Quantitative Analysis of C Cells in Hashimoto's Thyroiditis

Lima, Marcus Aurelho de; Santos, Benito Morgado; Borges, Maria F.

doi:10.1089/thy.1998.8.505

Cited by 19 publications

(12 citation statements)

References 11 publications

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“…Some authors have reported CCH in a number of thyroid specimens affected by Hashimoto's thyroiditis (Guyetant et al 1994). However, the association between thyroiditis and hypercalcitoninemia is still controversial (Karanikas et al 2004, Schuetz et al 2006 because some authors have reported decreased CT levels -in smaller groups of patients -that are probably caused by atrophy, fibrosis, and destruction of both follicular and C-cells (Body et al 1986, Borges et al 1998, Lima et al 1998, Poppe et al 1999. In addition to this, falsely high CT levels (or spurious hypercalcitoninemia) can be caused by the presence of heterophilic antibodies; this effect can be avoided through dilution techniques or sera pretreatment with blocking reagents (Giovanella & Suriano 2011).…”

Section: Introductionmentioning

confidence: 99%

Interpretation of serum calcitonin in patients with chronic autoimmune thyroiditis

Grani

Nesca²,

Sordo³

et al. 2012

Endocrine-Related Cancer

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Calcitonin (CT) is an important clinical marker for the diagnosis and follow-up of medullary thyroid carcinoma, although it is not absolutely specific. Some authors have reported C-cell hyperplasia in a number of thyroid specimens affected by Hashimoto's thyroiditis. The association between thyroiditis and hypercalcitoninemia is still controversial because some authors have reported low CT levels. The aim of this study is to evaluate the basal CT values in patients with and without thyroid autoimmunity. From May 2005 to February 2010, 1073 patients underwent ultrasonography-guided fine-needle aspiration cytology at the Thyroid Center of Sapienza University of Rome, with evaluation of basal serum FT4, FT3, TSH, and antithyroid peroxidase (anti-TPO) antibodies as well as CT levels. Forty-one patients presented a basal CT level above the reference upper limit. The mean serum CT was significantly lower in women than in men (4.28G6.63 vs 7.50G25.50 pg/ml; P!0.01). Basal serum CT was not significantly higher in patients showing anti-TPO Ab positivity (4.71G6.46 vs 4.84G13.11 pg/ml; PO0.05). Importantly, the rate of 'suspicious' CT values (above the 10 pg/ml cutoff) was not significantly different between patients with or without thyroid autoimmunity (3.9 vs 3.0%). Patients with hypercalcitoninemia suffering from chronic autoimmune thyroiditis should undergo the same clinical evaluation procedure as patients do without thyroid autoimmunity.

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Section: Introductionmentioning

confidence: 99%

Interpretation of serum calcitonin in patients with chronic autoimmune thyroiditis

Grani

Nesca²,

Sordo³

et al. 2012

Endocrine-Related Cancer

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“…The negative relationship between ECLIA-CT and TgAb in the present study suggested that CT level might be affected by HT. It has been reported that interference in measurement by antibodies or influence to C-cell by histological changes of thyroid gland induced by HT were possible mechanisms of the relationship [32][33][34][35].…”

Section: Discussionmentioning

confidence: 99%

Calcitonin levels by ECLIA correlate well with RIA values in higher range but are affected by sex, TgAb, and renal function in lower range

et al. 2020

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Calcitonin (CT) is a marker for both initial diagnosis and monitoring of patients with residual or recurrent medullary thyroid carcinoma (MTC). In Japan, serum CT had been measured by radioimmunoassay (RIA) until recently. Electrochemiluminescence immunoassay (ECLIA) became commercially available in 2014, and this technique is now the only method used to examine CT concentration. The purposes of this study were to investigate the correlations between the CT concentration measured with ECLIA (ECLIA-CT) and RIA (RIA-CT) and to explore the clinical characteristics of patients with elevated ECLIA-CT. CT concentrations of 348 sera samples from 334 patients with various thyroid disorders including nine MTC were measured using both assays. The correlation analysis revealed an excellent correlation between ECLIA-CT and RIA-CT among the cases with CT level >150 pg/mL by both assays (r s = 0.991, p < 0.001). However, 63% of all samples exhibited undetectable ECLIA-CT, while their RIA-CTs were measured between 15 and 152 pg/mL. The ECLIA-CTs in all patients who underwent total thyroidectomy for non-MTC showed low concentrations. High ECLIA-CT was observed in patients with MTC or pancreas neuroendocrine tumor. ECLIA-CT was also increased in 14 other male patients with non-MTC, including four with renal failure. Multivariate logistic regression analysis showed that male sex, negative TgAb, and lower estimated glomerular filtration rate were independent factors to predict detectable ECLIA-CT (≥0.500 pg/mL). These results indicate that ECLIA-CT correlates well with RIA-CT in higher range and is affected by sex, TgAb, and renal function.

