Quantification of progressive joint space narrowing in osteoarthritis of the hip: Longitudinal analysis of the contralateral hip after total hip arthroplasty

Göker, Berna; Doughan, Aida M.; Schnitzer, Thomas J.; Block, Joel A.

doi:10.1002/1529-0131(200005)43:5<988::aid-anr5>3.0.co;2-x

Cited by 56 publications

(48 citation statements)

References 15 publications

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“…We found a 71% decrease in the risk of change to Charnley Class B for each 1-mm increment (Table 1). This result correlates the findings of some authors who showed associations of joint space width with development of symptoms or the need for hip arthroplasty [2,4,10]. However, the finding of an eccentric joint space showed just as strong an association with the change to Charnley Class B as the minimum joint space width in a preliminary bivariate analysis (HR, 12; p = 0.001).…”

Section: Discussionsupporting

confidence: 89%

“…This could be because a substantial number of hips in our cohort were included because they showed no symptoms at baseline evaluation but already had indicators that the osteoarthritic process was engaged. Similarly, Goker et al [10] noted a 21% rate of hip arthroplasty performed during the course of their study. These survivorship results also are consistent with the findings of Vossinakis et al [20], who reported an increased risk of development of contralateral OA in patients with idiopathic OA in one hip, and the results of Clohisy et al [3], who found a high prevalence of structural abnormalities consistent with femoroacetabular impingement in patients with idiopathic OA and a high rate of subsequent contralateral THA.…”

Section: Discussionmentioning

confidence: 72%

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The Natural History of Osteoarthritis: What Happens to the Other Hip?

Amstutz

Duff

2016

Clinical Orthopaedics &Amp; Related Research

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Background Idiopathic osteoarthritis (OA) is a common diagnosis leading to hip arthroplasty. Patients undergoing unilateral hip arthroplasty often wonder whether their other hip will follow the same path as the one that was operated on, and if so, when? There also are limited data available to predict from AP radiographs which contralateral hips will have OA develop and which will not. Questions/purposes We sought (1) to determine the incidence of contralateral osteoarthritic degeneration in a group of patients who were treated with unilateral hip arthroplasty; and (2) to identify clinical and radiographic features associated with the development of contralateral OA. Methods Between 1998 and 2010, we performed 398 hip arthroplasties on patients with unilateral primary hip OA, who at the time of surgery did not have any symptoms in the contralateral hip. Of those, 367 (92%) had a minimum 2-year radiographic followup (mean, 11 years; range, 2-17 years). The 31 patients dropped from the study for lack of radiographic followup had comparable preoperative features as the study group. We performed a radiographic analysis on the baseline AP radiographs to see what factors were associated with arthritis progression, and we performed Kaplan-Meier survivorship analysis with contralateral hip pain and contralateral THA as the endpoints. Results Kaplan-Meier survival estimates indicated that 10 years after the baseline evaluation, 59% (95% CI, 53%-65%) of the patients remained free of symptoms on the contralateral hip and 81% (95% CI, 75%-85%) remained free of an arthroplasty on the contralateral hip. Sex, age, weight, or BMI were not associated with the development of OA on the contralateral hip with the numbers available. Reduced minimum joint space width (hazard ratio, 0.299; 95% CI, 0.237-0.378), low center-edge angle (hazard ratio, 0.941; 95% CI, 0.915-0.968), low head-to-neck ratio (hazard ratio, 1.555; 95% CI, 1.088-2.223), and the presence of osteophytes (hazard ratio, 1.453; 95% CI, 1.001-2.110) were associated with the development of contralateral OA. In hips with a center-edge angle greater than 25°, a head-to-neck ratio of 1.3 or less increased the chances of development of OA by 86% (hazard ratio,

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Section: Discussionsupporting

confidence: 89%

Section: Discussionmentioning

confidence: 72%

The Natural History of Osteoarthritis: What Happens to the Other Hip?

Amstutz

Duff

2016

Clinical Orthopaedics &Amp; Related Research

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“…Both, intrarater and interrater reliability has been significantly higher for joint space measurement than for Kellgren and Lawrence scoring (10,27), and the findings that decline of JSW in OA proceeds in a linear manner (28) and that JSW is predictive of long-term progression of joint-space narrowing (29) make measurement of JSW suitable for clinical trials and prioritize the identification of genes responsible for cartilage formation and homeostasis.…”

Section: Discussionmentioning

confidence: 99%

Genome-wide association and functional studies identify theDOT1Lgene to be involved in cartilage thickness and hip osteoarthritis

Betancourt

Cailotto

Kerkhof

et al. 2012

Proc. Natl. Acad. Sci. U.S.A.

