2024
DOI: 10.1101/2024.08.06.606373
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Quantifying the Impact of Co-Housing on Murine Aging Studies

Alison Luciano,
Gary A. Churchill

Abstract: Analysis of preclinical lifespan studies often assume that outcome data from co-housed animals are indepen-dent. In practice, treatments, such as controlled feeding or putative life-extending compounds, are applied to whole housing units, and as a result the outcomes are potentially correlated within housing units. We consider intra-class (here, intra-cage) correlation in three published and two unpublished lifespan studies of aged mice encompassing more than 20 thousand observations. We show that the independ… Show more

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