Technical route decision making of intelligent driving has always been the focus of attention of automotive enterprises and even the industry. Firstly, this study combs the main technical routes of intelligent driving at different levels from three dimensions: development strategy, intelligence allocation and sensor combination. Then, the methodology of technical component combination is designed to disassemble different technical routes into corresponding technical component combinations. Finally, an improved evaluation model of total cost of ownership of intelligent driving is developed and the total cost of ownership of intelligent driving system under different technical routes is compared. For the development strategy, even if the function superposition can follow some research and development achievements of low-level intelligent driving, scenario-driven is still the option with lower cost and better sustainability. For intelligence allocation, collaborative intelligence can effectively reduce the cost of the vehicle compared with single-vehicle intelligence by up to 46%, but the cost reduction depends on the original on-board hardware. For sensor combination, the multi-source fusion always has the cost advantage compared with vision-only, but the advantage is more obvious in the medium-level and high-level stage of single-vehicle intelligence.