“…Also, the sex hormones in females are contributed regulating the lipid metabolism (Nikolic et al, 2016) and the homeostasis of glucose ) Hao et al,2015). The epidemiological studies demonstrated the status of menopause was influenced by the levels of estrogen (Pan et al, 2003) and is related to osteoporosis, urogenital atrophy, sexual dysfunction, psychiatric disorders, metabolic disorders, cardiovascular disease ,and obesity (Lobo et al, 2014;Utian and Wood ,2013;Archer et al,2015). T2DM consider a multigenic metabolic disturbance that happens in the various age categories as a result of environmental and genetic factors (Malecki and Klupa,2005).…”