Campus spatial organization has potential impact on the multidisciplinary innovation (MDI). This research aims to establish an evaluation theory and a method for MDI adaptability of campus spatial organization. Based on the literature review, it first proposes theoretical assumptions regarding the correlation among MDI abilities, social networks, and spatiotemporal behaviors of individuals on campus. Then, data on the three aspects mentioned above was collected through online survey which was conducted from February 4th to March 15th, 2020. A total of 524 valid responses were obtained from 572 undergraduates and graduates of various majors in Zijingang Campus (East) of Zhejiang University. The correlation mechanism of these aspects was empirically analyzed by structural equation model (SEM). By integrating individual data, the research generated three overall networks whose nodes are linked according to spatial proximity, behavior routine, and disciplinary connection, respectively. Furthermore, an evaluation method is proposed for MDI adaptability of the campus spatial organization, which is based on the comparison of the structural similarity of the nodes in different networks. Accordingly, the evaluation results were validated by expert ratings and user satisfaction. Finally, design strategies for the renovation of an innovative campus are discussed.