Quantitative analysis of bone mineral content by x-ray microtomography

Постнов, А. А.; Виноградов, А. В.; Dyck, D. Van; Saveliev, S. V.; Clerck, Nora M. De

doi:10.1088/0967-3334/24/1/312

Cited by 60 publications

(61 citation statements)

References 27 publications

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“…To examine the effects of exemestane treatment on whole bone parameters and on the trabecular bone in particular, right femora were analyzed by high-resolution X-ray micro-CT. Micro-CT has been shown to be well suited for the nondestructive visualization and quantitative analysis of bone and calcified tissue [20,21]. …”

Section: Experimental Designmentioning

confidence: 99%

Marginal Growth Increase, Altered Bone Quality and Polycystic Ovaries in Female Prepubertal Rats after Treatment with the Aromatase Inhibitor Exemestane

Gool

Wit²,

Schutter³

et al. 2010

Horm Res Paediatr

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Background: Aromatase inhibition has been proposed as a potential approach for growth enhancement in children with short stature, but detailed animal studies are lacking. Aim: To assess the effect and potential adverse effects of aromatase inhibition on growth in female rats. Methods: Prepubertal Wistar rats received intramuscular injections with placebo or the aromatase inhibitor exemestane at a dose of 10, 30 or 100 mg/kg/week (E10, E30, E100) for 3 weeks. A control group was ovariectomized (OVX). Weight and length gain, tibia and femur length, growth plate width, organ weights, insulin-like growth factor I (IGF-I) levels, and histology of the ovaries, uterus and brain were analyzed. X-ray microtomography of femora was performed. Results: E100 significantly increased weight gain and growth plate width, but less prominently than OVX. Trabecular number and thickness were decreased in E100 and OVX in the metaphysis and epiphysis. E100 significantly decreased ovarian weight and multiple cysts were seen upon histological evaluation. No significant effects were found on IGF-I levels and brain morphology in E100. E10 and E30 had no effects on growth. Conclusion: A high dose of exemestane marginally increases axial and appendicular growth in female rats, at the expense of osteopenia and polycystic ovaries.

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Section: Experimental Designmentioning

confidence: 99%

Marginal Growth Increase, Altered Bone Quality and Polycystic Ovaries in Female Prepubertal Rats after Treatment with the Aromatase Inhibitor Exemestane

Gool

Wit²,

Schutter³

et al. 2010

Horm Res Paediatr

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“…Degeneration of tissues in microgravity is a serious obstacle for long-term human stays in space or for interplanetary flights. It has been found that a stay under these conditions leads to bone demineralization (Postnov et al, 2003;Swinerd, 2008). Changes in the concentration of other heavier elements can also be expected.…”

Section: Introductionmentioning

confidence: 99%

Monochromatic computed microtomography using laboratory and synchrotron sources and X-ray fluorescence analysis for comprehensive analysis of structural changes in bones

et al. 2015

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A combination of X-ray tomography at different wavelengths and X-ray fluorescence analysis was applied in the study of two types of bone tissue changes: prolonged presence in microgravity conditions and age-related bone growth. The proximal tail vertebrae of geckos were selected for investigation because they do not bear the supporting load in locomotion, which allows them to be considered as an independent indicator of gravitational influence. For the vertebrae of geckos no significant differences were revealed in the elemental composition of the flight samples and the synchronous control samples. In addition, the gecko bone tissue samples from the jaw apparatus, spine and shoulder girdle were measured. The dynamics of structural changes in the bone tissue growth was studied using samples of a human fetal hand. The hands of human fetuses of 11-15 weeks were studied. Autonomous zones of calcium accumulation were found not only in individual fingers but in each of the investigated phalanges. The results obtained are discussed.

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“…Some researchers assume that X-ray absorption in the demineralized portion of bone is constant. 62 Similar assumptions can be made about the demineralized portion of dentin. Resin has been used by several authors as a soft tissue equivalent for the fabrication of radiographic phantoms, 55,[63][64][65] but the non-uniform distribution of powder during the mixing and resin curing processes 66 has resulted in grainy radiographic images.…”

Section: Measurements and Calibrationsmentioning

confidence: 94%

Theory of X-ray microcomputed tomography in dental research: application for the caries research

Park

Bae

Chang

et al. 2011

J Korean Acad Conserv Dent

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Caries remains prevalent throughout modern society and is the main disease in the field of dentistry. Although studies of this disease have used diverse methodology, recently, X-ray microtomography has gained popularity as a non-destructive, 3-dimensional (3D) analytical technique, and has several advantages over the conventional methods. According to X-ray source, it is classified as monochromatic or polychromatic with the latter being more widely used due to the high cost of the monochromatic source despite some advantages. The determination of mineral density profiles based on changes in X-ray attenuation is the principle of this method and calibration and image processing procedures are needed for the better image and reproducible measurements. Using this tool, 3D reconstruction is also possible and it enables to visualize the internal structures of dental caries. With the advances in the computer technology, more diverse applications are being studied, such automated caries assessment algorithms.

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Quantitative analysis of bone mineral content by x-ray microtomography

Cited by 60 publications

References 27 publications

Marginal Growth Increase, Altered Bone Quality and Polycystic Ovaries in Female Prepubertal Rats after Treatment with the Aromatase Inhibitor Exemestane

Marginal Growth Increase, Altered Bone Quality and Polycystic Ovaries in Female Prepubertal Rats after Treatment with the Aromatase Inhibitor Exemestane

Monochromatic computed microtomography using laboratory and synchrotron sources and X-ray fluorescence analysis for comprehensive analysis of structural changes in bones

Theory of X-ray microcomputed tomography in dental research: application for the caries research

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