Quantified Retinal Morphology and Its Association With Papilledema and Visual Acuity in Syndromic and Complex Craniosynostosis: An Optical Coherence Tomography Study

Ottelander, Bianca K. den; Beeten, Stephanie D. C. van de; Yang, Sumin; Rizopoulos, Dimitris; Veelen, M.L.C. van; Mathijssen, Irene M.J.; Loudon, Sjoukje E.

doi:10.1016/j.ajo.2021.08.014

Cited by 4 publications

(6 citation statements)

References 28 publications

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“…Ten use papilledema as the only method to determine ICH, 28,30,32,33,36,37,39,43,81,82 7 studies use papilledema alongside other indirect methods to determine ICH 26,27,29,31,34,40,80 . Four studies report on the prevalence of papilledema, but do not associate it with ICH, 35,56,86,88 1 study uses OCT as determinant of ICH and compares it with papilledema 42 …”

Section: Resultsmentioning

confidence: 99%

“…After screening full texts, against eligibility criteria, we had 90 articles that were analyzed 2–91 . The PRISMA flow diagram depicted in Fig.…”

Section: Methodsmentioning

confidence: 99%

“…Ten use papilledema as the only method to determine ICH, 28,30,32,33,36,37,39,43,81,82 7 studies use papilledema alongside other indirect methods to determine ICH. 26,27,29,31,34,40,80 Four studies report on the prevalence of papilledema, but do not associate it with ICH, 35,56,86,88 1 study uses OCT as determinant of ICH and compares it with papilledema. 42 Five studies compared invasive ICH/LP measurements with papilledema in 125 sCS patients, 5,21,22,85,89 and showed that the sensitivity of papilledema to detect ICH (as determined by invasive ICP/LP measurement) is not that high, ranging between 11% and 32%.…”

Section: Fundoscopy-papilledemamentioning

confidence: 99%

“…36 One study used OCT alone to determine ICH, 42 4 used OCT alongside direct ICP/LP measurements, [12][13][14][15] and none used OCT alongside indirect methods. Two studies used OCT but did not relate it to ICH, 35,88 one of which associated OCT with visual acuity. 88…”

Section: Optical Coherence Tomography (Oct)mentioning

confidence: 99%

“…Two studies used OCT but did not relate it to ICH, 35,88 one of which associated OCT with visual acuity. 88…”

Section: Optical Coherence Tomography (Oct)mentioning

confidence: 99%

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What We Know About Intracranial Hypertension in Children With Syndromic Craniosynostosis

Doerga

Goederen

Veelen

et al. 2023

Journal of Craniofacial Surgery

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Objective: A scoping review of literature about mechanisms leading to intracranial hypertension (ICH) in syndromic craniosynostosis (sCS) patients, followed by a narrative synopsis of whether cognitive and behavioral outcome in sCS is more related to genetic origins, rather than the result of ICH. Methods: The scoping review comprised of a search of keywords in EMBASE, MEDLINE, Web of science, Cochrane Central Register of Trials, and Google scholar databases. Abstracts were read and clinical articles were selected for full-text review and data were extracted using a structured template. A priori, the authors planned to analyze mechanistic questions about ICH in sCS by focusing on 2 key aspects, including (1) the criteria for determining ICH and (2) the role of component factors in the Monro-Kellie hypothesis/doctrine leading to ICH, that is, cerebral blood volume, cerebrospinal fluid (CSF), and the intracranial volume. Results: Of 1893 search results, 90 full-text articles met criteria for further analysis. (1) Invasive intracranial pressure measurements are the gold standard for determining ICH. Of noninvasive alternatives to determine ICH, ophthalmologic ones like fundoscopy and retinal thickness scans are the most researched. (2) The narrative review shows how the findings relate to ICH using the Monro-Kellie doctrine. Conclusions: Development of ICH is influenced by different aspects of sCS: deflection of skull growth, obstructive sleep apnea, venous hypertension, obstruction of CSF flow, and possibly reduced CSF absorption. Problems in cognition and behavior are more likely because of genetic origin. Cortical thinning and problems in visual function are likely the result of ICH.

