2012
DOI: 10.1007/s00216-012-6277-z
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Quantification of p-cresol sulphate in human plasma by selected reaction monitoring

Abstract: Chronic renal failure patients accumulate in the blood molecules that are normally excreted into the urine. p-Cresol Sulphate (pCS), the most representative retained toxin, shows a high level of toxicity. Therefore, its quantification could represent a prediction factor to determine the risk of endothelial dysfunction and cardiovascular complication and response to the haemodialysis treatment. The aim of this study was to evaluate the suitability of the multiple reaction monitoring (MRM) technique in order to … Show more

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Cited by 28 publications
(22 citation statements)
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“…Normal total average serum/plasma concentrations of pCS reported, vary between 2.8 ± 1.7 mg/L (14.9 ± 9.0 µM) [ 12 ] and 6.6 ± 3.7 mg/L (35.1 ± 19.7 µM) [ 13 ] as determined in serum by ultra-performance liquid chromatography (UPLC) and UPLC-mass spectrometry (MS)-MS, respectively. In end-stage kidney disease (ESKD), concentrations of pCS are significantly increased with total average concentrations varying from 21.8 ± 12.4 mg/L (115.8 ± 65.9 µM) [ 14 ] to 106.9 ± 44.6 mg/L (568.0 ± 237.0 µM) [ 15 ], as quantified by UPLC in serum and LC-MS-MS in plasma, respectively.…”
Section: Characteristics Of P -Cresyl Sulfatementioning
confidence: 99%
“…Normal total average serum/plasma concentrations of pCS reported, vary between 2.8 ± 1.7 mg/L (14.9 ± 9.0 µM) [ 12 ] and 6.6 ± 3.7 mg/L (35.1 ± 19.7 µM) [ 13 ] as determined in serum by ultra-performance liquid chromatography (UPLC) and UPLC-mass spectrometry (MS)-MS, respectively. In end-stage kidney disease (ESKD), concentrations of pCS are significantly increased with total average concentrations varying from 21.8 ± 12.4 mg/L (115.8 ± 65.9 µM) [ 14 ] to 106.9 ± 44.6 mg/L (568.0 ± 237.0 µM) [ 15 ], as quantified by UPLC in serum and LC-MS-MS in plasma, respectively.…”
Section: Characteristics Of P -Cresyl Sulfatementioning
confidence: 99%
“…The average of PCS plasma concentration in healthy subjects varies between 14.9 µM (±9.0 µM) and 35.1 µM (±19.7 µM) [ 92 , 93 ]. However, this concentration significantly increases in CKD patients reaching 568.0 µM (±237.0 µM) quantified by LC-MS-MS, as PCS is mainly excreted by the kidneys via organic anion transporters OAT1 and OAT3 [ 94 , 95 ].…”
Section: The Role Of Uremic Toxin In Vascular Dysfunctionmentioning
confidence: 99%
“…For the synthesis of p CS ( 1 ), we started from the method [23] used by a number of authors [16,17,18,19,20,21,22]. Unfortunately, in our hand, this procedure [21,23] led exclusively to the sulfonation of the aromatic ring ( 2 ) instead of sulfation on the OH moiety ( 1 ).…”
Section: Resultsmentioning
confidence: 99%
“…When we started this work, p CS was hardly commercially available, so we decided to prepare and characterize authentic specimens for method set-up and validation. Synthetic approaches were tested; however, the results were different from those anticipated from the literature [16,17,18,19,20,21,22,23]. The necessity of unambiguous product characterization and reliable route for p CS sample preparation highlighted some novel facets of this deceivingly simple molecule.…”
Section: Introductionmentioning
confidence: 89%