Quantitation of Blomia tropicalis Allergen Blo t 5 in Cereal and Cereal-Based Foods Consumed in the Nile Delta, Egypt

Hussein, Atef; Elawamy, Waleed E.

doi:10.4269/ajtmh.14-0837

Cited by 8 publications

(6 citation statements)

References 37 publications

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“…Oral mite allergy and anaphylaxis is increasingly detected in some African nations. Blo t 5, which is a major Blomia tropicalis mite allergen was detected in several raw and processed food samples collected from retail stores in the Nile Delta of Egypt including wheat, corn, rice, bean, wheat and corn flour, cake, and rusk 62 …”

Section: Food Allergensmentioning

confidence: 99%

Challenges of managing food allergy in the developing world

Hossny

Ebisawa

El-Gamal

et al. 2019

World Allergy Organization Journal

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Food allergy (FA) is currently a significant health care problem in the developing world. Widely varying study populations and methodologies, the use of surrogate markers such as self report or hospitalization rates due to anaphylaxis rather than objective methods, limits robust estimation of FA prevalence in low income settings. Also, allergy is under-recognized as a clinical specialty in the developing world which compromises the chance for accurate diagnosis. In this review, most published data on food allergens from developing or low income countries are displayed. The diagnostic challenges and limitations of treatment options are discussed. It seems that FA is an under-appreciated health care issue in the developing world, and accurate determination of its burden in low-income settings represents an important unmet need. Multicenter surveillance studies, using standardized methodologies, are, therefore, needed to reveal the true extent of the problem and provide epidemiological clues for prevention. Preventive strategies should be tailored to fit local circumstances in different geographic regions. In addition, studying the gene environment interactions and impact of early life microbiota on the expression of FA in developing communities would be worthwhile. Efforts and resources should be directed toward public health education and training of health care providers dealing with food allergic patients.

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Section: Food Allergensmentioning

confidence: 99%

Challenges of managing food allergy in the developing world

Hossny

Ebisawa

El-Gamal

et al. 2019

World Allergy Organization Journal

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“…House dust mites are by far the most predominant allergen sources in the Tropics where populations are perennially exposed, mainly to B. tropicalis and D. pteronyssinus [ 238 ]. Since it thrives in warm and humid climates, B. tropicalis is an important allergen in tropical and subtropical regions [ 13 , 59 , 239 – 241 ]. The HDM fauna in Los Baños, Laguna, Philippines included 32 species of mites belonging to 7 families.…”

Section: Introductionmentioning

confidence: 99%

“…Samples of house dust collected from 50 homes in El-Arish city, North Sinai, Egypt, revealed that 34.6 % of the samples had mites [ 243 ]. Blo t 5 allergen was detected in 34 out of 88 raw and processed food samples including wheat, corn, rice, bean, wheat and corn flour, cake, and rusk collected from retail stores in Benha city in the Nile Delta of Egypt [ 241 ]. In some tropical areas, the majority of the homes from mite allergic patients with asthma and/or rhinitis present concentrations of group 1 allergens >10 μg/g of dust in at least one site of the house [ 244 – 246 ].…”

Section: Introductionmentioning

confidence: 99%

Particularities of allergy in the Tropics

Caraballo

Zakzuk

Lee

et al. 2016

World Allergy Organization Journal

128

145

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Allergic diseases are distributed worldwide and their risk factors and triggers vary according to geographical and socioeconomic conditions. Allergies are frequent in the Tropics but aspects of their prevalence, natural history, risk factors, sensitizers and triggers are not well defined and some are expected to be different from those in temperate zone countries. The aim of this review is to investigate if allergic diseases in the Tropics have particularities that deserve special attention for research and clinical practice. Such information will help to form a better understanding of the pathogenesis, diagnosis and management of allergic diseases in the Tropics. As expected, we found particularities in the Tropics that merit further study because they strongly affect the natural history of common allergic diseases; most of them related to climate conditions that favor permanent exposure to mite allergens, helminth infections and stinging insects. In addition, we detected several unmet needs in important areas which should be investigated and solved by collaborative efforts led by the emergent research groups on allergy from tropical countries.Electronic supplementary materialThe online version of this article (doi:10.1186/s40413-016-0110-7) contains supplementary material, which is available to authorized users.

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“…To distinguish between true cosensitization and cross-reactivity between B. tropicalis and other mites, it would be important to include more specific allergens to the common diagnostic platforms [93]. An ELISA kit for quantification of Blo t 5 in environmental samples or Blomia extracts is available from Indoor Biotechnologies [2,12,94]. …”

Section: Diagnosis and Immunotherapy Of B Tropicalismentioning

confidence: 99%

Allergens of <b><i>Blomia tropicalis</i></b>: An Overview of Recombinant Molecules

Silva¹,

Asam

Lackner

et al. 2017

Int Arch Allergy Immunol

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Allergic diseases are considered a major problem for healthcare systems in both developed and developing countries. House dust mites are well-known triggers of allergic manifestations. While the Dermatophagoides genus is widely distributed globally, Blomia tropicalis is the most prominent mite species in the tropical and subtropical regions of the world. Over the last decades, an increase in sensitization rates to B. tropicalis has been reported, leading to increased research efforts on Blomia allergens. In fact, 8 new allergens have been identified and characterized to different degrees. Here, we provide an overview of recent developments concerning the identification and production of recombinant Blomia allergens, as well as their structural and immunological characterization. Although considerable progress has been achieved, detailed molecule-based studies are still needed to better define the clinical relevance of Blomia allergens. Thus, the establishment of a well-standardized and fully characterized panel of allergens remains a challenge for the development of better diagnosis and therapy of allergic diseases induced by B. tropicalis.

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Quantitation of Blomia tropicalis Allergen Blo t 5 in Cereal and Cereal-Based Foods Consumed in the Nile Delta, Egypt

Cited by 8 publications

References 37 publications

Challenges of managing food allergy in the developing world

Challenges of managing food allergy in the developing world

Particularities of allergy in the Tropics

Allergens of <b><i>Blomia tropicalis</i></b>: An Overview of Recombinant Molecules

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