Quantitation of Lipophilic Chloroethylnitrosourea Cancer Chemotherapeutic Agents

Weinkam, Robert J.; Liu, Tsui-Yun J.

doi:10.1002/jps.2600710204

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Assays Of Chemical and Biological Parameters Lipophilicity A...1

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1983

2011

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Cited by 12 publications

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“…A good discussion of the lipophilic and hydrophilic character of organic compounds is available . A quantitative analysis of lipophilic CENU drugs in plasma involved an ether extraction, conversion of the drugs to their O -methylcarbamate derivatives, and analysis of the latter by the GC−MS method.…”

Section: Assays Of Chemical and Biological Parameters Lipophilicity A...mentioning

confidence: 99%

A Critical Appraisal of the Evolution ofN-Nitrosoureas as Anticancer Drugs

1997

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Section: Assays Of Chemical and Biological Parameters Lipophilicity A...mentioning

confidence: 99%

A Critical Appraisal of the Evolution ofN-Nitrosoureas as Anticancer Drugs

1997

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Determination of 1-(2-chloroethyl)-3-(2,6-dioxo-3-piperidyl)-1-nitrosourea in plasma by negative chemical ionization mass spectrometry

Smith

Cheung

Feun

et al. 1983

Biol. Mass Spectrom.

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A sensitive and specific method for the quantitative determination of a new antitumor agent, 1-(2-chloroethyl)-3-(2,6-dioxo-3-piperidyl)-1-nitrosourea, (PCNU) has been developed for the analysis of plasma. This assay involves extraction of the plasma sample, separation of the drug by thin-layer chromatography and mass spectrometric detection of the negative ions derived from the unchanged drug and its 2H4-labeled analog. Ion current profile peaks are obtained when drug samples are introduced into the heated source using a desorption chemical ionization probe. Detection limits are below 1.0 ng ml-1 of plasma. This method has been applied to determine the in vitro rate of decomposition of PCNU in plasma and the plasma clearance of this drug from a cancer patient.

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