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Section: Resultsmentioning

confidence: 99%

“…After screening full texts, against eligibility criteria, we had 90 articles that were analyzed 2–91 . The PRISMA flow diagram depicted in Fig.…”

Section: Methodsmentioning

confidence: 99%

Section: Fundoscopy-papilledemamentioning

confidence: 99%

Section: Optical Coherence Tomography (Oct)mentioning

confidence: 99%

“…Two studies used OCT but did not relate it to ICH, 35,88 one of which associated OCT with visual acuity. 88…”

Section: Optical Coherence Tomography (Oct)mentioning

confidence: 99%

See 3 more Smart Citations

What We Know About Intracranial Hypertension in Children With Syndromic Craniosynostosis

Doerga

Goederen

Veelen

et al. 2023

Journal of Craniofacial Surgery

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Sensitivity, Specificity, and Cutoff Identifying Optic Atrophy by Macular Ganglion Cell Layer Volume in Syndromic Craniosynostosis

Chang,

Staffa,

Yavuz Saricay

et al. 2024

Ophthalmology

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Quantitative Detection and Follow-Up of Intracranial Hypertension in Craniosynostosis: An Optical Coherence Tomography Study

den Ottelander,

van de Beeten,

Yang

et al. 2023

Plastic &Amp; Reconstructive Surgery

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Background/purpose: To evaluate in craniosynostosis: 1) the diagnostic accuracy of fundoscopy and optical coherence tomography (OCT) to detect intracranial hypertension (ICH); 2) the time course of retinal thickness after treatment of ICH; and 3) the relation between high hyperopia (HH) and fundoscopy/OCT scan findings. Methods: Syndromic, multisuture, unicoronal, unilambdoid and sagittal synostosis patients visiting our national center were included in this longitudinal cohort study and formed a consecutive series. Retinal layers on OCT, OCT fundus image and fundoscopy were evaluated. ICH was scored according to presence of abnormal intracranial pressures, hydrocephalus, progressive cerebellar tonsillar herniation or fingerprinting and growth arrest. Diagnostic accuracy of OCT, fundoscopy and fundus image, the time course of retinal thickness after ICH and interference of HH were analyzed using linear mixed models. Results: 577 OCT scans in 307 patients were included. ICH was found in 7.2%. Combining total retinal thickness (TRT), OCT fundus image and fundoscopy resulted in a sensitivity of 76% and 81% specificity to detect signs of ICH. TRT was increased in patients who have had signs of ICH versus patients who never had signs of ICH (β+44.9 µm in patients who have had ICH, 95%CI 9.0-80.8,P=0.01). TRT decreased to normal in the years after surgery (β -3.6 µm/year, 95%CI -7.2 - -0.05, P=0.047). There were greater odds of having increased TRT in patients with HH (OR 2.9, 95%CI 1.1-7.6,P=0.03). Conclusions: The correlation between TRT, OCT fundus image, fundoscopy and particularly for the combination of these parameters with ICP surrogate markers is fair. Increased TRT in the presence of a clinical suspicion of ICH warrants further screening.

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Quantified Retinal Morphology and Its Association With Papilledema and Visual Acuity in Syndromic and Complex Craniosynostosis: An Optical Coherence Tomography Study

Cited by 4 publications

References 28 publications

What We Know About Intracranial Hypertension in Children With Syndromic Craniosynostosis

What We Know About Intracranial Hypertension in Children With Syndromic Craniosynostosis

Sensitivity, Specificity, and Cutoff Identifying Optic Atrophy by Macular Ganglion Cell Layer Volume in Syndromic Craniosynostosis

Quantitative Detection and Follow-Up of Intracranial Hypertension in Craniosynostosis: An Optical Coherence Tomography Study

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