Quantifying low levels (&lt;0.5% w/w) of warfarin sodium salts in oral solid dose forms using Transmission Raman spectroscopy

Griffen, Julia A.; Owen, Andrew W.; Matousek, Pavel

doi:10.1016/j.jpba.2018.04.008

Cited by 18 publications

(6 citation statements)

References 28 publications

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“…There exist several instrumental configurations to address this point, for example, applying an imaging technique by means of a multi‐spot detection geometry. [ 64 ] A different approach has been presented by Griffen et al [ 65 ] who used transmission Raman spectroscopy to obtain chemically specific information of large sampling volumes from solid samples in tablet form. In both cases, data analysis by means of multivariate statistics enabled to achieve detection limits of the respective target substances of less than 1 g/kg.…”

Section: Resultsmentioning

confidence: 99%

Shifted excitation Raman difference spectroscopy as enabling technique for the analysis of animal feedstuff

Sowoidnich

Oster

Wimmers

et al. 2021

J Raman Spectroscopy

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To achieve the best performance and health in farm animals, high-quality pellets should be applied for feeding. Raw materials used for pellet production can have a significant influence on the nutritive and physical characteristics of the final product. A comprehensive quality control of raw materials and pellets is therefore essential. Optical inspection techniques show great promise as they enable fast, simple, and non-destructive analysis. This study demonstrates the potential of shifted excitation Raman difference spectroscopy (SERDS) for inspection of intact feed pellets and their constituents. SERDS combines the ability of conventional Raman spectroscopy to obtain chemically specific information from the sample with efficient fluorescence background rejection capabilities. The latter is an essential prerequisite for the application to highly fluorescent natural samples, for example, feedstuffs. A custom dual-wavelength diode laser with two slightly shifted emission wavelengths (785.2 and 784.6 nm) as required for SERDS is used as excitation light source. Results demonstrate that Raman signals can efficiently be separated from unwanted background contributions allowing for qualitative spatially resolved analysis of chicken feed pellets. Individual constituents present at levels down to 10 g/kg were successfully detected by means of their characteristic spectral signature. This highlights the large potential of SERDS and could pave the way for future inspection of raw materials and pellets at selected points along the process chain.

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Section: Resultsmentioning

confidence: 99%

Shifted excitation Raman difference spectroscopy as enabling technique for the analysis of animal feedstuff

Sowoidnich

Oster

Wimmers

et al. 2021

J Raman Spectroscopy

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“…for drug sensing [33][34][35][36][37][38][39] in forensics [28,29,31,40] and in the pharmaceutical industry [32]. For example, transmission Raman-based methods enable at-line or on-line analysis of bulk content of tablets [41][42][43] or active pharmaceutical ingredients (APIs) of other solid dosage forms [44]. This technique reached a high level of applicability [44]: cost-savings have been demonstrated in real-world use [45], and considerations for regulatory submission are being discussed [46] for pharmaceutical applications.…”

Section: Introductionmentioning

confidence: 99%

“…For example, transmission Raman-based methods enable at-line or on-line analysis of bulk content of tablets [41][42][43] or active pharmaceutical ingredients (APIs) of other solid dosage forms [44]. This technique reached a high level of applicability [44]: cost-savings have been demonstrated in real-world use [45], and considerations for regulatory submission are being discussed [46] for pharmaceutical applications. However, conventional Raman scattering is a very weak process, limiting its use in on-site and point-of-care applications.…”

Section: Introductionmentioning

confidence: 99%

Recent advances in nano-photonic techniques for pharmaceutical drug monitoring with emphasis on Raman spectroscopy

Knebl

Frosch

2019

Nanophotonics

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Innovations in Raman spectroscopic techniques provide a potential solution to current problems in pharmaceutical drug monitoring. This review aims to summarize the recent advances in the field. The developments of novel plasmonic nanoparticles continuously push the limits of Raman spectroscopic detection. In surface-enhanced Raman spectroscopy (SERS), these particles are used for the strong local enhancement of Raman signals from pharmaceutical drugs. SERS is increasingly applied for forensic trace detection and for therapeutic drug monitoring. In combination with spatially offset Raman spectroscopy, further application fields could be addressed, e.g. in situ pharmaceutical quality testing through the packaging. Raman optical activity, which enables the thorough analysis of specific chiral properties of drugs, can also be combined with SERS for signal enhancement. Besides SERS, micro- and nano-structured optical hollow fibers enable a versatile approach for Raman signal enhancement of pharmaceuticals. Within the fiber, the volume of interaction between drug molecules and laser light is increased compared with conventional methods. Advances in fiber-enhanced Raman spectroscopy point at the high potential for continuous online drug monitoring in clinical therapeutic diagnosis. Furthermore, fiber-array based non-invasive Raman spectroscopic chemical imaging of tablets might find application in the detection of substandard and counterfeit drugs. The discussed techniques are promising and might soon find widespread application for the detection and monitoring of drugs in various fields.

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“…Transmission Raman spectroscopy (TRS) is an emerging technique, capable of quantitative analysis of API in drug products. 1–4 It is nondestructive, therefore no sample preparation and consumables are needed, which provides cost-effective and environmentally friendly opportunities for in-line, on-line, and off-line applications. In addition, it does not require extensive training to operate, and the routine sample analysis is rapid.…”

Section: Introductionmentioning

confidence: 99%

Transmission Raman Spectroscopic Quantification of Active Pharmaceutical Ingredient in Coated Tablets of Hot-Melt Extruded Amorphous Solid Dispersion

et al. 2019

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Transmission Raman spectroscopy is an emerging technique, capable of quantitative analysis of drug products nondestructively using a multivariate data analysis approach. We developed and validated a chemometric method to quantify the active pharmaceutical ingredient in coated tablets of hot-melt extruded amorphous solid dispersion. A partial least squares regression (PLSR) model was developed and validated based on transmission Raman spectra data collected from coated tablet samples with variations in the content of active pharmaceutical ingredient, excipients, water content, a key oxidative degradant, milled extrudate particle size distribution, and tablet hardness. The method was proven to be accurate, linear, specific, and robust. Our work demonstrates that transmission Raman spectroscopy (TRS) is a viable, cost-effective, secondary method to high-performance liquid chromatography (HPLC) for quantitation of active pharmaceutical ingredient (API) in coated tablets of hot-melt extruded amorphous solid dispersion.

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Quantifying low levels (<0.5% w/w) of warfarin sodium salts in oral solid dose forms using Transmission Raman spectroscopy

Cited by 18 publications

References 28 publications

Shifted excitation Raman difference spectroscopy as enabling technique for the analysis of animal feedstuff

Shifted excitation Raman difference spectroscopy as enabling technique for the analysis of animal feedstuff

Recent advances in nano-photonic techniques for pharmaceutical drug monitoring with emphasis on Raman spectroscopy

Transmission Raman Spectroscopic Quantification of Active Pharmaceutical Ingredient in Coated Tablets of Hot-Melt Extruded Amorphous Solid Dispersion

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