This study looks at the effects of replication on prediction variance performances of inscribe central composite design especially those without replication on the factorial and axial portion (ICCD1), inscribe central composite design with replicated axial portion (ICCD2) and inscribe central composite design whose factorial portion is replicated (ICCD3). The G-optimal, I-optimal and FDS plots were used to examine these designs. Inscribe central composite design without replicated factorial and axial portion (ICCD1) has a better maximum scaled prediction variance (SPV) at factors k = 2 to 4 while inscribe central composite design with replicated factorial portion (ICCD3) has a better maximum and average SPV at 5 and 6 factor levels. The fraction of design space (FDS) plots show that the inscribe central composite design is superior to ICCD3 and inscribe central composite design with replicated axial portion (ICCD2) from 0.0 to 0.5 of the design space while inscribe central composite design with replicated factorial portion (ICCD3) is superior to ICCD1 and ICCD2 from 0.6 to 1.0 of the design space for factors k = 2 to 4.