Quantification of surgical margin shrinkage in the oral cavity

Johnson, Robert E.; Sigman, June D.; Funk, Gerry F.; Robinson, R. A.; Hoffman, Henry T.

doi:10.1002/(sici)1097-0347(199707)19:4<281::aid-hed6>3.3.co;2-4

Cited by 144 publications

(55 citation statements)

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“…In his review article, Batsakis6 maintains the position that measurements of margins on formalin‐fixed specimens are inferior to in situ, frozen section samples because of post‐removal and postfixation shrinkage. Similar results were found by Johnson et al10 when studying oral mucosal margins using canine models. These results are significant, especially if one uses the definition of a clear margin as being >5 mm.…”

Section: Discussionsupporting

confidence: 87%

Surgical margin determination in head and neck oncology: Current clinical practice. The results of an International American Head and Neck Society Member Survey

2005

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No uniform criteria to define a clear surgical margin exist among practicing head and neck surgeons. Most head and neck surgeons consider margins clear if resection completed after an initial positive frozen section margin reveals negative margins, but this view is not shared by all. Most surgeons take frozen sections from the surgical bed; however, error may occur when identifying the positive margin within the surgical bed. The definition of a clear tumor margin after chemoradiation is unclear. These questions could be addressed in a multicenter prospective trial.

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Section: Discussionsupporting

confidence: 87%

Surgical margin determination in head and neck oncology: Current clinical practice. The results of an International American Head and Neck Society Member Survey

2005

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“…Johnson et al. found that canine labiobuccal mucosal margins on histological slides were reduced to half their in vivo size, and tongue mucosal margins on histological slides similarly shrunk by one‐third 23 . Formalin fixation shrinks laryngeal tissues grossly by 9–42% (in the false vocal cord and true vocal cord respectively) relative to freshly excised normal canine larynxes 24 .…”

Section: Discussionmentioning

confidence: 99%

Laryngeal epithelial thickness: a comparison between optical coherence tomography and histology

Kaiser¹,

Rubinstein

Vokes

et al. 2009

Clinical Otolaryngology

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Objectives Optical coherence tomography, an imaging modality using near-infrared light, produces crosssectional tissue images with a lateral pixel resolution of 10 μm. However, normative data is first needed on epithelial thickness for lesion characterisation, and, to date, little exists. The purpose of our study is to measure normal laryngeal epithelial thickness by in vivo optical coherence tomography, and compare these values to those obtained from fixed ex-vivo laryngectomy specimens. Design and Setting Prospective at a single medical center in California, United States. Participants A total of 116 patients undergoing operative endoscopy. Main outcome measures Optical coherence tomography images of clinically normal laryngeal subsites were selected. Calibrated measurements of epithelial thickness at various laryngeal subsites were recorded. Measurements of epithelial thickness from corresponding areas were obtained using optical micrometry on histologically normal regions of 15 total laryngectomy specimens. Descriptive statistics were performed. Results Mean epithelial optical coherence tomography thicknesses were: true vocal cords (81 μm), false vocal cords (78 μm), subglottis (61 μm), aryepiglottic folds (111 μm), laryngeal epiglottis (116 μm) and lingual epiglottis (170 μm). Epithelial thicknesses in fixed tissues were: true vocal cords (103 μm), false vocal cords (79 μm), aryepiglottic folds (205 μm) subglottis (61 μm), laryngeal epiglottis (38 μm) and lingual epiglottis (130 μm). Conclusions Optical coherence tomography does not have the artifacts associated with conventional histologic techniques. The inevitable development of office-based optical coherence tomography devices will increase the precision of laryngeal measurements and contribute to the clinical application of this technology in diagnosing laryngeal disease.

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“…Only 20 margins from 5 cats were measured from the time of surgery through histopathological evaluation. Our sample size is similar to the scope of previous prospective studies evaluating tissue shrinkage in dogs where 6 dogs were used for 36 total measurements for skin shrinkage, 12 specimens were measured for intestinal shrinkage, and 10 dogs were used for 20 total measurements evaluating oral mucosa shrinkage . To minimize errors in gross and histologic margin measurement, a fiducial marker was used as a common reference point at each time point, absolute margin measurements were normalized within individual cases by expressing them as a percentage of their corresponding in vivo GNSM, and a single board CVL personally trimmed all the samples.…”

Section: Discussionmentioning

confidence: 99%

Quantification of surgical margin length changes after excision of feline injection site sarcomas—A pilot study

et al. 2016

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Quantification of surgical margin shrinkage in the oral cavity

Cited by 144 publications

References 0 publications

Surgical margin determination in head and neck oncology: Current clinical practice. The results of an International American Head and Neck Society Member Survey

Surgical margin determination in head and neck oncology: Current clinical practice. The results of an International American Head and Neck Society Member Survey

Laryngeal epithelial thickness: a comparison between optical coherence tomography and histology

Quantification of surgical margin length changes after excision of feline injection site sarcomas—A pilot study

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