Quantitative 1H NMR method for hydrolytic kinetic investigation of salvianolic acid B

Pan, Jianyang; Gong, Xingchu; Qu, Haibin

doi:10.1016/j.jpba.2013.06.020

Cited by 16 publications

(18 citation statements)

References 19 publications

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“…However, remarkable deviation can be observed when degradation time was long [6]. The predicted Salvianolic acid B concentration value was lower than experimental results, which means that reverse reactions of Salvianolic acid B degradation cannot be neglected.…”

Section: Accepted Manuscriptmentioning

confidence: 72%

“…The degradation of Salvianolic acid B in aqueous solution was investigated by many researchers [6][7][8][9][10][11][12][13][14]. Danshensu, lithospermic acid, Salvianolic acid A, protocatechuic aldehyde, caffeic acid, Salvianolic acid E, Salvianolic acid D, and many other phenolic compounds are found to be the degradation products of Salvianolic acid B [7][8][9][10][11][12]15].…”

Section: Salvia Miltiorrhiza Danshen In Chinese Is a Medicinal And mentioning

confidence: 99%

“…3 irreversible reaction kinetics model was adopted to quantitatively describe the degradation of Salvianolic acid B [6,10,19]. However, remarkable deviation can be observed when degradation time was long [6].…”

Section: Accepted Manuscriptmentioning

confidence: 99%

“…The predicted Salvianolic acid B concentration value was lower than experimental results, which means that reverse reactions of Salvianolic acid B degradation cannot be neglected. The degradation reactions of Salvianolic acid E and lithospermic acid, which are two of Salvianolic acid B's degradation products, were also reported [6,11]. These reactions also need to be considered in the modeling of degradation kinetics of Salvianolic acid B to accurately calculate the effects of reverse reactions of Salvianolic acid B degradation.…”

Section: Accepted Manuscriptmentioning

confidence: 99%

“…Therefore, no oxidation products of Salvianolic acid B is considered in model building. In previous work, it is found that hydrolysis reactions of Salvianolic acid B and Salvianolic acid E are main degradation reactions [6]. Therefore, the degradation of Salvianolic acid B was simplified, as shown in Fig.…”

Section: Modeling Of Salvianolic Acid B Degradation In Industry Extrmentioning

confidence: 99%

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Modeling of degradation kinetics of Salvianolic acid B at different temperatures and pH values

Gong

Huang

Pan

et al. 2017

Chinese Journal of Chemical Engineering

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Section: Accepted Manuscriptmentioning

confidence: 72%

Section: Salvia Miltiorrhiza Danshen In Chinese Is a Medicinal And mentioning

confidence: 99%

Section: Accepted Manuscriptmentioning

confidence: 99%

Section: Accepted Manuscriptmentioning

confidence: 99%

Section: Modeling Of Salvianolic Acid B Degradation In Industry Extrmentioning

confidence: 99%

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Modeling of degradation kinetics of Salvianolic acid B at different temperatures and pH values

Gong

Huang

Pan

et al. 2017

Chinese Journal of Chemical Engineering

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Nuclear magnetic resonance using electronic referencing: method validation and evaluation of the measurement uncertainties for the quantification of benzoic acid in orange juice

Garrido

Carvalho

2014

Magnetic Reson in Chemistry

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Quantitative nuclear magnetic resonance measurements have become more popular over the last decade. The introduction of new methods and experimental parameters has been of fundamental importance in the development of new applications. Amongst these new developments is the introduction of electronic referencing for quantifications. The use of electronic referencing eliminates errors in the analyses as a result of weighting of internal standards as well as undesired problems as a result of the solubility of the standards in the analyte solution and chemical interactions between the analyte and the internal standard. In this work, we have studied the quantification of a very important analyte in a food matrix, benzoic acid in orange juice, as a model to the validation and measurement uncertainty estimation of electronic referencing using (1)H NMR in food analyses. The referencing method applied was the pulse length-based concentration measurement. Method was validated and showed good results for the precision and accuracy parameters evaluated. A certified reference material and a reference material candidate were analyzed, and extremely good results were obtained. Reported relative expanded uncertainties are in the 1.07-1.39% range that can be considered an extremely good performance for the analysis of a food complex matrix. Measurement uncertainty was evaluated by two different approaches, and the pulse calibrations for the samples and for the reference have been shown to account for approximately 80% of the total uncertainty of the measurement.

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Reaction Kinetics and Pathways for Salvianolic Acid B in High Temperature Water

Cheng

et al. 2018

ChemistrySelect

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A kinetic model for the production of salvianolic acid A (Sal A) from salvianolic acid B (Sal B) in high temperaturel water was proposed. The kinetic model includes the following key steps: (1) Sal B hydrolysis and decarboxylation to form salvianolic acid A (Sal A); (2) Sal B reversion/polymization to produce humins (polymerized insoluble carbonaceous species); (3) Sal A cyclization to form Sal C; (4) Sal A degradation to produce humins; (5) Sal C degradation to produce procatechuic aldehyde (PA) and danshensu (DSS). From kinetic analysis, relatively high temperatures are essential for maximum Sal A yield and relatively low temperatures are essential for maximum Sal C yield. The reaction model in this study can be used to predict the optimal production conditions for Sal A in the extraction reaction. Moreover, we also studied the extraction yields of Sal A from Salvia miltiorrhiza Bunge. The results showed that this method was suitable for production of Sal A, but there is no obvious advantage for production of Sal C.

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Quantitative 1H NMR method for hydrolytic kinetic investigation of salvianolic acid B

Cited by 16 publications

References 19 publications

Modeling of degradation kinetics of Salvianolic acid B at different temperatures and pH values

Modeling of degradation kinetics of Salvianolic acid B at different temperatures and pH values

Nuclear magnetic resonance using electronic referencing: method validation and evaluation of the measurement uncertainties for the quantification of benzoic acid in orange juice

Reaction Kinetics and Pathways for Salvianolic Acid B in High Temperature Water

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