Quantification of skin erythema response to topical alcohol in alcohol‐intolerant East Asians

Aoki, Yoshikazu; Wehage, Scott L.; Talalay, Paul

doi:10.1111/srt.12376

Cited by 6 publications

(5 citation statements)

References 20 publications

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“…Ethanol (ethyl alcohol) is initially metabolized by alcohol dehydrogenase (ADH) to acetaldehyde, before further metabolism to acetate by aldehyde dehydrogenase (ALDH). Genetic polymorphism of ADH and ALDH affects enzymatic activity and leads to the accumulation of acetaldehyde, giving rise to the unpleasant systemic symptoms and flushing 6,7 . ADH1B*2 allele is common in East Asia, with rapid ethanol oxidative metabolism leading to the accumulation of acetaldehyde.…”

Section: Discussionmentioning

confidence: 99%

Irritant hand dermatitis to alcohol hand sanitisers in healthcare workers: Possible role of alcohol metabolism polymorphisms

Teo,

Lee,

White

et al. 2023

Contact Dermatitis

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Section: Discussionmentioning

confidence: 99%

Irritant hand dermatitis to alcohol hand sanitisers in healthcare workers: Possible role of alcohol metabolism polymorphisms

Teo,

Lee,

White

et al. 2023

Contact Dermatitis

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“…(2) ABHRs impair the skin barrier on people whose hands are exposed to an occlusive environment or under water immersion, such as healthcare workers who wear gloves for extended periods [ 43 ]. (3) They may induce a burning sensation on previously irritated skin [ 44 ]. (4) Alcohol may cause erythema in alcohol-intolerant people [ 44 ].…”

Section: Discussionmentioning

confidence: 99%

“…(3) They may induce a burning sensation on previously irritated skin [ 44 ]. (4) Alcohol may cause erythema in alcohol-intolerant people [ 44 ]. ABHRs, particularly in confined spaces, may lead to DER (disulfiram–ethanol reaction) after disulfiram treatment [ 45 ].…”

Section: Discussionmentioning

confidence: 99%

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A Novel Handrub Tablet Loaded with Pre- and Post-Biotic Solid Lipid Nanoparticles Combining Virucidal Activity and Maintenance of the Skin Barrier and Microbiome

Machado,

Marinheiro,

Benson

et al. 2023

Pharmaceutics

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Objective: This study aimed to develop a holobiont tablet with rapid dispersibility to provide regulation of the microbiota, virucidal activity, and skin barrier protection. Methods: A 23 factorial experiment was planned to define the best formulation for the development of the base tablet, using average weight, hardness, dimensions, swelling rate, and disintegration time as parameters to be analyzed. To produce holobiont tablets, the chosen base formulation was fabricated by direct compression of prebiotics, postbiotics, and excipients. The tablets also incorporated solid lipid nanoparticles containing postbiotics that were obtained by high-pressure homogenization and freeze-drying. The in vitro virucidal activity against alpha-coronavirus particles (CCoV-VR809) was determined in VERO cell culture. In vitro analysis, using monolayer cells and human equivalent skin, was performed by rRTq-PCR to determine the expression of interleukins 1, 6, 8, and 17, aquaporin-3, involucrin, filaggrin, FoxO3, and SIRT-1. Antioxidant activity and collagen-1 synthesis were also performed in fibroblast cells. Metagenomic analysis of the skin microbiome was determined in vivo before and after application of the holobiont tablet, during one week of continuous use, and compared to the use of alcohol gel. Samples were analyzed by sequencing the V3–V4 region of the 16S rRNA gene. Results: A handrub tablet with rapid dispersibility was developed for topical use and rinse off. After being defined as safe, the virucidal activity was found to be equal to or greater than that of 70% alcohol, with a reduction in interleukins and maintenance or improvement of skin barrier gene markers, in addition to the reestablishment of the skin microbiota after use. Conclusions: The holobiont tablets were able to improve the genetic markers related to the skin barrier and also its microbiota, thereby being more favorable for use as a hand sanitizer than 70% alcohol.

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“…Epidemiological studies have established a link between alcohol consumption and an increase in the prevalence of SS ( 35 ). It is believed that the decomposition of ethanol into acetaldehyde induces vasodilation, leading to facial burning and flushing ( 62 , 63 ).…”

Section: Lifestylesmentioning

confidence: 99%

A review of factors influencing sensitive skin: an emphasis on built environment characteristics

Chen,

Wen,

et al. 2023

Front. Public Health

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BackgroundSensitive skin (SS) is a condition characterized by hyperreactivity. Impacting around 37 percent of the worldwide population and exerting an influence on the quality of life for affected individuals. Its prevalence rate has increased due to factors such as elevating stress levels and deteriorating environmental conditions. The exposome factors influencing SS have extended from demographic, biological attributes, and lifestyle to external environments. Built environments (BEs) have demonstrated as root drivers for changes in behaviors and environmental exposure which have the potential to trigger SS, but the review of the associations between BEs and SS is currently lacking.ObjectiveThis review aims to achieve two primary objectives: (1) Examine exposome factors that exert influence on SS at the individual and environmental levels. (2) Develop a theoretical framework that establishes a connection between BEs and SS, thereby offering valuable insights into the impact of the built environment on this condition.MethodsAn extensive literature search was carried out across multiple fields, including sociology, epidemiology, basic medicine, clinical medicine, and environmental research, with a focus on SS. To identify pertinent references, renowned databases such as PubMed, Web of Science, and CNKI were utilized.ResultsSS is the outcome of interactions between individual attributes and environmental factors. These influencing factors can be categorized into five distinct classes: (1) demographic and socioeconomic characteristics including age, gender, and race; (2) physiological and biological attributes such as emotional changes, skin types, sleep disorders, and menstrual cycles in women; (3) behavioral factors, such as spicy diet, cosmetic use, alcohol consumption, and physical exercise; (4) natural environmental features, including climate conditions and air pollution; (5) built environmental features such as population density, green space availability, road network density, and access to public transportation, also have the potential to affect the condition.ConclusionThe importance of interdisciplinary integration lies in its ability to ascertain whether and how BEs are impacting SS. By elucidating the role of BEs in conjunction with other factors in the onset of SS, we can provide guidance for future research endeavors and the formulation of interventions aimed at mitigating the prevalence of SS.

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Quantification of skin erythema response to topical alcohol in alcohol‐intolerant East Asians

Abstract: The ∆a* index is suitable for the quantitative determination of topical alcohol-induced erythema response, and the evaluation of effectiveness of protective strategies against erythema response.

Cited by 6 publications

References 20 publications

Irritant hand dermatitis to alcohol hand sanitisers in healthcare workers: Possible role of alcohol metabolism polymorphisms

Irritant hand dermatitis to alcohol hand sanitisers in healthcare workers: Possible role of alcohol metabolism polymorphisms

A Novel Handrub Tablet Loaded with Pre- and Post-Biotic Solid Lipid Nanoparticles Combining Virucidal Activity and Maintenance of the Skin Barrier and Microbiome

A review of factors influencing sensitive skin: an emphasis on built environment characteristics

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