Quantifying 6D tumor motion and calculating PTV margins during liver stereotactic radiotherapy with fiducial tracking

Sun, Xingru; Dai, Zhitao; Xu, Meiling; Guo, Xueling; Su, Huanfan; Li, Yang

doi:10.3389/fonc.2022.1021119

Cited by 3 publications

(1 citation statement)

References 57 publications

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“…The coordinates of fiducials in the patient coordinate system (p, q, z) could be obtained from that in the image coordinate system (x, y, z), as was indicated in Figure 1(b) and (c). For details of the algorithm, please refer to Li et al (2019); Sun et al (2022).…”

Section: Introductionmentioning

confidence: 99%

Precise Fiducial Marker Placement for Cyberknife Stereotactic Radiosurgery of Superficial Tumor

Huang,

Wang,

Chen

et al. 2023

Preprint

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Section: Introductionmentioning

confidence: 99%

Precise Fiducial Marker Placement for Cyberknife Stereotactic Radiosurgery of Superficial Tumor

Huang,

Wang,

Chen

et al. 2023

Preprint

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The effect of intra- and inter-fractional motion on target coverage and margins in proton therapy for uveal melanoma

Björkman,

Via,

Lomax

et al. 2024

Phys. Med. Biol.

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Introduction: This study aims to assess the effective lateral margin requirements for target coverage in ocular proton therapy (OPT), considering the unique challenges posed by eye motion and hypofractionation. It specifically addresses the previously unaccounted-for uncertainty contribution of intra-fractional motion, in conjunction with setup uncertainties, on dosimetric determination of lateral margin requirements. Method: The methodology integrates dose calculations from the in-house developed treatment planning system OCULARIS with measured intra-fractional motion, patient models from EyePlan and Monte Carlo (MC) sampling of setup uncertainties. The study is conducted on 16 uveal melanoma patients previously treated in the OPTIS2 treatment room at the Paul Scherrer Institute (PSI).Results:The retrospective simulation analysis highlights a significant impact of non-systematic factors on lateral margin requirements in OPT. Simulations indicate that reducing the 2.5 mm clinical lateral margin, represented by a 2.1 mm margin in this work, would have resulted in inadequate target coverage for two patients, revealing a greater impact of non-systematic factors on lateral margin requirements. Conclusions:This work characterizes intra-fractional motion in 16 OPT patients and identifies limitations of clinical margin selection protocols for OPT applications. A novel framework was introduced to assess margin sufficiency for target coverage. The findings suggest that prior research underestimated non-systematic factors and overestimated systematic contributions to lateral margin components. This re-evaluation highlights the critical need to prioritize the management of non-systematic uncertainty contributions in OPT.

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Precise Fiducial Marker Placement for CyberKnife Stereotactic Radiosurgery of Superficial Tumor

Huang,

Wang,

Chen

et al. 2024

Preprint

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The CyberKnife, a renowned non-invasive stereotactic radiotherapy technique, has gained widespread adoption for its effective treatment of various cancers. The success of CyberKnife treatment relies significantly on the accurate placement of fiducial markers. This study introduces a Fiducial marker placement planning algorithm, specifically for superficial tumors that are located 20-50 mm beneath the epidermis. Three patients with treatment sites of thymus, breast, and submandibular gland were retrospectively selected for this study. The algorithm proposes numerous potential implantation sites by constructing and optimizing a B-spline surface. The site selection is predominantly based on the distance between markers, the angles among them, and the necessity for all fiducial markers to be visible in 45° oblique views without overlap. By leveraging the kd-tree, we enhanced spatial querying and addressed the challenge using graph theory, specifically through the Bron-Kerbosch algorithm. The time complexity of the algorithm proposed in this study is \(O(m\log m + m^2 + 3^{\frac{n}{3}})\), significantly faster than the brute-force \(O(n^3)\) approach. Experimental outcomes show that our algorithm can efficiently plan Fiducial marker placements, simplifying the planning process and providing valuable technical support for CyberKnife treatments.

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Quantifying 6D tumor motion and calculating PTV margins during liver stereotactic radiotherapy with fiducial tracking

Cited by 3 publications

References 57 publications

Precise Fiducial Marker Placement for Cyberknife Stereotactic Radiosurgery of Superficial Tumor

Precise Fiducial Marker Placement for Cyberknife Stereotactic Radiosurgery of Superficial Tumor

The effect of intra- and inter-fractional motion on target coverage and margins in proton therapy for uveal melanoma

Precise Fiducial Marker Placement for CyberKnife Stereotactic Radiosurgery of Superficial Tumor

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