Quantification of Total Oxidant Scavenging Capacity of Antioxidants for Peroxynitrite, Peroxyl Radicals, and Hydroxyl Radicals

Regoli, Francesco; Winston, Gary W.

doi:10.1006/taap.1999.8637

Cited by 376 publications

(225 citation statements)

References 40 publications

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“…Thus, all in between partially reduced states of oxygen give rise to active/reactive oxygen species (Blokhina et al 2003). In general, accumulation of ROS, decreased activity of antioxidants and antioxidative enzymes, increased lipid peroxdation, membrane damage and tissue leakage are the major causes of less shelf-life of fruits (Mondal et al 2004;Regoli and Winston 1999) during ripening and storage. The results during the present investigation for antioxidative isozymes were as follow:…”

Section: Resultsmentioning

confidence: 99%

“…One of the important areas in this direction appears to be that of scavenging of reactive oxygen species (ROS) normal metabolism as byproducts of inevitable leakage of electrons on molecular oxygen during the electron transport activities in chloroplast, mitochondria and plasma membrane (Foyer 1997;Kumar and Malhotra 2008;Kumar et al 2010a, b). Accumulation of ROS is linked to deteriorative changes such as DNA mutation, protein denaturation, enzyme inactivation and lipid peroxidation (Regoli and Winston 1999). Accumulation and overproduction of ROS is generally high during various stress conditions.…”

Section: Introductionmentioning

confidence: 99%

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Isozymes of antioxidative enzymes during ripening and storage of ber (Ziziphus mauritiana Lamk.)

et al. 2011

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Isozyme profile of antioxidative enzymes viz. superoxide dismutase (SOD), peroxidase (POX), catalase (CAT) and ascorbate peroxidase (APX) was studied during ripening and storage of two cultivars of ber fruit (Ziziphus mauritiana Lamk.) differing in their shelf-lives viz. Umran (shelf-life, 8-9 d) and Kaithali (shelf-life, 4-5 d). The profile revealed that Umran variety exhibited three bands each of SOD and POX while in Kaithali, these enzymes had two isoenzymes throughout ripening. CAT and APX, however, showed two isozymes each during ripening of both the varieties and the pattern remained the same at all the stages of ripening except at the initial stage i.e immature green stage where single CAT isozyme was visible. During storage, one extra band each of SOD and POX present only in Umran got disappeared at later stages of storage, whereas in Kaithali, the pattern remained unchanged. Also, there was no change in the pattern of CAT and APX isozymes during storage of both the varieties. One isozyme of CAT could be considered as ripening related while one isozyme each of SOD and POX could be related to higher shelf life of fruits.

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Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Isozymes of antioxidative enzymes during ripening and storage of ber (Ziziphus mauritiana Lamk.)

et al. 2011

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“…Uric acid is the final product of the catabolism of purine [42]. The levels of uric acid in most mammals are lower than in humans due to the presence of uricase, a liver enzyme that degrades uric acid into allantoin [43].…”

Section: Somentioning

confidence: 99%

Effect of Sodium Metabisulphite on Blood Metabolic Status of Wistar Rats

Kadi¹,

Benali²,

Bénali³

et al. 2014

FNS

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The objective of this work was to determine the sodium metabisulphite (NaMBS) subchronic toxicity used as a food additive in Algeria. Three groups of female Wistar rats were treated with 0.25%, 1% and 4% of NaMBS in their drinking water for 90 days. An immunization protocol was conducted during the experiment. Mortality, comportmental and weight modifications, and food and water consumption were recorded. At the end of the experiment, the control and experiment rats were killed, and their blood and organs were removed. Immunoglobulin levels were evaluated; biochemical and hematological parameters were investigated. Our results showed that the administration of NaMBS at 1% and 4% had significant effects on body weight, food and water consumed. There was an increase in biochemical parameters (calcium, urea, creatinine, uric acid, transaminases) and decrease immunoglobulin levels. The hematology revealed a decrease in red blood cells and hemoglobin, as well as leucocytosis. Physiological study showed enlarged spleen, kidney, liver and stomach. In light of our results, we can conclude that subchronic intake of NaMBS 1% and 4% seems to alter immune function, biochemical, hematological and physiological parameters in Wistar rats.

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“…The application of ischemic preconditioning maintained vascular responses following ischemia/reperfusion, and an infusion of PN could mimic the beneficial effects of precondi-tioning. However, the beneficial effects of PN infusion on vascular responses following ischemia/reperfusion injury could not be reduced in the presence of uric acid, a PN scavenging agent [167,305,306]. Moreover, the use of the PARS inhibitors, 3-aminobenzamid or nicotinamide, reversed the beneficial effects of ischemia and PN preconditioning [304].…”

Section: Protective Effect Of Peroxynitrite In Ischemia Reperfusion Imentioning

confidence: 99%

Potential Benefits of Peroxynitrite

Nossaman

Kadowitz²

2008

TOPHARMJ

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Peroxynitrite (PN) is generated by the reaction of nitric oxide (NO) and superoxide in one of the most rapid reactions in biology. Studies have reported that PN is a cytotoxic molecule that contributes to vascular injury in a number of disease states. However, it has become apparent that PN has beneficial effects including vasodilation, inhibition of platelet aggregation, inhibition of inflammatory cell adhesion, and protection against ischemia/reperfusion injury in the heart. It is our hypothesis that PN may serve to inactivate superoxide and prolong the actions of NO in the circulation. This manuscript reviews the beneficial effects of PN in the cardiovascular system. Keywords:Nitric oxide/*metabolism, nitric oxide synthase/metabolism/physiology, peroxynitrous acid/metabolism, reactive nitrogen species/metabolism, reactive oxygen species/metabolism, endothelium, vascular/drug effects/metabolism, muscle, smooth, vascular/drug effects/*metabolism, vasodilator agents/adverse effects, oxidative stress/*physiology, vasodilation/drug effects.

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Quantification of Total Oxidant Scavenging Capacity of Antioxidants for Peroxynitrite, Peroxyl Radicals, and Hydroxyl Radicals

Cited by 376 publications

References 40 publications

Isozymes of antioxidative enzymes during ripening and storage of ber (Ziziphus mauritiana Lamk.)

Isozymes of antioxidative enzymes during ripening and storage of ber (Ziziphus mauritiana Lamk.)

Effect of Sodium Metabisulphite on Blood Metabolic Status of Wistar Rats

Potential Benefits of Peroxynitrite

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