Quantitation by reactant ion monitoring in gas chromatography/chemical ionization mass spectrometry

Matrix effects in quantitation and identification by chemical ionization mass spectrometry

“…Few investigations of this kind have been reported. Experiments with fish have shown that uptake and accumulation take place directly from water and from food, and symptoms of toxicity have been observed (2)(3)(4)(5)(6). Determination of small amounts of CP is particularly difficult.…”

Proton transfer reactions of halogenated compounds: Using gas chromatography/Fourier transform ion cyclotron resonance mass spectrometry (GC/FT-ICR MS) and ab initio calculations

“…For example, functional group specific ionmolecule reactions, determination of the gas phase basicity (GB), or PA of an analyte, concurrent with its GC/MS analysis can in principle provide additional dimensions to improve GC/MS analysis [21,22]. In this context, we note that Munson and co-workers reported the use of reactant ion monitoring (RIM) [23] and PA bracketing [24] to determine analyte quantity and ion thermochemistry, respectively. This approach was extended for simultaneous determination of analyte concentration, gas phase basicities, and proton transfer (PT) kinetics with GC/FT-ICR MS [21].…”

Selective reagents in chemical ionization mass spectrometry: diisopropyl ether

“…Exothermic proton transfer reagents are the most widely used Cl systems. With methane, for example, CH5+ and C2H5+ react with almost all samples with near-collision efficiencies to give high and similar sensitivities, frequently with extensive fragmentation (3)(4)(5)(6).…”