Quantification of tissue distribution of antibiotics by kinetic hysteresis analysis

Abstract

Distribution of antibiotics can be described by kinetic hysteresis analysis when concentrations are measured in the serum and an extravascular sampling site. By calculating the area of the hysteresis loop (a simple formula is presented), the relative amount of drug transferred to an extravascular site can be quantified. With this approach, changes in disposition characteristics can be evaluated under various pathophysiological conditions. In addition, a specific distribution coefficient may be derived for any drug when different dose levels are studied under identical conditions. Kinetic hysteresis analysis overcomes the drawback of conventional compartment model pharmacokinetic analysis, since no simultaneous fitting of two different concentration-time courses is feasible.

Gravireception in Phycomyces Blakesleeanus and Arabidopsis Thaliana: Hysteretic Behavior of Primary Reactions

“…In these cases memory storage can occur through the coupling of common enzyme properties with diffusion as a limiting parameter (Thomas et al 1977) and-in the case of transport across membranes-the loop area can be used to estimate the amount of molecules transferred through the barrier (Ganzinger and Neumann 1992).…”