Quantification of Thyroid Viscosity in Healthy Subjects Using Ultrasound Shear Wave Dispersion (Viscosity PLUS)

Stoian, Dana; Moisa, Luciana; Amzar, Daniela; Sporea, Ioan; Popa, Alexandru; Bende, Felix; Popescu, Alina; Borlea, Andreea

doi:10.3390/diagnostics12092194

Cited by 4 publications

(5 citation statements)

References 37 publications

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“…Previous studies 20,32 identified a moderate correlation between viscosity and elasticity in the thyroid and kidneys. However, our study provided more conclusive findings.…”

Section: Discussionmentioning

confidence: 91%

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Quantitative Evaluation of the Lumbar Multifidus Muscle by Shear Wave Dispersion in Healthy Adults: A Preliminary Study

Chen,

Li,

Deng

et al. 2024

J of Ultrasound Medicine

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ObjectivesTo investigate the application value of shear wave dispersion (SWD) in healthy adults with the lumbar multifidus muscle (LMM), to determine the range of normal reference values, and to analyze the influences of factors on the parameter.MethodsNinety‐five healthy volunteers participated in the study, from whom 2‐dimensional, shear wave elastography (SWE), and SWD images of the bilateral LMM were acquired in three positions (prone, standing, and anterior flexion). Subcutaneous fat thickness (SFH), SWE velocity, and SWD slope were measured accordingly for analyses.ResultsThe mean SWD slope of the bilateral LMM in the prone position was as follows: left: 14.8 ± 3.1 (m/second)/kHz (female) and 13.0 ± 2.5 (m/second)/kHz (male); right: 14.8 ± 3.7 (m/second)/kHz (female) and 14.2 ± 3.4 (m/second)/kHz (male). In the prone position, there was a weak negative correlation between the bilateral LMM SWD slope of activity level 2 and level 1 (β = −1.5 (2 versus 1, left), −1.9 (2 versus 1, right), all P < .05), and between the left SWD slope of activity level 3 and level 1 (β = −2.3 [3 versus 1, left], P < .05). The correlation between SWE velocity and SWD slope value changed with the position: there was a weak positive correlation in the prone position (r = 0.3 [left], 0.37 [right], both P < .05), and a moderate positive correlation in the standing and anterior flexed positions (r = 0.49–0.74, both P < .001). SFH was moderately negatively correlated with bilateral SWD slope values in the anterior flexion (left: r = −0.4, P = .01; right: r = −0.7, P < .01).ConclusionsSWD imaging can be used as an adjunct tool to aid in the assessment of viscosity in LMM. Further, activity level, and position are influencing factors that should be considered in clinical practice.

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“…Previous studies 20,32 identified a moderate correlation between viscosity and elasticity in the thyroid and kidneys. However, our study provided more conclusive findings.…”

Section: Discussionmentioning

confidence: 91%

“…SWD indirectly reflects the degree of tissue viscoelasticity by directly measuring SWD slope values. SWD has been used in human liver 19 and thyroid 20 and animal muscle injury modeling 21 studies. However, SWD as an imaging technique is still in the early stages of exploration.…”

mentioning

confidence: 99%

Quantitative Evaluation of the Lumbar Multifidus Muscle by Shear Wave Dispersion in Healthy Adults: A Preliminary Study

Chen,

Li,

Deng

et al. 2024

J of Ultrasound Medicine

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“…As a first step in evaluating thyroid viscosity, the viscosity of normal thyroid tissue was previously evaluated recently by two studies. It was established to be around 2.42 ± 0.41 Pa·s in the first study, which evaluated 121 healthy subjects [ 13 ] and 2.63 ± 0.47 Pa·s in the second study on 85 healthy volunteers [ 14 ]. Both studies estimated thyroid viscosity using the Vi PLUS method provided by the SuperSonic device and a curvilinear probe.…”

Section: Discussionmentioning

confidence: 99%

“…The SuperSonic MACH30 machine by Hologic provides a 2D imaging mode called viscosity Plane-wave UltraSound (Vi PLUS), a novel tool that allows the visualization and measurement of tissue viscosity inside an area of interest selected by the operator and quantified in Pascal seconds (Pa·s) [ 11 , 12 ]. A range of values for normal thyroid tissue was previously established [ 13 , 14 ], but the technique was not yet used in patients with thyroid diseases. The aim of this study is to assess the diagnostic value of Vi PLUS in detecting autoimmune thyroiditis and its predictive value for hypothyroidism in patients with CAT.…”

