Quantitation of propofol in whole blood by gas chromatography—mass spectrometry

Guitton, Jérôme; Désage, M.; Lepape, Alain; Degoute, C. S.; Manchón, M.; Brazier, J. L.

doi:10.1016/0378-4347(95)00105-r

Cited by 48 publications

(39 citation statements)

References 8 publications

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“…Consciousness was regained after 8-10min at concentrations of 1-2.5µg/ml [19,20,21,22,23]. Thus the propofol blood concentration of 5.3µg/ml measured in our case is well within the range of the anaesthetically used concentrations during the institution of a narcosis, leading to the conclusion that death could have occured immediatly following the propofol injection.…”

Section: Discussionsupporting

confidence: 67%

Death after excessive propofol abuse

Iwersen‐Bergmann

Rösner

Kühnau

et al. 2001

International Journal of Legal Medicine

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Section: Discussionsupporting

confidence: 67%

Death after excessive propofol abuse

Iwersen‐Bergmann

Rösner

Kühnau

et al. 2001

International Journal of Legal Medicine

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“…The procedure of propofol analysis in blood/plasma/ blood cells resolves itself into the estimation of the amount of the drug in extracts from the mentioned biomaterials (Dawidowicz and Fijatkowska, 1996;Plummer, 1987;Guitton et al, 1995). The accuracy of the analysis depends, among other things, on the recovery degree of propofol in the extraction process.…”

Section: Discussionmentioning

confidence: 99%

The influence of blood sample storage time on the propofol concentration in plasma and solid blood elements

Dawidowicz

Fijałkowska

Nestorowicz

et al. 2001

Biomedical Chromatography

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In order to describe the changes of propofol concentration in whole blood and in its components during the blood storage we examined venous blood samples collected from patients anaesthetized either with or without propofol. Blood samples from patients anaesthetized without propofol were spike with propofol 45 min before analysis. Propofol concentration was examined in whole blood, plasma, rinsed formed elements and rinsed and lysed formed blood elements by means of HPLC after 1, 4, 7, 13, 21, 25 and 28 days of storage. There was significant decrease in plasma concentration of propofol during the first few days of sample storage followed by its increase during subsequent days. The opposite phenomenon was observed for formed blood elements. The findings support the hypothesis that propofol distribution between blood components changes in time.

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“…ence in the free propofol concentration (24 ng/ml) as compared with an unhydrolyzed sample, and thus no evidence for conjugated propofol metabolites. 3 Metoclopramide, which can cause green urine, 4 could not be detected in the breast milk sample. Green breast milk is described after iron intake.…”

Section: Green Breast Milk After Propofol Administrationmentioning

confidence: 98%

Green Breast Milk after Propofol Administration

Birkholz

Eckardt²,

Renner³

et al. 2009

Anesthesiology

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attenuation factor probably underestimates the acoustic exposure in fluid-filled tissue.A homogeneous tissue model with attenuation coefficient of 0.3 decibels/cm megahertz throughout the beam path is commonly used when estimating exposure levels. The model is conservative in that it overestimates the in situ acoustic exposure when the path between the transducer and site of interest is composed entirely of soft tissue. When the path contains significant amounts of fluid, as in many firstand second-trimester pregnancies scanned transabdominally, this mode may underestimate the in situ acoustic exposure. The amount of underestimate depends on each specific situation.

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Quantitation of propofol in whole blood by gas chromatography—mass spectrometry

Cited by 48 publications

References 8 publications

Death after excessive propofol abuse

Death after excessive propofol abuse

The influence of blood sample storage time on the propofol concentration in plasma and solid blood elements

Green Breast Milk after Propofol Administration

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