Quantitative analysis of cannabinoids and metabolites in oral fluid by volumetric absorptive microsampling combined with UHPLC-HRMS

Thiebot, P.; Magny, R.; Martins, P.; Houze, P.; Bloch, V.; Vorspan, F.; Auzeil, N.; Labat, L.

doi:10.1007/s00216-024-05651-9

Anal Bioanal Chem

2024

DOI: 10.1007/s00216-024-05651-9

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Quantitative analysis of cannabinoids and metabolites in oral fluid by volumetric absorptive microsampling combined with UHPLC-HRMS

P. Thiebot,

R. Magny,

P. Martins

et al.

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Cited by 1 publication

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Volumetric Absorptive Microsampling in Toxicology

Pires,

Catarro,

Soares

et al. 2024

Toxics

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Volumetric absorptive microsampling (VAMS) is an emerging technique in clinical and forensic toxicology. It is recognized as a promising alternative to traditional sampling methods, offering an accurate and minimally invasive means of collecting small volumes of biological samples, such as blood, urine, and saliva. Unlike conventional methods, VAMS provides advantages in terms of sample stability, storage, and transportation, as it enables samples to be collected outside laboratory environments without requiring refrigeration. This review explores several VAMS methodologies, with a particular focus on its application for the quantification of drugs and other substances in clinical and forensic toxicology. It compares VAMS to other microsampling techniques, such as dried blood spots (DBSs), highlighting VAMS’s superiority in addressing issues related to sample volume consistency and environmental impact. Despite its advantages, VAMS also presents certain limitations, including higher costs and difficulties in detecting underfilled samples. Overall, VAMS stands out as a microsampling technique with the potential to enhance patient compliance and operational efficiency, positioning itself as a viable tool for toxicological analysis in both clinical and forensic contexts.

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Volumetric Absorptive Microsampling in Toxicology

Pires,

Catarro,

Soares

et al. 2024

Toxics

View full text Add to dashboard Cite

show abstract

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Quantitative analysis of cannabinoids and metabolites in oral fluid by volumetric absorptive microsampling combined with UHPLC-HRMS

Cited by 1 publication

References 52 publications

Volumetric Absorptive Microsampling in Toxicology

Volumetric Absorptive Microsampling in Toxicology

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