Section: Introductionmentioning

confidence: 99%

Assessment of Thyroid Stiffness and Viscosity in Autoimmune Thyroiditis Using Novel Ultrasound-Based Techniques

et al. 2023

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The estimation of viscosity by measuring the shear-wave dispersion (SWD) using ultrasound 2D shear-wave elastography (SWE) is becoming more and more popular. Recent research suggests that SWD can be used in addition to 2D-SWE (shear-wave speed) to diagnose diffuse liver disease. Viscosity was studied for the assessment of normal thyroid tissue. This study aims to evaluate the use of viscosity measurements in patients with chronic autoimmune thyroiditis using the SuperSonic MACH®30 ultrasound machine (Hologic SuperSonic Imagine, Aix-en-Provence, France) which provides the Vi PLUS mode for viscosity and the 2D SWE PLUS mode for shear-wave speed measurements. Valid measurements were obtained in 308 cases, 153 with chronic autoimmune thyroiditis (CAT) and 155 with no thyroid pathology (95.95% feasibility of the methods). The differences between the healthy group and the CAT group were statistically significant both for Vi PLUS (2.5 ± 0.4 vs. 2.8 ± 0.5, p < 0.0001) and for 2D-SWE PLUS (13.5 ± 3.3 vs. 23.1 ± 8.3, p < 0.0001). The diagnostic performance was poor for Vi PLUS alone (AUC = 0.69; cut-off > 2.5 Pa·s, se = 68.6%; sp = 64.52%) and good for 2D-SWE PLUS alone (AUC = 0.861; cut-off > 18.4 kPa, se = 69.9%; sp = 92.2%). Vi PLUS correlated with 2D-SWE PLUS, with the presence of CAT, the thyroid volume, levothyroxine replacement therapy and age. Statistically significant differences were found between the CAT subgroup receiving thyroid replacement therapy and the subgroup without therapy: 24.74 ± 8.33 vs. 21.93 ± 8.12 kPa for 2D-SWE (p = 0.0380) and 3 ± 0.5 vs. 2.7 ± 0.4 Pa·s for Vi PLUS (p = 0.0193). Elastography-based methods improve the classic ultrasound evaluation: 2D-SWE PLUS performed somewhat better in distinguishing CAT from normal thyroid tissue, while Vi PLUS made a slightly better assessment regarding the functional status.

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“…The cutoff value for thyroid tissue elasticity obtained from real-time ultrasound elastography for diagnosing HT showed 96% sensitivity and 67% specificity in adults[ 91 ], as well as 97.4% sensitivity and 100% specificity in children[ 92 ]. Based on ultrasound 2D shear-wave elastography, thyroid stiffness measured by shear-wave dispersion performed somewhat better in diagnosing HT than thyroid viscosity measured by shear-wave dispersion[ 93 ]. Compared with conventional ultrasound examination, high-frequency ultrasonic elastography exhibited a significantly higher diagnostic accuracy of HT (sensitivity, 92.16%; specificity, 92.86%; NPV, 86.67%; PPV, 95.92%)[ 94 ].…”

Section: Ultrasonography Application In Aitdmentioning

confidence: 99%

Association of autoimmune thyroid disease with type 1 diabetes mellitus and its ultrasonic diagnosis and management

Wang,

Wan,

Chang

et al. 2024

World J Diabetes

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As a common hyperglycemic disease, type 1 diabetes mellitus (T1DM) is a complicated disorder that requires a lifelong insulin supply due to the immune-mediated destruction of pancreatic β cells. Although it is an organ-specific autoimmune disorder, T1DM is often associated with multiple other autoimmune disorders. The most prevalent concomitant autoimmune disorder occurring in T1DM is autoimmune thyroid disease (AITD), which mainly exhibits two extremes of phenotypes: hyperthyroidism [Graves' disease (GD)] and hypo-thyroidism [Hashimoto's thyroiditis, (HT)]. However, the presence of comorbid AITD may negatively affect metabolic management in T1DM patients and thereby may increase the risk for potential diabetes-related complications. Thus, routine screening of thyroid function has been recommended when T1DM is diagnosed. Here, first, we summarize current knowledge regarding the etiology and pathogenesis mechanisms of both diseases. Subsequently, an updated review of the association between T1DM and AITD is offered. Finally, we provide a relatively detailed review focusing on the application of thyroid ultrasonography in diagnosing and managing HT and GD, suggesting its critical role in the timely and accurate diagnosis of AITD in T1DM.

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Quantification of Thyroid Viscosity in Healthy Subjects Using Ultrasound Shear Wave Dispersion (Viscosity PLUS)

Cited by 4 publications

References 37 publications

Quantitative Evaluation of the Lumbar Multifidus Muscle by Shear Wave Dispersion in Healthy Adults: A Preliminary Study

Quantitative Evaluation of the Lumbar Multifidus Muscle by Shear Wave Dispersion in Healthy Adults: A Preliminary Study

Assessment of Thyroid Stiffness and Viscosity in Autoimmune Thyroiditis Using Novel Ultrasound-Based Techniques

Association of autoimmune thyroid disease with type 1 diabetes mellitus and its ultrasonic diagnosis and management

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