Quantification of single solute and competitive adsorption isotherms using a closed-loop perturbation method

Blümel, Clemens; Hugo, P.; Seidel‐Morgenstern, A.

doi:10.1016/s0021-9673(99)00920-6

Cited by 68 publications

(39 citation statements)

References 18 publications

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“…Static methods such as gravimetry (Thompson and Fuller 1987), volumetry, and infrared absorption (SoussenJacob et al 1989) or dynamic methods such as frontal analysis (FA) (Lisec et al 2001), perturbation method (PM) (Blumel et al 1999), elution by characteristic points (ECP), and inverse method (IM) (Felinger et al 2003) have been used for isotherm determination. Static methods are typically slow and mostly used for gas adsorption (Rajendran and Chen 2009), whereas dynamic methods which involve the flow of a fluid through a column packed with stationary phase, are well suited for liquid chromatography.…”

Section: Subscripts and Superscriptsmentioning

confidence: 99%

Nonlinear direct inverse method: a shortcut method for simultaneous calibration and isotherm determination

2013

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This work addresses a way to combine isotherm determination and nonlinear calibration. In this method, like the classical inverse method, experimental elution profiles are compared with the results of a detailed model that accounts for nonlinearity in equilibrium, axial dispersion, and mass transfer kinetics. However, unlike the classical inverse method, the calibration of detector is carried out simultaneously with isotherm determination thereby reducing cost and saving time. In this study no limitation is imposed on the linearity of the detector signal or on the overlapping of elution profiles for the separation of enantiomers. The method has been experimentally validated for the separation of a mixture of guaifenesin enantiomers over a wide range of concentration.

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Section: Subscripts and Superscriptsmentioning

confidence: 99%

Nonlinear direct inverse method: a shortcut method for simultaneous calibration and isotherm determination

2013

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“…A perturbation method, described by Blümel et al, was applied to determine the adsorption isotherms [59]. Fig.…”

Section: System and Model Parametersmentioning

confidence: 99%

Preparative Gradient Chromatography

Seidel‐Morgenstern

2005

Chem Eng & Technol

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During a chromatographic separation, it is convenient to keep the essential operating parameters like temperature, pressure, mobile phase flow-rate, and mobile phase composition constant. Though, it is well known that in contrast to this isocratic operation the intelligent modulation of certain operating parameters can improve the separation performance significantly. Such gradient approaches are widely applied in analytical (linear) chromatography to reduce the time of analysis and to enhance the selectivity. In contrast, the extent of application of these gradients is still rather limited in the field of preparative (nonlinear) chromatography. The first part of this paper is devoted to the discussion of the principal differences between linear and nonlinear and isocratic and gradient chromatography. The second part focuses on introducing a countercurrent process that allows separation in a continuous manner, efficiently exploiting a two-step solvent composition gradient.

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“…When such a wave reaches the column outlet, a negative or a positive peak is registered by the detector, depending on whether the concentrations of the sample compounds injected are higher or lower than their equilibrium concentrations at the start of the experiment. The well-known Langmuir theoretical approach relates the total concentration of solute in the stationary phase (C s ) and that in the mobile phase (C m ) by the following equation [13,14]:…”

Section: Langmuir Approachmentioning

confidence: 99%

“…The solute retention factor k was directly proportional to the slope of its adsorption isotherm and can be thus given by the following equation [13,14]:…”

Section: Langmuir Approachmentioning

confidence: 99%

Saccharose effects on surface association of phenol derivatives with porous graphitic carbon

André

Guillaume

2004

Journal of Chromatography A

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Quantification of single solute and competitive adsorption isotherms using a closed-loop perturbation method

Cited by 68 publications

References 18 publications

Nonlinear direct inverse method: a shortcut method for simultaneous calibration and isotherm determination

Nonlinear direct inverse method: a shortcut method for simultaneous calibration and isotherm determination

Preparative Gradient Chromatography

Saccharose effects on surface association of phenol derivatives with porous graphitic carbon

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