Quantification of perfusion in murine myocardium: A retrospectively triggeredT₁-based ASL method using model-based reconstruction

Abstract

The proposed method is capable of producing quantitative perfusion maps on arbitrary positions in the heart cycle within a short measurement time. The method is robust against irregular breathing patterns and heart rate changes and can be implemented on all scanners.

Self‐navigation under non‐steady‐state conditions: Cardiac and respiratory self‐gating of inversion recovery snapshot FLASH acquisitions in mice

“…The results are similar for all healthy animals (see http://onlinelibrary.wiley.com/store/10.1002/mrm.26068/asset/supinfo/mrm26068-sup-0001-suppinfo1.pdf?v=1&s=c7f567e239f5e953e4fc453bffc1830965e9d134 and Table ). The proposed workflow also enables the reconstruction of T 1 maps at different cardiac phases, similar to the method proposed previously (http://onlinelibrary.wiley.com/store/10.1002/mrm.26068/asset/supinfo/mrm26068-sup-0001-suppinfo1.pdf?v=1&s=c7f567e239f5e953e4fc453bffc1830965e9d134.). Figure IIa displays end‐diastolic T 1 maps of the post‐MI mouse (for an analysis of the self‐gating signals, see http://onlinelibrary.wiley.com/store/10.1002/mrm.26068/asset/supinfo/mrm26068-sup-0001-suppinfo1.pdf?v=1&s=c7f567e239f5e953e4fc453bffc1830965e9d134).…”

“…Both the self‐gating signal and the ECG reference are used for cardiac synchronization. Trigger time stamps and the cardiac phases were determined using the algorithm described previously . For the analysis of the self‐gating signal the nearest neighbor intervals between the trigger time stamps were correlated with the ECG signal.…”

“…Both techniques, however, strongly impede the use of self‐gating as the center k‐space signal is modulated by the transient to the steady state. Recently, a cartesian Inversion Recovery Snapshot Fast Low Angle Shot (IRSF) sequence with continuous data sampling and retrospective data selection was proposed . However, externally recorded ECG data was still required for cardiac synchronization.…”

Assessment of segmental myocardial blood flow and myocardial perfusion reserve by adenosine‐stress myocardial arterial spin labeling perfusion imaging

“…ASL is most commonly used in the brain for the clinical quantification of cerebral blood flow in cerebrovascular disease and neuro‐oncology, but much work has been done over the past decade to adapt and develop ASL for use in the quantification of blood flow in other organs, including myocardial blood flow (MBF) in both animal and human models . Myocardial ASL is compatible with pharmacological stress testing and is able to detect clinically relevant increases in MBF with vasodilation, making it a potential diagnostic tool for the detection of ischemic heart disease.…”

“…including myocardial blood flow (MBF) in both animal [8][9][10][11][12][13][14][15][16] and human models. [17][18][19][20] Myocardial ASL is compatible with pharmacological stress testing and is able to detect clinically relevant increases in MBF with vasodilation, 21 making it a potential diagnostic tool for the detection of ischemic heart disease.…”