Quantifying spectral peaks in theta and gamma brain oscillations detected from long term Local Field Potential (LFP) recordings in mice

Molńar, László; Módy, István

doi:10.1109/cinti-macro49179.2019.9105288

Cited by 1 publication

(2 citation statements)

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“…During every hour of recording, we determined the average values of the spectral peaks corresponding to the θ (5–12 Hz) and γ (30–120 Hz) oscillations. 63 This long-term approach revealed novel circadian variations in the hourly spectral peaks of the two oscillations that were out of phase with each other. As shown for representative SAL-injected (SAL; Fig.…”

Section: Resultsmentioning

confidence: 98%

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Altered brain rhythms and behaviour in the accelerated ovarian failure mouse model of human menopause

Vrontou

Bédécarrats

Ayodeji

et al. 2022

Brain Communications

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To date, potential mechanisms of menopause-related memory and cognitive deficits have not been elucidated. Therefore, we studied brain oscillations, their phase-amplitude coupling, sleep and vigilance state patterns, running wheel use and other behavioral measures in a translationally valid mouse model of menopause, the 4-vinylcyclohexene-diepoxide induced accelerated ovarian failure. After accelerated ovarian failure, female mice show significant alterations in brain rhythms, including changes in the frequencies of θ (5-12 Hz) and γ (30-120 Hz) oscillations, a reversed phase-amplitude coupling, altered coupling of hippocampal sharp-wave ripples to medial prefrontal cortical sleep spindles, and reduced δ oscillation (0.5-4 Hz) synchrony between the two regions during non-REM sleep. In addition, we report on significant circadian variations in the frequencies of θ and γ oscillations, and massive synchronous δ oscillations during wheel running. Our results reveal novel and specific network alterations and feasible signs for diminished brain connectivity in the accelerated ovarian failure mouse model of menopause. Taken together, our results may have identified changes possibly responsible for some of the memory and cognitive deficits previously described in this model. Corresponding future studies in menopausal women could shed light on fundamental mechanisms underlying the neurological and psychiatric comorbidities present during this important transitional phase in women’s lives.

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Section: Resultsmentioning

confidence: 98%

“… 25 , 61 , 62 We have previously described a procedure to determine the true spectral peaks of the θ and γ oscillations. 63 Briefly, over the 12 h long raw LFP recording, we used an 8 s long sliding window in steps of 1 s (i.e. 7 s overlaps) to calculate the FFT in each of the 8 s segments.…”

Section: Methodsmentioning

confidence: 99%