Quantitation of Mitral Regurgitation Using the Systolic/Diastolic Pulmonary Venous Flow Velocity Ratio

Seiler, Christian; Aeschbacher, Beat C.; Meier, Bernhard

doi:10.1016/s0735-1097(98)00090-4

Cited by 28 publications

(21 citation statements)

References 24 publications

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“…Absolute values of systolic and diastolic PV flow velocity and their ratio depend not only on diastolic LV properties, but also on other factors, such as mitral regurgitation, younger age, LV systolic function, etc. [33]. These confounders might limit the use of PV flow velocity in the assessment of LV diastolic dysfunction, particularly, in general population [33].…”

Section: Discussionmentioning

confidence: 99%

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Left ventricular diastolic function in relation to the urinary proteome: A proof-of-concept study in a general population

Zhang¹,

Staessen²,

Thijs³

et al. 2014

International Journal of Cardiology

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BackgroundIn previous studies, we identified two urinary proteomic classifiers, termed HF1 and HF2, which discriminated subclinical diastolic left ventricular (LV) dysfunction from normal. HF1 and HF2 combine information from 85 and 671 urinary peptides, mainly up- or down-regulated collagen fragments. We sought to validate these classifiers in a population study.MethodsIn 745 people randomly recruited from a Flemish population (49.8 years; 51.3% women), we measured early and late diastolic peak velocities of mitral inflow (E and A) and mitral annular velocities (e' and a') by conventional and tissue Doppler echocardiography, and the urinary proteome by capillary electrophoresis coupled with mass spectrometry.ResultsIn the analyses adjusted for sex, age, body mass index, blood pressure, heart rate, LV mass index and intake of medications, we expressed effect sizes per 1-SD increment in the classifiers. HF1 was associated with 0.204 cm/s lower e' peak velocity (95% confidence interval, 0.057–0.351; p = 0.007) and 0.145 higher E/e' ratio (0.023–0.268; p = 0.020), while HF2 was associated with a 0.174 higher E/e' ratio (0.046–0.302; p = 0.008). According to published definitions, 67 (9.0%) participants had impaired LV relaxation and 96 (12.9%) had elevated LV filling pressure. The odds of impaired relaxation associated with HF1 was 1.38 (1.01–1.88; p = 0.043) and that of increased LV filling pressure associated with HF2 was 1.38 (1.00–1.90; p = 0.052).ConclusionsIn a general population, the urinary proteome correlated with diastolic LV dysfunction, proving its utility for early diagnosis of this condition.

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Section: Discussionmentioning

confidence: 99%

“…[33]. These confounders might limit the use of PV flow velocity in the assessment of LV diastolic dysfunction, particularly, in general population [33]. On the other hand, we measured the difference in duration between the mitral A flow and AR.…”

Section: Discussionmentioning

confidence: 99%

Left ventricular diastolic function in relation to the urinary proteome: A proof-of-concept study in a general population

Zhang¹,

Staessen²,

Thijs³

et al. 2014

International Journal of Cardiology

View full text Add to dashboard Cite

show abstract

“…[33]. These confounders might limit the use of PV flow velocity in the assessment of LV diastolic dysfunction, particularly, in general population [33].…”

Section: Discussionmentioning

confidence: 99%

Left ventricular diastolic function in relation to the urinary proteome: a proof-of-concept study in a general population

Zhang

Staessen

Thijs

et al. 2014

Journal of the American Society of Hypertension

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a b s t r a c t a r t i c l e i n f oBackground: In previous studies, we identified two urinary proteomic classifiers, termed HF1 and HF2, which discriminated subclinical diastolic left ventricular (LV) dysfunction from normal. HF1 and HF2 combine information from 85 and 671 urinary peptides, mainly up-or down-regulated collagen fragments. We sought to validate these classifiers in a population study. Methods: In 745 people randomly recruited from a Flemish population (49.8 years; 51.3% women), we measured early and late diastolic peak velocities of mitral inflow (E and A) and mitral annular velocities (e' and a') by conventional and tissue Doppler echocardiography, and the urinary proteome by capillary electrophoresis coupled with mass spectrometry. Results: In the analyses adjusted for sex, age, body mass index, blood pressure, heart rate, LV mass index and intake of medications, we expressed effect sizes per 1-SD increment in the classifiers. HF1 was associated with 0.204 cm/s lower e' peak velocity (95% confidence interval, 0.057-0.351; p = 0.007) and 0.145 higher E/e' ratio (0.023-0.268; p = 0.020), while HF2 was associated with a 0.174 higher E/e' ratio (0.046-0.302; p = 0.008). According to published definitions, 67 (9.0%) participants had impaired LV relaxation and 96 (12.9%) had elevated LV filling pressure. The odds of impaired relaxation associated with HF1 was 1.38 (1.01-1.88; p = 0.043) and that of increased LV filling pressure associated with HF2 was 1.38 (1.00-1.90; p = 0.052). Conclusions: In a general population, the urinary proteome correlated with diastolic LV dysfunction, proving its utility for early diagnosis of this condition.

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“…Transthoracic images with sufficient quality to visualize at least one pulmonary vein can be obtained in 90% of patients by transthoracic echocardiography [30]. With transesophageal examination, at least one vein can be sampled in virtually every patient.…”

Section: Pulmonary Vein Flowmentioning

confidence: 99%

“…This is reflected in the decreased velocity of the pulmonary vein flow in systole. A ratio of the systolic to diastolic pulmonary vein flow velocity of >1 excludes severe MR [30]. The systolic The pulsed wave spectral envelope of pulmonary vein inflow pattern in a patient with severe mitral regurgitation.…”

Section: Pulmonary Vein Flowmentioning

confidence: 99%

Quantitative assessment of mitral insufficiency: Its advantages and disadvantages

Paszczuk

Wiegers

2006

Heart Fail Rev

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Quantitation of Mitral Regurgitation Using the Systolic/Diastolic Pulmonary Venous Flow Velocity Ratio

Abstract: The VTIs/VTId ratio allows a moderately accurate assessment of the severity of MR.

Cited by 28 publications

References 24 publications

Left ventricular diastolic function in relation to the urinary proteome: A proof-of-concept study in a general population

Left ventricular diastolic function in relation to the urinary proteome: A proof-of-concept study in a general population

Left ventricular diastolic function in relation to the urinary proteome: a proof-of-concept study in a general population

Quantitative assessment of mitral insufficiency: Its advantages and disadvantages

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