Quantifying Rigid and Nonrigid Motion of Liver Tumors During Stereotactic Body Radiation Therapy

Xu, Qiang; Hanna, George; Grimm, Jimm; Kubicek, Gregory J.; Pahlajani, N; Asbell, Sucha O.; Fan, J; Chen, Yan; LaCouture, Tamara

doi:10.1016/j.ijrobp.2014.05.007

Cited by 52 publications

(52 citation statements)

References 28 publications

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“…While in our patient analysis, the captured motion and systematic correlation and prediction errors were in the order of those published in the literature [17][18][19][20]26,28,30], we found larger uncorrected systematic rotation errors (>2°) in 23% of our patients.…”

Section: Accepted Manuscriptsupporting

confidence: 56%

“…One or two fiducials do not allow for 3D rotation calculation and three fiducials may show incorrect rotation results due to differential motion and deformation in separate liver segments [26][27][28][29]. Out of the 46 patients, four or more fiducials were uniquely identified on the x-ray images and tracked during 100 fractions in 26 patients.…”

Section: Cyberknife Treatmentmentioning

confidence: 99%

“…Breathing-dependent fiducial rotations in the liver were reported only recently [36] and residual rotation errors were unreported for robotic liver SBRT until now [18,28]. This may very likely be due to the fact that the information is not easily accessible in the system log files and due to a large number of patients in general being treated with less than four fiducials.…”

Section: Accepted Manuscriptmentioning

confidence: 99%

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Dosimetric Implications of Residual Tracking Errors During Robotic SBRT of Liver Metastases

Chan

Grehn

Cremers

et al. 2017

International Journal of Radiation Oncology*Biology*Physics

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Section: Accepted Manuscriptsupporting

confidence: 56%

Section: Cyberknife Treatmentmentioning

confidence: 99%

Section: Accepted Manuscriptmentioning

confidence: 99%

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Dosimetric Implications of Residual Tracking Errors During Robotic SBRT of Liver Metastases

Chan

Grehn

Cremers

et al. 2017

International Journal of Radiation Oncology*Biology*Physics

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“…Only a few studies have investigated the intrafraction rotation of implanted liver markers 25, 26. Bertholet et al26 evaluated the rotations using CBCT projections and found that the population‐based means of intrafraction rotations were 3.9° (LR), 2.9° (SI) and 4.0° (AP).…”

Section: Discussionmentioning

confidence: 99%

Evaluation of the intra‐ and interfractional tumor motion and variability by fiducial‐based real‐time tracking in liver stereotactic body radiation therapy

Liang

Liu

Xue

et al. 2018

J Applied Clin Med Phys

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PurposeTumor motion amplitude varies during treatment. The purpose of the study was to evaluate the intra‐ and interfraction tumor motion and variability in patients with liver cancer treated with fiducial‐based real‐time tracking stereotactic body radiotherapy (SBRT).MethodsFourteen liver patients were treated with SBRT using a CyberKnife. Two to four fiducial markers implanted near the tumor were used for real‐time monitoring using the Synchrony system. The tumor motion information during treatment was extracted from the log files recorded by the Synchrony system. Logfile‐based amplitudes in the superior–posterior (SI), left–right (LR) and anterior–posterior (AP) directions were compared to the 4DCT‐based amplitudes. The intra‐ and interfraction amplitude variations and the incidence of baseline shifts were analyzed for 66 fractions administered to 14 patients.ResultsThe median (range) logfile‐based liver motion amplitudes for all patients were 11.9 (5.1–17.3) mm, 1.3 (0.4–4) mm and 3.8 (0.9–7.7) mm in the SI, LR and AP directions, respectively. Compared with the logfile‐based amplitude, the 4DCT‐based amplitude was underestimated (P < 0.05). The median (range) intra‐ and interfraction liver motion amplitude variations were 4.3 (1.6–6.0) mm (SI), 0.5 (0.2–2.2) mm(LR) and 1.5 (0.3–3.3) mm (AP) and 1.7 (0.5–4.6) mm (SI), 0.3 (0.1–3.0) mm (LR) and 0.7 (0.3–2.7) mm (AP), respectively. Baseline shifts exceeding 2 mm, 3 mm and 5 mm were observed in 27.3%, 7.6% and 3% of the measurements, respectively, within 10 min, and in 66.7%, 38.1% and 19%, respectively, within 30 min for the square root of the sum of the squares of the distances in the SI, LR and AP directions (3D). The tumor motion amplitude was found to be correlated with the baseline shift.ConclusionsMost patients showed significant intra‐ and interfraction liver motion amplitude variations over the entire course of radiation. More caution is needed for patients with large tumor motion amplitudes.

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“…There is an emerging need to explore this technique especially in stereotactic body radiotherapy (SBRT) for liver malignancies because liver motion due to respiration and cardiac pulsation may produce mis-registration between the target volumes and actual irradiated areas. 3,5,6 A clear and simultaneous visualization of the irradiated liver parenchyma and cancer lesions remains challenging with currently available imaging techniques, including contrast-enhanced computed tomography (CT) and MR imaging. [7][8][9][10][11][12][13] Radiationinduced changes in liver tissues hinder this visualization, particularly in acute and subacute phases after irradiation.…”

mentioning

confidence: 99%

Persistent T2*-hypointensity of the liver parenchyma after irradiation to the SPIO-accumulated liver: An imaging marker for responses to radiotherapy in hepatic malignancies

Furuta

Yamaguchi

Minami

et al. 2016

J. Magn. Reson. Imaging

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Quantifying Rigid and Nonrigid Motion of Liver Tumors During Stereotactic Body Radiation Therapy

Cited by 52 publications

References 28 publications

Dosimetric Implications of Residual Tracking Errors During Robotic SBRT of Liver Metastases

Dosimetric Implications of Residual Tracking Errors During Robotic SBRT of Liver Metastases

Evaluation of the intra‐ and interfractional tumor motion and variability by fiducial‐based real‐time tracking in liver stereotactic body radiation therapy

Persistent T2*-hypointensity of the liver parenchyma after irradiation to the SPIO-accumulated liver: An imaging marker for responses to radiotherapy in hepatic malignancies

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