Quantification of selected fat soluble vitamins and carotenoids in infant formula and dietary supplements using fast liquid chromatography coupled with tandem mass spectrometry

Nimalaratne, Chamila; Sun, Chenxing; Wu, Jianping; Curtis, Jonathan M.; Schieber, Andreas

doi:10.1016/j.foodres.2014.08.034

Cited by 37 publications

(17 citation statements)

References 29 publications

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“…They are classified as water‐soluble and fat‐soluble. The vitamin B complex and vitamin C being part of the first group . Fruits can have significant amounts of vitamins and supply part of the daily recommended intake (DRI) for the population.…”

Section: Introductionmentioning

confidence: 99%

“…In addition, vitamins, anthocyanins and carotenoids have antioxidant properties and the consumption of fruits and vegetables have been indicated because of their possible effects in the prevention of chronic diseases, besides their role in helping in the homeostasis of the organism. 16,17 However, the content of bioactive compounds and vitamins is influenced by climatic factors, crop type, variety, environmental conditions, location, maturity and agronomical practices such as irrigation and germination. 18 Based on this context, the aim of this research was the determination of vitamin composition, bioactive compounds and antioxidant capacity of seven fruits belonging to the Myrtaceae family from different regions in south Brazil.…”

Section: Introductionmentioning

confidence: 99%

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Vitamin and bioactive compound diversity of seven fruit species from south Brazil

et al. 2019

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BACKGROUND The consumption of native tropical fruits represents an important source of bioactive food and vitamins for consumers. The aim of this study was to determine the composition of vitamins, bioactive compounds and the antioxidant activity of seven native fruits of the Myrtaceae family from south Brazil. RESULTS Sample 1 of Eugenia pyriformis presented the highest value of β‐carotene (0.1021 g kg−1), lutein (0.0511 g kg−1), zeaxanthin (0.0370 g kg−1), and α‐carotene (0.0112 g kg−1), of all analyzed samples. The three samples of Eugenia uniflora L presented the highest lycopene (0.1876, 0.1240 and 0.1615 g kg−1) and vitamin A content (0.106, 0.035 and 0.178 g kg−1 RAE) of all seven species analyzed. The cyanidin 3‐glucoside was the most common anthocyanin found in fruits in the present study. Two samples of Plinia peruviana presented higher antioxidant capacity by the ABTS radical method (0.80 and 0.67 mol TEs kg−1) among the fruits analyzed. The samples of Campomanesia xanthocarpa analyzed stood out owing to the high content of vitamin C present (23.89, 36.83 and 35.05 g kg−1). The values of pantothenic acid in Plinia peruviana account for 20% of daily requirements. CONCLUSION In conclusion, the native fruits studied can provide an appreciable amount of vitamins and bioactive compounds. © 2018 Society of Chemical Industry

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Vitamin and bioactive compound diversity of seven fruit species from south Brazil

et al. 2019

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“…[2,10] Recently, a liquid chromatographytandem mass spectrometry (LC-MS/MS)-based bioanalysis method has been developed. [3,8] Almost those papers only gave analysis method and did not study about validation data.…”

Section: Introductionmentioning

confidence: 99%

Quantification of lutein from Marigold flower (Tagetes erecta L.) petals by liquid chromatography – tandem mass spectrometry method

Nguyệt

Hà²,

Bình

et al. 2019

Vietnam Journal of Chemistry

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An attempt was made to develop a liquid chromatography-tandem mass spectrometric (LC-MS/MS) method which is rapid, sensitive and validated for the qualitative and quantitative analysis of lutein from the Marigold petals. Linearity, specificity, sensitivity, precision, accuracy, and analyte stability were evaluated. Two multiple reaction-monitoring (MRM) transitions for each analyte were observed: 568.01 > 104.53 and 568.01 > 118.60 for lutein. The retention time of the substance was 3.22 minutes. In this study, an excellent linearity was obtained with correlation coefficient, R, higher than 0.999. The limit of detection (LOD) and limit of quantification (LOQ) were 0.0078 and 0.0240 ng/mL, respectively. This paper is one of the few studies on these subjects and represents the first application of advanced LC-MS/MS technology.

