2011
DOI: 10.2967/jnumed.110.083865
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Quantifying and Reducing the Effect of Calibration Error on Variability of PET/CT Standardized Uptake Value Measurements

Abstract: The purpose of this study was to measure the errors introduced by regular calibration of PET/CT scanners and to minimize the effect of calibration error on standardized uptake value measurements. Methods Global calibration factors from 2 PET/CT scanners were recorded for 3.5 and 1.8 y, comparing manufacturer-recommended protocols with modified protocols to evaluate error contributions due to operator-influenced procedures. Dose calibrator measurements were evaluated using National Institute of Standards and T… Show more

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Cited by 63 publications
(51 citation statements)
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“…Interestingly, when precision errors for measurements in single lumbar vertebrae were compared with those for L 1 -L 4 , they were almost unchanged despite the 4 times smaller volume of bone. This finding suggests that the size of the precision error is set by the calibration of the PET scanner rather than by counting statistics (26).…”
Section: Discussionmentioning
confidence: 96%
“…Interestingly, when precision errors for measurements in single lumbar vertebrae were compared with those for L 1 -L 4 , they were almost unchanged despite the 4 times smaller volume of bone. This finding suggests that the size of the precision error is set by the calibration of the PET scanner rather than by counting statistics (26).…”
Section: Discussionmentioning
confidence: 96%
“…This could not be achieved in our study as most patients had staging PET-CT scans upon presentation to our clinic. However, PET-CT scanners at our institution are routinely calibrated and typically differ by an average of 5 -7%, similar to studies comparing inter-scan variability (20,21).…”
Section: Discussionmentioning
confidence: 76%
“…There are many steps toward the clinical utility of 18 F-FDG PET/ CT for early response assessment, including demonstration of fidelity of 18 F-FDG PET across multiple platforms (13)(14)(15), appropriate pairing of tracer and metabolic pathway, convincing tissue correlates, and proof of feasibility in a multicenter trial. In this context, we applaud the work of the Hopkins group and TBCRC for using a uniform imaging protocol and careful standardization of study phantoms to certify sites with careful central review of the images.…”
Section: See Page 31mentioning
confidence: 99%