Quantitative analysis of doxorubicin hydrochloride and arterolane maleate by mid IR spectroscopy using transmission and reflectance modes

Bansal, Ranju; Singh, Ranjit; Kaur, Khushpal

doi:10.1186/s13065-021-00752-3

Cited by 59 publications

(20 citation statements)

References 22 publications

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“…These interactions are due to the electrostatic interaction between the doxorubicin with Pluronic-F127 molecules. The characteristic curve for doxorubicin was observed at 3453 cm -1 which was similar to the results obtained in previous works of literature, 32 and the FTIR spectra obtained for Pluronic-F127 were relatively similar to those obtained in other literature. 33 Despite the potential of nanocarriers in therapeutics, their applications are restricted by their interactions with the mononuclear phagocyte system (MPS) which leads to quick clearance.…”

Section: Discussionsupporting

confidence: 90%

Formulation, Characterization, and Evaluation of Doxorubicin-loaded Cubosome as a Cytotoxic Potentiator against HCT-116 Colorectal Cancer Cells

Almoshari¹,

Alam²,

Bakkari³

et al. 2022

IJPER

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Background: Colorectal cancer (CRC) has grown to be the world's fourth-biggest cause of cancer-related mortality. It is critical to identify more effective treatment options for it. Objectives: Doxorubicin a potent antineoplastic agent is widely used but has severe adverse effects. Therefore, our objective is to use cubosome as an efficient drug delivery system to reduce the off-target effects and increase the cytotoxic effects in CRC cells. Materials and Methods: Pluronic F127-Based Cubosomes were prepared by low energy stirring method and loaded with doxorubicin. Physicochemical characteristics were studied using X-ray diffraction, dynamic light scattering, microscopic techniques, FTIR UV spectrophotometer, and entrapment efficiency. In vitro activity of doxorubicin-loaded cubosomes was studied on HCT-116 cells. Results: The prepared cubosomes have the required nano-size and the FTIR results showed the presence of both doxorubicin and Pluronic F-127. The entrapment efficiency of doxorubicin was high too. DOX-CBs have a better cytotoxic effect and induced ROS and reduced NO levels in HCT-116 cells. Conclusion:The obtained results show that doxorubicin-loaded cubosomes can be used to increase the cytotoxic effect in CRC cells and can be used with other chemotherapeutic agents.

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Section: Discussionsupporting

confidence: 90%

Formulation, Characterization, and Evaluation of Doxorubicin-loaded Cubosome as a Cytotoxic Potentiator against HCT-116 Colorectal Cancer Cells

Almoshari¹,

Alam²,

Bakkari³

et al. 2022

IJPER

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“…FTIR spectrum of plain DOX confirmed the characteristics bands at 3567, 2960, 2863, 1726, 1579, 1070, 871 and 652 cm−1 for N–H stretch, C–H stretch, CH2 stretching, C = O stretch, C = C ring stretch, C–O–C stretch, C = H bend and C = C ring bend, respectively ( Fig. 3 a) [57] .…”

Section: Resultssupporting

confidence: 56%

Green decoration of graphene oxide Nano sheets with gelatin and gum Arabic for targeted delivery of doxorubicin

Hasanin¹,

Taha²,

Abdou³

et al. 2022

Biotechnology Reports

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“…The reason may be the formation of hydrogen bond due to the coupling of DOX weakening the C=O stretching vibration. Moreover, new peaks of the aromatic ring C=C stretches for DOX were observed at 1,560 and 1,515 cm -1 in DOX@NGO-BBN-AF750 ( 50 ). All the above FT-IR results establish the formation of DOX@NGO-BBN-AF750.…”

Section: Resultsmentioning

confidence: 98%

pH-responsive graphene oxide loaded with targeted peptide and anticancer drug for OSCC therapy

Gao

Zhao

et al. 2022

Front. Oncol.

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Oral squamous cell carcinoma (OSCC) is the most common type of cancer occurring in the oral and maxillofacial regions. Despite of the advances in the diagnosis and treatment, the overall 5-year survival rate has remained about 40%–50% in the past decades. Various nanotechnology-based carrier systems have been investigated for their potentials in the OSCC treatment. However, because of the lack of active targeting of tumors, their application is limited. Studies have shown that gastrin-releasing peptide receptors (GRPRs) are overexpressed on many human cancers, including head and neck squamous cell carcinoma. Herein, we aimed to develop a GRPR-targeted nano-graphene oxide (NGO) nanoprobe drug delivery system for OSCC therapy. DOX@NGO-BBN-AF750 was synthesized by the non-covalent bonding method to couple carboxylated NGO with BBN-AF750 (bombesin antagonist peptides conjugated to Alexa Fluor 750) and DOX (doxorubicin) through π-π and hydrogen bonding. Internalization and antitumor activities were carried out in human HSC-3 cancer cells. The tumor pH microenvironment was simulated to study the release of antitumor drug DOX from the DOX@NGO-ant BBN-AF750 complex under different pH conditions. DOX@NGO-BBN-AF750 showed internalization into HSC-3 cells. The IC50 (50% inhibitory concentration) was 5 µg/ml for DOX@NGO-BBN-AF750 in HSC-3 cells. Furthermore, DOX@NGO-BBN-AF750 showed a pH-sensitive drug release rate, and a dose-dependent and pH-responsive cytotoxicity in HSC-3 cells. DOX@NGO-BBN-AF750 presents the characteristics ensuring a slow release of DOX from the nanoprobe, thereby protecting the drug from degradation and prolonging the half-life of the drug. This report provides a versatile strategy to achieving targeted and imaging-guided therapy of OSCC.

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Quantitative analysis of doxorubicin hydrochloride and arterolane maleate by mid IR spectroscopy using transmission and reflectance modes

Cited by 59 publications

References 22 publications

Formulation, Characterization, and Evaluation of Doxorubicin-loaded Cubosome as a Cytotoxic Potentiator against HCT-116 Colorectal Cancer Cells

Formulation, Characterization, and Evaluation of Doxorubicin-loaded Cubosome as a Cytotoxic Potentiator against HCT-116 Colorectal Cancer Cells

Green decoration of graphene oxide Nano sheets with gelatin and gum Arabic for targeted delivery of doxorubicin

pH-responsive graphene oxide loaded with targeted peptide and anticancer drug for OSCC therapy

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