Quantitative analysis of dendrites from transplanted neostriatal neurons

Zemanick, Mark C.; Walker, Paul D.; McAllister, James P.

doi:10.1016/0006-8993(87)91336-9

Cited by 16 publications

(2 citation statements)

References 15 publications

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“…A similar dendritic immaturity has been reported for grafted neostriatal neurons which also possess a reduced density of dendritic spines even after many months of maturation in the host brain [DiFiglia et al, 1988;Walsh et al, 1988;Wilson et al, 1990b;Xu et al, 1992;Zemanick et al, 1987].…”

Section: Introductionmentioning

confidence: 61%

Postnatal Development of the Rat Neostriatum: Electrophysiological, Light- and Electron-Microscopic Studies

et al. 1998

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The postnatal development of the electrophysiological properties and morphology of rat neostriatum was studied using in vivo and in vitro intracellular recording and biocytin staining and light and electron microscopy. The principal neurons, the medium spiny neurons, were found to undergo a protracted postnatal development of their electrophysiological and morphological characteristics. Most of the intrinsic membrane properties of medium spiny neurons came to resemble those in the adult by the end of the 3rd postnatal week. Synaptic responses and spontaneous activity patterns in medium spiny neurons were dependent on the arrival and functional maturation of excitatory afferents from cortex and thalamus and did not become adult-like until the end of the 1st postnatal month.

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Section: Introductionmentioning

confidence: 61%

Postnatal Development of the Rat Neostriatum: Electrophysiological, Light- and Electron-Microscopic Studies

et al. 1998

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“…It has been shown that grafted cells differentiate into specific cell types with general morphological characteristics that are comparable to the normal (Woodward et al, 1977;Alvarado-Mallart and Sotelo, 1982; Kromer et al, 1983;McLoon and Lund, 1983;McAllister et al, 1985;Frotscher and Zimmer, 1986;Sharp et al, 1987;Sotelo and Alvarado-Mallart, 1987; Clarke et al, 1988;Farber et al, 1988;Helmet al, 1990; Sotelo et al, 1990). However, some studies have demonstrated significant deviations from normal, revealing a reduction of the density of dendritic branches (Woodward et al, 1977;McLoon and Lund, 1983; Wells et al, 1986;Robain et al, 1987) or spines (Zemanick et al, 1987;Helm et al, 1992;Xu et al, 1992).…”

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confidence: 99%

Morphological maturation of thalamic neurons as studied in fetal neural transplants

Cadusseau

Rapisardi

Peschanski

1994

J of Comparative Neurology

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This study attempts to determine whether fetal thalamic neuroblasts from rat embryos (embryonic age 15 days) labeled with horseradish peroxidase (HRP) can differentiate into their normal dendritic phenotype when transplanted as a cell suspension into a lesioned site in the adult somatosensory thalamus. The HRP labeling provided a Golgi-like staining of numerous neurons up to 12-14 days after transplantation. There were three main results. 1) As early as 2 days after transplantation three morphologic cell types were observed: Two were bipolar and the third multipolar. These cellular profiles are characteristic of adult ventroposterolateral, reticular, and ventroposteromedial neurons and suggest that transplanted neurons can take shape in the absence of specific arrangements of afferent fibers. 2) The initial stage of dendritic growth was characterized by numerous growing specializations and consisted of a rapid, arborizing growth that appeared to proceed at an accelerated rate relative to normal development. During the later stage, which was characterized by the great reduction of growing specializations, dendritic remodeling resulted in a simpler morphology, and the transplanted neurons did not achieve an adult morphology. 3) Putative axons exhibiting growth cones were present in impressive densities in the transplants, and a number of them grew into the neuron-depleted host thalamus. A very small number of axons grew into host gray matter outside the lesioned area, indicating that neurodegenerative areas provide a better substrate for neurite outgrowth than intact tissue. In rare instances axons were visible in the internal capsule, indicating that the biochemical inhibition provided by mature myelin and oligodendrocytes may not be an absolute obstacle to axonal growth.

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Excitotoxic Lesions of the Neostriatum as an Animal Model of Huntington’s Disease

Emerich¹,

Cahill

Sanberg

1994

Toxin-Induced Models of Neurological Disorders

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Quantitative analysis of dendrites from transplanted neostriatal neurons

Cited by 16 publications

References 15 publications

Postnatal Development of the Rat Neostriatum: Electrophysiological, Light- and Electron-Microscopic Studies

Postnatal Development of the Rat Neostriatum: Electrophysiological, Light- and Electron-Microscopic Studies

Morphological maturation of thalamic neurons as studied in fetal neural transplants

Excitotoxic Lesions of the Neostriatum as an Animal Model of Huntington’s Disease

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