Quantification of right ventricular extracellular volume in pulmonary hypertension using cardiac magnetic resonance imaging

Habert, Paul; Capron, Thibaut; Hubert, Sandrine; Bentatou, Zakarya; Bartoli, Axel; Tradi, Farouk; Renard, Sébastien; Rapacchi, Stanislas; Guye, Maxime; Bernard, Monique; Habib, Gilbert; Jacquier, Alexis

doi:10.1016/j.diii.2019.12.008

Cited by 14 publications

(5 citation statements)

References 45 publications

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“…Strain is a possible biomarker to detect early or subclinical alterations in LV function. It is used as a surrogate for treatment outcomes because it reflects myocardial deformation more accurately than LVEF [22][23] . CMS patients have not been diagnosed using the CMR-FT method, but PAH patients have been diagnosed.…”

Section: Discussionmentioning

confidence: 99%

Assessment of biventricular function in Patients with chronic mountain sickness by cardiac magnetic resonance T1 mapping and feature tracking technique

Meng,

Wang,

Bao

et al. 2024

Preprint

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Objective Chronic mountain sickness (CMS) is also known as high-altitude maladaptation syndrome[1]. When the more severe stages of this disease, high-altitude pulmonary hypertension and right ventricular enlargement are commonly found. The cardiac magnetic resonance feature tracking (CMR-FT) and T1mapping can analyze quantitatively bi-ventricular strain in CMS patients and facilitate myocardium impairment early in CMS . Materials and methods 38 individuals including 20 healthy controls and 18 CMS patients who underwent cardiac magnetic resonance (CMR) with Steady-State Free Precession (SSFP) sequences and T1mapping.Biventricular myocardial function measures and strain variables were acquired after post-processing with the CVI42 tool. Based on T1 and ECV maps acquired using a modified Look Locker inversion recovery approach, the pre/post-enhancemant T1 and ECV values of the biventricles were determined. The parameters linked to the total biventricular systolic strain were assessed using conventional cine images and tissue tracking analytic techniques. Results (1) CMR-FT results: Global circumferential strain(GCS), Global radial strain(GRS), and Global longitudinal strain(GLS) were significantly lower in both ventricular in CMS patients than in healthy controls (all p < 0.05). GRS and GCS showed moderate correlation in the left and right ventricles in the CMS group (r = 0.671, p = 0.002; r = 0.597, p = 0.009, respectively) .This shows that their onset time may be earlier than the decline time of left ventricular ejection fraction(LVEF)and right ventricular ejection fraction(RVEF). (2) T1 mapping results: For the right ventricle, pre/post enhancement T1 values and ECV were higher in CMS patients than in controls whole native T1 values were 1374.3 ± 157.6ms, vs 1164.6 ± 60.1ms;whole post T1 values were 551.7 ± 42.2ms vs 485.1 ± 17.2ms and ECV values were 34.2 ± 6.8% vs 25.2 ± 3.6%; the differences were significant (p < 0.05). The results show that their onset time may be earlier than the decline time of left ventricular ejection fraction(LVEF)and right ventricular ejection fraction(RVEF), indicating that myocardium is impaired in CMS. Conclusions For the quantitative evaluation of biventricular strain parameters and ventricular myocardial fibrosis in patients with CMS, CMR-FT and mapping procedures are practicable and repeatable. They may also efficiently identify early biventricular damage in individuals with CMS.

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Section: Discussionmentioning

confidence: 99%

Assessment of biventricular function in Patients with chronic mountain sickness by cardiac magnetic resonance T1 mapping and feature tracking technique

Meng,

Wang,

Bao

et al. 2024

Preprint

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“…T1 mapping is a commercially available fast imaging technique initially used to detect myocardial fibrosis (25–27). T1 relaxation times reflect the status of the extracellular matrix, including extracellular collagen that may be an indicator of fibrosis (25–27). Equivalently to myocardial fibrosis, the growth of the extracellular matrix, along with extracellular collagen in CP, causes fibrosis of the pancreatic parenchyma (28).…”