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“…Diğer bir çalışmada TSH düzeyi 5-10 mU/L olan 87 çocuk üç yıl boyunca izleminde % 41'inin TSH düzeyi <5 mU/L, % 20'sinin 5-10 mU/L ve % 39'unun TSH düzeyinin >10 mU/L olduğu bildirilmiştir (27 (19). HT patogenezindeki inflamatuar süreçte kalsitonin salgılayan C hücrelerinin de etkilenebileceği ve bunun sonucunda HT'li hastalarda hipokalsemi oluşabileceği bildirilmiştir (30).…”

Section: Tiroid Antikorlarının Varlığı (Anti-tpo Ve Antitg)unclassified

Çocuk Ve Adolesanlarda Hashi̇moto Ti̇roi̇di̇ti̇ / Hashimoto Thyroiditis in Children and Adolescents

Binay¹,

Şimşek²

2016

Osmangazi̇ Journal of Medicine

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ÖZET: Hashimoto tiroiditi (HT) çocukluk yaş grubunda hipotiroidinin en sık sebebi olup guatr ya da atrofik tiroidit olarak karşımıza çıkabilir. Çeşitli hücre ve antikor aracılı immün sürece ve lenfositik infiltrasyona bağlı gelişen tiroid foliküllerinin harabiyeti ile karakterizedir. Etiyolojik olarak genetik yatkınlığı olan bireylerde çevresel faktörlerin etkisiyle ortaya çıktığı düşünülmektedir. HT tanısı serumda tiroid antijenlerine karşı gelişen (özellikle peroksidaz ve tiroglobulin) antikorların gösterilmesine dayanır. Ancak HT'li hastaların % 10-15'inde antikorlar negatif saptanabilir. Hastalar nonspesifik semptomlara sahip olup rutin tiroid fonksiyon testleri ile tanı alabilirler. HT değişken klinik prezentasyona sahiptir ve hastalar hipertiroid, hipotiroid veya ötiroid olabilir. Hipotiroidizm ile birlikte sık görülen semptomlar; halsizlik, soğuk intoleransı, konstipasyon, cilt kuruluğu, boy kısalığı ve kilo almadır. Klinik bulgular hipotiroidizmin derecesine bağlı olarak değişebilir. HT'de alopesi, vitiligo, çölyak hastalığı, addison hastalığı, tip 1 diyabet ve poliglandüler sendromlar gibi diğer otoimmün hastalıklar eşlik edebilir. HT tedavisinde klinik ve biyokimyasal olarak ötiroidiyi sağlamak amacıyla tiroid hormon replasmanı (levotiroksin) yapılmaktadır.. ANAHTAR KELIMELER: Hashimoto tiroiditi; adolesan; hipotiroidi; otoimmünite HASHIMOTO THYROIDITIS IN CHILDREN AND ADOLESCENTSABSTRACT: Hashimoto thyroiditis (HT) is the most common cause of hypothyroidism in pediatric age group resulting in either goiter or thyroid atrophy. It is characterized by the destruction of thyroid follicles by various cell-and antibody-mediated immune processes and lymphocytic infiltration. The etiology of HT is thought to be a combination of genetic susceptibility and environmental factors. The diagnosis of HT relies on the demostration of circulating antibodies to thyroid antigens mainly thyroperoxidase and thyroglobulin. However, 10-15 % of patients with HT may be antibody negative. Patients may have subclinical nonspecific symptoms, diagnosed based on routine screening of thyroid function. HT has a highly variable clinical presentation; patients may either be hyperthyroid, hypothyroid or euthyroid. Common presenting symptoms of hypothyroidism are fatigue, cold intolerance, constipation, dry skin, short stature and weight gain. Clinical findings may vary according to the extend of the hypothyroidism. HT is associated with other autoimmune diseases such as alopecia, vitiligo, coeliac disease, addison disease, type 1 diabetes and polyglandular syndrome. The treatment of HT is thyroid hormone replacement (levothyroxine) to restore a clinically and biochemically euthyroid state.

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Quantitative Analysis of C Cells in Hashimoto's Thyroiditis

Cited by 19 publications

References 11 publications

Interpretation of serum calcitonin in patients with chronic autoimmune thyroiditis

Interpretation of serum calcitonin in patients with chronic autoimmune thyroiditis

Calcitonin levels by ECLIA correlate well with RIA values in higher range but are affected by sex, TgAb, and renal function in lower range

Çocuk Ve Adolesanlarda Hashi̇moto Ti̇roi̇di̇ti̇ / Hashimoto Thyroiditis in Children and Adolescents

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