dipyridamole in humans resulted in an increase of K i by a factor of 2-3 in the heart of healthy subjects. In patients with ischemic heart disease, K i was either unaffected or decreased after infusion of dipyridamole in areas supplied by an insufficient coronary artery (16,17).Many assumptions need to be investigated in order to clearly associate directly the MRI-determined K i with the physiological parameter, the unidirectional influx constant of the CA diffusion over the capillary mem...

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“…Time transit through a tissue can be estimated with a magnetic resonance (MR) first pass imaging technique and contrast media injection [1][2][3][4][5][6][7][8][9] . However, quantification of myocardial perfusion from the MRI remains a challenge.…”

Section: Introductionmentioning

confidence: 99%

Myocardial perfusion assessment by use of system identification method in a one-compartment model

Kocher

Daire

Thévenaz

et al. 2007

2007 29th Annual International Conference of the IEEE Engineering in Medicine and Biology Society

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Abstract-Cardiovascular magnetic resonance has been shown to provide high data quality for myocardial perfusion assessment. However, to analyze the perfusion data, some signal processing and modeling is needed to correct for motion related artifacts and limited spatial resolution. This study describes a method based on system identification, allowing, after a first step of image registration, to integrate and correct the partial volume effect in the myocardium perfusion quantification. This method is then applied to patients with coronary artery disease or hypertrophic obstructive cardiomyopathy.

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Quantification of myocardial perhsion by MRI after coronary occlusion

Cited by 48 publications

References 35 publications

Limb and skeletal muscle blood flow measurements at rest and during exercise in human subjects

Limb and skeletal muscle blood flow measurements at rest and during exercise in human subjects

Quantification of the effect of water exchange in dynamic contrast MRI perfusion measurements in the brain and heart

Myocardial perfusion assessment by use of system identification method in a one-compartment model

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