161

124

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Hip osteoarthritis (HOA) is one of the most disabling and common joint disorders with a large genetic component that is, however, still ill-defined. To date, genome-wide association studies (GWAS) in osteoarthritis (OA) and specifically in HOA have yielded only few loci, which is partly explained by heterogeneity in the OA definition. Therefore, we here focused on radiographically measured joint-space width (JSW), a proxy for cartilage thickness and an important underlying intermediate trait for HOA. In a GWAS of 6,523 individuals on hip-JSW, we identified the G allele of rs12982744 on chromosome 19p13.3 to be associated with a 5% larger JSW ( P = 4.8 × 10 −10 ). The association was replicated in 4,442 individuals from three United Kingdom cohorts with an overall meta-analysis P value of 1.1 × 10 −11 . The SNP was also strongly associated with a 12% reduced risk for HOA ( P = 1 × 10 −4 ). The SNP is located in the DOT1L gene, which is an evolutionarily conserved histone methyltransferase, recently identified as a potentially dedicated enzyme for Wnt target-gene activation in leukemia. Immunohistochemical staining of the DOT1L protein in mouse limbs supports a role for DOT1L in chondrogenic differentiation and adult articular cartilage. DOT1L is also expressed in OA articular chondrocytes. Silencing of Dot1l inhibited chondrogenesis in vitro. Dot1l knockdown reduces proteoglycan and collagen content, and mineralization during chondrogenesis. In the ATDC5 chondrogenesis model system, DOT1L interacts with TCF and Wnt signaling. These data are a further step to better understand the role of Wnt-signaling during chondrogenesis and cartilage homeostasis. DOT1L may represent a therapeutic target for OA.

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“…In one study evaluating the probability of contralateral THAs in 99 patients with a mean followup of 104 months (range, 12-149 months), after excluding patients undergoing contralateral THA within 12 months of index THA, the risk of contralateral THA was reportedly 21% [10].…”

Section: Discussionmentioning

confidence: 99%

“…In patients with bilateral disease, the chance of subsequent contralateral THA after unilateral THA is anywhere from 16% to 85% [10,12,[19][20][21][22]. Factors related to subsequent joint arthroplasty in the contralateral joint are described as the radiographic grade of the joint [10,21] and patient age [17,21] at index arthroplasty. Although there is a study regarding the degree of radiographic OA and patient age [21], it does not evaluate symptoms in the contralateral hip and correlate this with radiographic grading in the contralateral hip at index THA.…”

Section: Introductionmentioning

confidence: 99%

Incidence of Contralateral THA After Index THA for Osteoarthritis

Sayeed

Johnson

Mont

2012

Clinical Orthopaedics &Amp; Related Research

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Background Currently more than 200,000 THAs are performed annually in the United States. In patients with bilateral disease, the chance of subsequent contralateral THA reportedly ranges from 16% to 85%. Factors influencing contralateral THA are not completely understood. Questions/Purposes We therefore determined (1) the 10-year probability free of progression to contralateral THA after index THA, (2) whether demographics differed between those who did and did not ultimately undergo contralateral THA, and (3) whether initial clinical symptoms and/or degree of radiographic osteoarthritis affects progression. Patients and Methods We retrospectively identified 332 patients with minimum 24-month followup and primary osteoarthritis who underwent unilateral THA between 2001 and 2008. There were 150 men and 182 women with a mean age of 61 years (range, 27-93 years) and a mean BMI of 29.6 kg/m 2 (range, 17.6-49.2 kg/m 2 ). We reviewed clinical, radiographic, and demographic data at index THA and last followup and classified patients as low, indeterminate, or high risk of undergoing contralateral THA.Results Seventy-four of the 332 patients (22%) underwent contralateral THA, resulting in an 83% 10-year probability free of progression to the contralateral hip. Low-risk patients had a less than 1% chance of progression, indeterminate-risk patients had a 16% to 24% chance of progression, and high-risk patients had a 97% chance of progression.

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Quantification of progressive joint space narrowing in osteoarthritis of the hip: Longitudinal analysis of the contralateral hip after total hip arthroplasty

Cited by 56 publications

References 15 publications

The Natural History of Osteoarthritis: What Happens to the Other Hip?

The Natural History of Osteoarthritis: What Happens to the Other Hip?

Genome-wide association and functional studies identify theDOT1Lgene to be involved in cartilage thickness and hip osteoarthritis

Incidence of Contralateral THA After Index THA for Osteoarthritis

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