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Quantification of parenchymal fibrosis in chronic pancreatitis: relation to atrophy and pancreatic function

et al. 2022

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Background Non-invasive modalities for assessing chronic pancreatitis (CP) are needed in clinical practice. Purpose To investigate the correlation between magnetic resonance elastography (MRE)-derived stiffness and T1 relaxation times (as proxies of fibrosis) and explore their relationships to gland volume and pancreatic functions in patients with CP and healthy controls (HCs). Material and Methods In 49 patients with CP and 35 HCs, pancreatic stiffness, T1 relaxation times, and gland volume were assessed. Fecal elastase and the presence of diabetes were used to evaluate pancreatic exocrine and endocrine functions. Uni- and multivariable linear regression models were used to analyze correlations between imaging parameters. Results There was a positive correlation between MRE-derived stiffness and T1 relaxation times in patients with CP (R2 = 0.42; P < 0.001) and HCs (R2 = 0.14; P = 0.028). There was no correlation between MRE-derived stiffness and gland volume in patients (R2 = 0.007; P = 0.065) or HCs (R2 = 0.010; P = 0.57). T1 relaxation time was correlated to gland volume (R2 = 0.19; P = 0.002) in patients with CP but not in the HCs ( P = 0.056). Severity of pancreatic functional impairment was reflected by increased fibrosis-related parameters in patients without functional impairment, followed by a further increase in fibrosis-related parameters and reduction in gland volume in patients with pancreatic functional impairments. Conclusion Pancreatic MRE-derived stiffness and T1 relaxation times might reflect early pathophysiological changes in CP. The dynamic correlation with pancreatic function suggests that these parameters may be useful for the non-invasive and early identification of CP.

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“… 221–223 Extracellular volume measured by cardiovascular magnetic resonance correlates with known echocardiographic prognostic markers of right ventricular systolic function. 224 225 Despite substantial progress in this field, more research is needed into the biology and pathophysiology of the right ventricle. 226 …”

Section: Hallmarks Of Pathophysiology Of Pulmonary Arterial Hypertensionmentioning

confidence: 99%

Pathophysiology and new advances in pulmonary hypertension

Bousseau

Fais

et al. 2023

bmjmed

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Pulmonary hypertension is a progressive and often fatal cardiopulmonary condition characterised by increased pulmonary arterial pressure, structural changes in the pulmonary circulation, and the formation of vaso-occlusive lesions. These changes lead to increased right ventricular afterload, which often progresses to maladaptive right ventricular remodelling and eventually death. Pulmonary arterial hypertension represents one of the most severe and best studied types of pulmonary hypertension and is consistently targeted by drug treatments. The underlying molecular pathogenesis of pulmonary hypertension is a complex and multifactorial process, but can be characterised by several hallmarks: inflammation, impaired angiogenesis, metabolic alterations, genetic or epigenetic abnormalities, influence of sex and sex hormones, and abnormalities in the right ventricle. Current treatments for pulmonary arterial hypertension and some other types of pulmonary hypertension target pathways involved in the control of pulmonary vascular tone and proliferation; however, these treatments have limited efficacy on patient outcomes. This review describes key features of pulmonary hypertension, discusses current and emerging therapeutic interventions, and points to future directions for research and patient care. Because most progress in the specialty has been made in pulmonary arterial hypertension, this review focuses on this type of pulmonary hypertension. The review highlights key pathophysiological concepts and emerging therapeutic directions, targeting inflammation, cellular metabolism, genetics and epigenetics, sex hormone signalling, bone morphogenetic protein signalling, and inhibition of tyrosine kinase receptors.

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Quantification of right ventricular extracellular volume in pulmonary hypertension using cardiac magnetic resonance imaging

Cited by 14 publications

References 45 publications

Assessment of biventricular function in Patients with chronic mountain sickness by cardiac magnetic resonance T1 mapping and feature tracking technique

Assessment of biventricular function in Patients with chronic mountain sickness by cardiac magnetic resonance T1 mapping and feature tracking technique

Quantification of parenchymal fibrosis in chronic pancreatitis: relation to atrophy and pancreatic function

Pathophysiology and new advances in pulmonary hypertension

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