Quantification of the visceral and subcutaneous fat by computed tomography: Interobserver correlation of a single slice technique

Sottier, D.; Petit, J.; Guiu, Séverine; Hamza, S.; Benhamiche, H.; Hillon, Patrick; Cercueil, Jean‐Pierre; Krausé, D.; Guiu, Boris

doi:10.1016/j.diii.2013.04.006

Cited by 57 publications

(63 citation statements)

References 19 publications

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“…Previous studies addressed the values of single MRI slice areas to estimate whole-body SM (3,20) and AT (3)(4)(5)(9)(10)(11)(12)(13)(14)(15). Different reference slices were described that resulted in different slice locations for each tissue.…”

Section: Discussionmentioning

confidence: 99%

“…For individual slices obtained at the lumbar spine, several authors showed strong correlations with total-body VAT, SAT, and AT volumes (3)(4)(5)(9)(10)(11)(12)(13)(14)(15). With the comparison of different slices, AT areas 5-10 cm above L4-L5 showed the strongest correlations with total VAT volume, whereas for SAT, the measurement site had no considerable effect on the correlation strength.…”

Section: Introductionmentioning

confidence: 96%

See 1 more Smart Citation

What is the best reference site for a single MRI slice to assess whole-body skeletal muscle and adipose tissue volumes in healthy adults?

Schweitzer

Geisler

Pourhassan

et al. 2015

The American Journal of Clinical Nutrition

243

169

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Background: Whole-body magnetic resonance imaging (MRI) is the gold standard for the assessment of skeletal muscle (SM) and adipose tissue volumes. It is unclear whether single-slice estimates can replace whole-body data. Objective: We evaluated the accuracy of the best single lumbar and midthigh MRI slice to assess whole-body SM, visceral adipose tissue (VAT), and subcutaneous adipose tissue (SAT). Design: Whole-body MRI was performed in 142 healthy adults aged 19-65 y [mean 6 SD age: 37.0 6 11.8 y; BMI (in kg/m 2 ): 25.3 6 5.9]. Single slices were taken at lumbar vertebrae L1-L5 plus intervertebral discs and the thigh (midthigh, 10 cm distally from the midthigh, and 10 cm proximally from the midthigh). The value of single-slice areas was also tested in a longitudinal study on 48 healthy volunteers during weight loss (8.2 6 5.2 kg). Results: Cross-sectionally, all SM and adipose tissue single-slice areas correlated with total tissue volumes (P , 0.01). Because of the close associations between L3 areas and corresponding tissue volumes (r = 0.832-0.986, P , 0.01), this location was identified as the reference to estimate SM and adipose tissue in both sexes. SM, SAT, and VAT areas at L3 explained most of the variance of total tissue volumes (69-97%, with SEs of estimation of 1.96 and 2.03 L for SM, 0.23 and 0.61 L for VAT, and 4.44 and 2.47 L for SAT for men and women, respectively. There was no major effect on the explained variance compared with that for optimal slices. For SM, the optimal slice area was shown at midthigh. With weight-loss changes in total SM, VAT, and SAT, volumes were significantly different from those at baseline (SM changes: 22.8 6 2.9 L; VAT changes: 20.7 6 1.0 L; SAT changes: 25.1 6 6.0 L). The area at L3 reflected changes in total VAT and SAT. To assess changes in total SM volumes, areas at midthigh showed the best evidence. Conclusion: In both sexes, a single MRI scan at the level of L3 is the best compromise site to assess total tissue volumes of SM, VAT, and SAT. By contrast, L3 does not predict changes in tissue components. This trial was registered at clinicaltrials.gov as NCT01737034.Am J Clin Nutr 2015;102:58-65.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 96%

What is the best reference site for a single MRI slice to assess whole-body skeletal muscle and adipose tissue volumes in healthy adults?

Schweitzer

Geisler

Pourhassan

et al. 2015

The American Journal of Clinical Nutrition

243

169

View full text Add to dashboard Cite

show abstract

“…A single slice area is sufficient to measure the abdominal fat [7]. Different levels are described in literature, but VF and subcutaneous fat quantification can be easily measured by single slice CT-scan going through the umbilicus [8]. …”

