Quantification of rutin in rat’s brain by UHPLC/ESI-Q-TOF-MS/MS after intranasal administration of rutin loaded chitosan nanoparticles

Ahmad, Niyaz; Naqvi, Atta Abbas; Alam, Aftab; Samim, Mohd; Iqbal, Zeenat; Ahmad, Farhan Jalees

doi:10.17179/excli2016-361

Cited by 13 publications

(7 citation statements)

References 24 publications

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“…The phenolic acid and flavonoid libraries of Ruta graveolens, Carpobrotus edulis ([ 27 , 28 ]: rutin 1), Hibiscus sabdariffa ( ; RND DB 2.0 Phenolic Acids: rutin 2, last modified 30 September 2022), Zizyphus jujuba var. inermis (Bunge) Rehder ([ 29 , 30 , 31 ]: rutin 3) were constructed using data from the literature. Phenolic acid and flavonoid derivatives were identified from the data of these libraries, comprising compound names, used parts, molecular weights, and MS fragment ion patterns.…”

Section: Methodsmentioning

confidence: 99%

Oenanthe javanica Ethanolic Extract Alleviates Inflammation and Modifies Gut Microbiota in Mice with DSS-Induced Colitis

et al. 2022

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Oenanthe javanica, commonly known as water dropwort, has long been used to treat acute and chronic hepatitis, abdominal pain, alcohol hangovers, and inflammation in various traditional medicine systems in Asia. However, whether O. javanica has beneficial effects on colitis-induced intestinal damage remains elusive. This study tested the hypothesis that O. javanica has anti-inflammatory and antioxidant activities in mice with dextran sulfate sodium (DSS)-induced colitis. First, treatment of O. javanica ethanol extract (OJE) inhibited the production of inflammatory cytokines in lipopolysaccharide-affected macrophages. Second, in mice with DSS-induced colitis, OJE administration reduced pathological damage to the colon while alleviating weight gain and decreasing colon length, including inflammation and mucosal necrosis. In addition, OJE significantly (p < 0.01) restricted the activation of nuclear factor-κB (NF-κB) and the secretion of pro-inflammatory mediators and increased the expression of Nrf2-phase 2 antioxidant enzymes. The results of 16S rRNA gene sequencing workflows for taxonomic assignment analysis confirmed that the diversity (richness and evenness) of fecal microbiota was markedly elevated in the OJE group. OJE administration reduced the abundance of Proteobacteria including Escherichia and increased the abundance of the genus Muribaculum. These results suggested that OJE exerts beneficial effects on inflammation and gut microbial composition in a mouse model of colitis.

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Section: Methodsmentioning

confidence: 99%

Oenanthe javanica Ethanolic Extract Alleviates Inflammation and Modifies Gut Microbiota in Mice with DSS-Induced Colitis

et al. 2022

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“…For example, compared with free Rutin, Rutin-loaded mucoadhesive polymeric nanoparticles administrated via nasal delivery significantly markedly increased the Rutin concentration in the brain and had better protective effects on cerebral ischemia ( Ahmad et al, 2016a ). Ahmad and Collenges also designed Rutin-loaded chitosan NPs, which effectively improved drug delivery into the brain after intranasal administration ( Ahmad et al, 2016b ). In conclusion, Rutin-loaded NPs are promising in guarding neurons against cell death and oxidative stress during chemotherapy.…”

Section: Natural Products For the Treatment Of Crcimentioning

confidence: 99%

Natural products for the treatment of chemotherapy-related cognitive impairment and prospects of nose-to-brain drug delivery

He,

Zhou,

Jiang

et al. 2024

Front. Pharmacol.

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Chemotherapy-related cognitive deficits (CRCI) as one of the common adverse drug reactions during chemotherapy that manifest as memory, attention, and executive function impairments. However, there are still no effective pharmacological therapies for the treatment of CRCI. Natural compounds have always inspired drug development and numerous natural products have shown potential therapeutic effects on CRCI. Nevertheless, improving the brain targeting of natural compounds in the treatment of CRCI is still a problem to be overcome at present and in the future. Accumulated evidence shows that nose-to-brain drug delivery may be an excellent carrier for natural compounds. Therefore, we reviewed natural products with potential anti-CRCI, focusing on the signaling pathway of these drugs’ anti-CRCI effects, as well as the possibility and prospect of treating CRCI with natural compounds based on nose-to-brain drug delivery in the future. In conclusion, this review provides new insights to further explore natural products in the treatment of CRCI.

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“…The optimal extraction method utilized a mixture of ethyl acetate and acetonitrile, achieving excellent recovery and a linear dynamic range for rutin concentration determination in the brain. This method ensures that RT-CS-NPs efficiently deliver rutin to the brain, demonstrating their potential for enhancing drug delivery via the intranasal route [ 129 ].…”

Section: Specific Treatment and Conditionsmentioning

confidence: 99%

“…The initial phase of testing should focus on the detailed characterization of nanoparticles. This includes determining particle size, surface charge, and morphology, critical for understanding the basic properties that affect behavior in biological systems [ 24 , 25 , 27 , 41 , 42 , 43 , 44 , 111 , 115 , 116 , 119 , 122 , 123 , 125 , 129 ]. Advanced microscopy and spectroscopy techniques such as Scanning Electron Microscopy (SEM), Dynamic Light Scattering (DLS), and Fourier Transform Infrared Spectroscopy (FTIR) should also be employed to provide deeper insights into the physical and chemical properties of the nanoparticles [ 8 , 20 , 25 , 28 , 44 , 109 ].…”

Section: Testingmentioning

confidence: 99%

Chitosan Nanoparticles for Intranasal Drug Delivery

Omidian,

Gill,

Dey Chowdhury

et al. 2024

Pharmaceutics

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This manuscript explores the use of nanostructured chitosan for intranasal drug delivery, targeting improved therapeutic outcomes in neurodegenerative diseases, psychiatric care, pain management, vaccination, and diabetes treatment. Chitosan nanoparticles are shown to enhance brain delivery, improve bioavailability, and minimize systemic side effects by facilitating drug transport across the blood–brain barrier. Despite substantial advancements in targeted delivery and vaccine efficacy, challenges remain in scalability, regulatory approval, and transitioning from preclinical studies to clinical applications. The future of chitosan-based nanomedicines hinges on advancing clinical trials, fostering interdisciplinary collaboration, and innovating in nanoparticle design to overcome these hurdles and realize their therapeutic potential.

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Quantification of rutin in rat’s brain by UHPLC/ESI-Q-TOF-MS/MS after intranasal administration of rutin loaded chitosan nanoparticles

Cited by 13 publications

References 24 publications

Oenanthe javanica Ethanolic Extract Alleviates Inflammation and Modifies Gut Microbiota in Mice with DSS-Induced Colitis

Oenanthe javanica Ethanolic Extract Alleviates Inflammation and Modifies Gut Microbiota in Mice with DSS-Induced Colitis

Natural products for the treatment of chemotherapy-related cognitive impairment and prospects of nose-to-brain drug delivery

Chitosan Nanoparticles for Intranasal Drug Delivery

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