Quantitation of esophageal motor abnormalities with ambulatory 24-hour esophageal manometry

Stein, Helga; DeMeester, Tom R.

doi:10.1016/0016-5085(92)91684-v

Cited by 1 publication

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“…Bumm et al found that irregular or high amplitude contractions were more prevalent in patients with gastroesophageal reflux disease (8). Others have found that adults with GERD have more isolated, double-peaked contractions and simultaneous contractions than controls (14,15). The clinical significance of abnormal esophageal body motor contractions has been evaluated with simultaneous esophageal pH and fluoroscopic studies.…”

Section: Discussionmentioning

confidence: 99%

Esophageal Motor Activity in Children with Gastro‐esophageal Reflux Disease and Esophagitis

Chitkara,

Fortunato,

Nurko

2005

J. pediatr. gastroenterol. nutr.

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Objective:To evaluate esophageal body motor contractions occurring during esophageal reflux in pediatric patients with gastro‐esophageal reflux disease (GERD).Methods:Patients referred for the evaluation of GERD who were evaluated with combined 24‐hour pH probe and esophageal manometry test (MP24) were included. Patients were separated into the following groups: Group C ‐ normal pH probe and normal EGD; Group 1 ‐ abnormal pH probe and normal EGD; and Group 2 ‐ abnormal pH probe and EGD with histologic esophagitis. Esophageal motor function during reflux episodes was analyzed.Results:Twenty‐five patients were included. All had a normal stationary esophageal manometry. Patients in Groups 1 and 2 had significantly more gastroesophageal reflux by pH probe than Group C (P < 0.01). During the MP24, patients in Group 1 and 2 had significantly fewer contractions per minute pre‐, during, and post‐GER (P < 0.05). There were significant differences in the number of isolated and prolonged contractions (>7 sec) during prolonged GERD episodes >5 minutes (P < 0.05).Conclusion:Children with GERD have a decreased number and abnormal esophageal body contractions with esophageal reflux. This suggests that children with GERD with and without esophagitis have impaired esophageal body acid clearance.

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Section: Discussionmentioning

confidence: 99%