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“…Currently, chromatographic separation of T and T3 is achievable with the application of normal‐phase (Che et al, ; Grigoriadou, Androulaki, Psomiadou, & Tsimidou, ; Nagy, Courtet‐Compondu, Holst, & Kussmann, ) and reversed‐phase (Bartosińska, Jacyna, et al, ; Delgado‐Zamarreño, Bustamante‐Rangel, Sierra‐Manzano, Verdugo‐Jara, & Carabias‐Martínez, ; Grebenstein & Frank, ; Nimalaratne, Sun, Wu, Curtis, & Schieber, ; Tsochatzis & Tzimou‐Tsitouridou, ; Veres et al, ; Viñas, Bravo‐Bravo, López‐García, Pastor‐Belda, & Hernández‐Córdoba, ) high‐performance liquid chromatography. However, total separation of all eight target compounds on commonly applied reversed‐phase columns, like C 18 , is unachievable (Delgado‐Zamarreño et al, ; Tsochatzis & Tzimou‐Tsitouridou, ; Veres et al, ) or remains a challenge on such stationary phases like C 30 for long elution times (Nimalaratne et al, ). Recent development of new stationary phases containing pentafluorophenyl (Grebenstein & Frank, ; Viñas et al, ) or naphthylethyl groups (Bartosińska, Jacyna, et al, ) enabled successful separation of all eight ( α ‐, β ‐, γ ‐ and δ ‐tocopherol and four corresponding tocotrienols) isomers of tocochromanols.…”

Section: Introductionmentioning

confidence: 99%

Determination of tocopherols and tocotrienols in human breast adipose tissue with the use of high performance liquid chromatography–fluorescence detection

Bartosińska

Jacyna

Moor

et al. 2018

Biomedical Chromatography

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Tocopherols and tocotrienols have been extensively studied owing to their anticancer potential, especially against breast cancer. Therefore, the aim of this study was to quantitatively determine tocochromanols in human breast adipose tissue with the use of HPLC-FLD. The sample preparation procedure included homogenization and solvent extraction with isopropanol-ethanol-0.1% formic acid mixture prior to solid-phase extraction. After implementation of central composite design, satisfactory separation of all eight target compounds was achieved within 10.5 min. Chromatographic runs were carried out with the use of a naphthylethyl chromatographic column with methanol-water mixture (89:11, v/v) as the mobile phase. Fluorescence detection of tocochromanols was performed with excitation and emission wavelengths 298 and 330 nm, respectively. The method was validated in terms of linearity, carryover, recovery, precision, accuracy and stability. Extraction yield was also determined for accurate evaluation of vitamin E content in human breast adipose tissue samples. Finally, concentrations of particular tocochromanols compounds were assessed in human breast adipose tissue samples obtained from 99 patients, including women with breast cancer, healthy volunteers and deceased women who had died as a result of accidents. The raw data was transformed according to the newly developed equation for accurate estimation of the concentrations of tocochromanols in breast adipose tissue samples. Results obtained in the study indicated that the proposed analytical assay could be useful in breast cancer research.

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Quantification of selected fat soluble vitamins and carotenoids in infant formula and dietary supplements using fast liquid chromatography coupled with tandem mass spectrometry

Cited by 37 publications

References 29 publications

Vitamin and bioactive compound diversity of seven fruit species from south Brazil

Vitamin and bioactive compound diversity of seven fruit species from south Brazil

Quantification of lutein from Marigold flower (Tagetes erecta L.) petals by liquid chromatography – tandem mass spectrometry method

Determination of tocopherols and tocotrienols in human breast adipose tissue with the use of high performance liquid chromatography–fluorescence detection

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