2020
DOI: 10.1371/journal.pone.0241707
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Quantifying cognitive resilience in Alzheimer’s Disease: The Alzheimer’s Disease Cognitive Resilience Score

Abstract: Even though there is a clear link between Alzheimer’s Disease (AD) related neuropathology and cognitive decline, numerous studies have observed that healthy cognition can exist in the presence of extensive AD pathology, a phenomenon sometimes called Cognitive Resilience (CR). To better understand and study CR, we develop the Alzheimer’s Disease Cognitive Resilience Score (AD-CR Score), which we define as the difference between the observed and expected cognition given the observed level of AD pathology. Unlike… Show more

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Cited by 21 publications
(18 citation statements)
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“…21 Up to date, only a few studies have explored the contribution of physical activity to cognitive reserve while accounting for brain pathology. 22,[24][25][26]28,29,45 They yielded heterogeneous findings.…”
Section: Lowmentioning
confidence: 99%
“…21 Up to date, only a few studies have explored the contribution of physical activity to cognitive reserve while accounting for brain pathology. 22,[24][25][26]28,29,45 They yielded heterogeneous findings.…”
Section: Lowmentioning
confidence: 99%
“…Recent reports indicate Black and Hispanic populations are disproportionately more likely to have AD compared to older white Americans (64), which highlights a potential limitation of the current study. In addition to population demographics, the use of multiple definitions of resilience and how researchers identify this group adds complexity to generalizable interpretation of findings (7, 8). The current study used the combination of pathological and cognitive metrics to differentiate asymptomatic from symptomatic cases by imposing cutoffs which would identify resilient cases with the greatest confidence, however, there may be more to learn from cases not captured by this strategy.…”
Section: Discussionmentioning
confidence: 99%
“…This is a staging tool crucial to determine whether an individual is diagnosed as MCI or AD, and is usually complemented by the Mini Mental State Examination (MMSE) score, which measures overall cognitive status. For instance, the study by Yao and colleagues (2020 [ 60 ]. described the use of a ML model (GB and SVM) that helped to generate a cognitive resilience score, which they defined as the difference between the observed and expected cognitive status displayed by an AD patient with a specific presumed level of AD pathology.…”
Section: Main Applications Of Ai In Ad Researchmentioning
confidence: 99%