Quantitative analysis of aqueous biomolecular mixtures by THz spectroscopy based on high-power LiNbO3 radiation source

Wang, Haiqing; Shi, Wei; Hou, Lei; Li, Chunhui; Wang, Zhiquan; Yang, Lei; Cao, Juncheng

doi:10.1016/j.saa.2022.122075

Cited by 3 publications

(1 citation statement)

References 21 publications

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“…The peak of 0.53 THz was identified as the absorption peak of α-lactose molecules, while the peak at 0.55 THz may have been caused by water vapor. However, the test environment was dry air with humidity lower than 3%, and previous high-power THz detections based on the sample cell had no interference of water vapor ( Wang et al, 2023 ). Therefore, it is speculated that the observed phenomenon was caused by the enhancement effect of ATR on the sample signal, and ATR is more sensitive than the sample cell.…”

Section: Resultsmentioning

confidence: 99%

Detection of the minimum concentrations of α-lactose solution using high-power THz-ATR spectroscopy

Wang

Shi

Hou

et al. 2023

Front. Bioeng. Biotechnol.

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Terahertz (THz) technology has emerged as a promising tool for the qualitative and quantitative identification of markers containing major diseases, enabling early diagnosis and staged treatment of diseases. Nevertheless, the detection of water-containing biological samples is facing significant challenges due to limitations in high-power THz radiation sources and high-sensitivity detection devices. In this paper, we present a designed and constructed set of Terahertz-Attenuated Total Reflection (THz-ATR) spectrometer for high-sensitivity detection of liquid biological samples, which can dynamically maintain the signal-to-noise ratio (SNR) of THz detection signal of liquid biological samples at 40–60 dB. Our high-power THz-ATR spectroscopy can identify and quantitatively detect α-lactose aqueous solution with a minimum concentration of 0.292 mol/L. Moreover, we observed that the rate of change in the absorption peak position varied greatly between high and low concentration samples. Our high-power, high-sensitivity THz-ATR spectroscopy detection provides a rapid, accurate, and low-cost method for detecting disease markers such as blood and urine indicators. Additionally, this approach offers new perspectives for the refinement and in-depth detection of biomedical samples.

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Section: Resultsmentioning

confidence: 99%

Detection of the minimum concentrations of α-lactose solution using high-power THz-ATR spectroscopy

Wang

Shi

Hou

et al. 2023

Front. Bioeng. Biotechnol.

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Terahertz Metamaterial Sensors: Design Theory, Optimization Approach, and Advancements in Biosensing Applications

Cao,

Jia,

Meng

et al. 2024

Adv Materials Technologies

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Metamaterials (MMs), distinguished by their unique electromagnetic properties, offer significant advantages in the realm of terahertz (THz) biosensing and early disease diagnosis. The intense electric field confined within subwavelength volumes in metallic MMs enhances the interaction between light and analytes. The Q‐factor, sensitivity and figure of merit (FOM) are three critical direct parameters for quantitative evaluation of sensor performance. Researchers are pursuing enhancement of these parameters by optimal design of MMs structures and dimensions as well as proper choice of materials. Recently, dielectric perturbation theory is quantitatively calculated and successfully utilized in the design and optimization of THz MMs sensors. Guided by this theory, this review focuses on the design principle of THz MMs sensors, the various study on how to improve the fundamental parameters of THz MMs sensors, the specific application in biosensing including the functionalization process, and the fabrication of THz MMs sensors. Based on these methods and results, the future development of THz sensors is finally presented in a perspective view.

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One-step precise machining of terahertz microstructures on chip-scale lithium niobate via laser dispersion engineering

Zhou

et al. 2023

Materials Today Physics

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Quantitative analysis of aqueous biomolecular mixtures by THz spectroscopy based on high-power LiNbO3 radiation source

Cited by 3 publications

References 21 publications

Detection of the minimum concentrations of α-lactose solution using high-power THz-ATR spectroscopy

Detection of the minimum concentrations of α-lactose solution using high-power THz-ATR spectroscopy

Terahertz Metamaterial Sensors: Design Theory, Optimization Approach, and Advancements in Biosensing Applications

One-step precise machining of terahertz microstructures on chip-scale lithium niobate via laser dispersion engineering

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