Section: Introductionmentioning

confidence: 99%

Influence of Visceral Fat in the Outcomes of Colorectal Cancer

et al. 2018

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Aim: To determine the relationship of visceral fat (VF) with the surgical outcome of the patients with colorectal cancer (CRC) submitted to curative surgery. Methods: Retrospective analysis of all patients submitted to CRC surgery during 3 years with a minimum of 5 years of follow-up. We assessed the length of hospital stay, complications, pathologic reports, surgical re-interventions and hospital re-admissions, relapses, survival time and disease-free time. VF was calculated based on patients’ pre-operative CT-scan. The patients were divided into quartiles according to the VF area. Linear regression models and logistic regression models were used to establish a relationship between VF and all data collected. Results: The study included 199 patients (129 with colon cancer [CC] and 70 with rectal cancer). The average area of VF was 115.7 cm². Patients with CRC revealed a direct relationship between VF and postoperative complications (p = 0.043), anastomotic leakage (p = 0.009) and re-operation (p = 0.005). The subgroup of patients with CC had an inverse association between VF and lymph nodes harvested (p = 0.027). Survival analyses did not reveal significant differences. Conclusion: VF has an influence on postoperative complications, anastomotic leakage and re-operation. A negative influence of VF on lymph nodes harvested was observed on CC patients.

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“…Adipose tissue was highlighted by setting threshold values of 2190 to 230 HU, a threshold range used to identify VAT in many similar studies. 20,25,26 VAT was then manually segmented from SAT by using the inner boundary of the abdominal muscle wall as the limit for VAT ( Figure 1). This boundary did not include intermuscular and paravertebral adipose tissue in VAT calculation, as recommended.…”

Section: Methodsmentioning

confidence: 99%

“…CT generates relatively consistent tissue attenuation values which makes adipose tissue (2190 to 230 HU) easy to identify. 25,26 CT is also relatively cheap, widely accessible and fast. The accuracy and reproducibility of measurements in this study further validates the use of CT for VAT quantification in paediatrics.…”

Section: 46-12mentioning

confidence: 99%

Best single-slice location to measure visceral adipose tissue on paediatric CT scans and the relationship between anthropometric measurements, gender and VAT volume in children

O’Connor

Ryan

Foley

2015

BJR

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Objective: Visceral adipose tissue (VAT) is a significant risk factor for obesity-related metabolic diseases. This study investigates (1) the best single CT slice location for predicting total abdominal VAT volume in paediatrics and (2) the relationship between waist circumference (WC), sagittal diameter (SD), gender and VAT volume. Methods: A random sample of 130 paediatric abdomen CT scans, stratified according to age and gender, was collected. Three readers measured VAT area at each intervertebral level between T12 and S1 using ImageJ analysis (National Institute of Health, Bethesda, MD) software by thresholding 2190 to 230 HU and manually segmenting VAT. Single-slice VAT measurements were correlated with total VAT volume to identify the most representative slice. WC and SD were measured at L3-L4 and L4-L5 slices, respectively. Regression analysis was used to evaluate WC, SD and gender as VAT volume predictors. Results: Interviewer and intraviewer reliability were excellent (intraclass correlation coefficient 5 0.99). Although VAT measured at multiple slices correlated strongly with abdominal VAT, only one slice in females at L2-L3 and two slices in males at L1-L2 and L5-S1 were strongly correlated across all age groups. Linear regression analysis showed that WC was strongly correlated with VAT volume (beta 5 0.970, p , 0.001). Conclusion: Single-slice VAT measurements are highly reproducible. Measurements performed at L2-L3 in females and L1-L2 or L5-S1 in males were most representative of VAT. WC is indicative of VAT. Advances in knowledge: VAT should be measured at L2-L3 in female children and at either L1-L2 or L5-S1 in males. WC is a strong indicator of VAT in children. INTRODUCTIONThe prevalence of obesity has increased dramatically over the past 30 years and was recently described by the World Health Organization as a "global epidemic".1 In 1980, 7% of children aged 6-11 years were obese compared with nearly 18% in 2012. Similarly, the percentage of adolescents aged 12-19 years who were obese increased from 5% to almost 21% over the same period.2 The Centers for Disease Control (CDC) and Prevention classifies overweight children as those with a body mass index (BMI) over the 85th percentile and obese children as those with BMI over the 95th percentile relative to a child's age and sex. Currently, more than one-third of children and adolescents are overweight or obese, related to the sex-specific CDC BMI-for-age growth charts from 2000.

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Quantification of the visceral and subcutaneous fat by computed tomography: Interobserver correlation of a single slice technique

Abstract: The interobserver reproducibility of the single slice CT-scan measurement going through the navel (easily detected) is excellent and may therefore be used in oncology as a predictive tool to measure a characteristic of the host and not the tumor.

Cited by 57 publications

References 19 publications

What is the best reference site for a single MRI slice to assess whole-body skeletal muscle and adipose tissue volumes in healthy adults?

What is the best reference site for a single MRI slice to assess whole-body skeletal muscle and adipose tissue volumes in healthy adults?

Influence of Visceral Fat in the Outcomes of Colorectal Cancer

Best single-slice location to measure visceral adipose tissue on paediatric CT scans and the relationship between anthropometric measurements, gender and VAT volume in children

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