Quantitative analysis of internal components of the human crystalline lens during accommodation in adults

Xiang, Yan; Fu, Ting; Xu, Qiongfang; Chen, Wei; Chen, Zhiqi; Guo, Jingjie; Deng, Chaohua; Manyande, Anne; Wang, Ping; Zhang, Hong; Tian, Xiaojing; Wang, Junming

doi:10.1038/s41598-021-86007-6

Cited by 14 publications

(10 citation statements)

References 26 publications

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“…Table 3 summarises the mean radius of curvature for lens surfaces reported in the current study (converted from mean spherical powers of the surfaces), and from previous authors. [3][4][5][6][7][8][9]15,16,18,21,[31][32][33][34][35][36][37][38][39] Using phakometry, our anterior surface mean radius of curvature (mean 11.5 mm) is in the middle of the range reported in other phakometry studies [3][4]18,21,[38][39] (8.8-12.3 mm). However, the mean anterior curvature obtained using the IOLMaster 700 (14.1 mm) lies outside the upper limit of the range reported in other OCT studies [5][6][7][8][9][15][16]31 (11.0-13.1 mm).…”

Section: Discussionsupporting

confidence: 45%

“…[3][4][5][6][7][8][9]15,16,18,21,[31][32][33][34][35][36][37][38][39] Using phakometry, our anterior surface mean radius of curvature (mean 11.5 mm) is in the middle of the range reported in other phakometry studies [3][4]18,21,[38][39] (8.8-12.3 mm). However, the mean anterior curvature obtained using the IOLMaster 700 (14.1 mm) lies outside the upper limit of the range reported in other OCT studies [5][6][7][8][9][15][16]31 (11.0-13.1 mm). Our IOLMaster measurements of the model eye suggest that our measurements are slightly flat by ~3.3%.…”

Section: Discussionsupporting

confidence: 45%

“…Such techniques have been used to assess lens shape changes during accommodation, 3,4,8,9,[14][15][16] as well as with age and cycloplegia. 17,18 Most phakometry studies determine lens surface shape in a single meridian, or assume the surfaces are spherical.…”

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confidence: 99%

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Measurement of in vivo lens shapes using IOLMaster 700 B‐scan images: Comparison with phakometry

Pradhan,

Hughes,

Pieterse

et al. 2024

Ophthalmic Physiologic Optic

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PurposeThis study compared in vivo crystalline lens shape measurements using B‐scan images from the IOLMaster 700 with phakometry.MethodsTwenty‐four young adult participants underwent IOLMaster 700 and phakometry measurements under cycloplegia (1% cyclopentolate). The IOLMaster 700 generated B‐scan images along six meridians in 30° increments, which were analysed using custom MATLAB software to determine lens surface radii of curvature. Phakometry measurements were obtained using Purkinje images reflected from the lens surfaces.ResultsThe IOLMaster 700 image analysis method yielded a lower mean anterior lens surface spherical equivalent power (+6.20 D) than phakometry (+7.55 D); however, the two measurements were strongly correlated (R(21) = 0.97, p < 0.0001). The astigmatic power vectors (J0 and J45) for the anterior lens surface were significantly higher for the IOLMaster 700 measurements, with only J0 showing a significant moderate positive correlation (R(21) = 0.57, p = 0.005). For the posterior lens surface, the IOLMaster 700 measurements had a higher mean spherical power (+14.28 D) compared to phakometry (+13.70 D); however, a strong positive correlation (R(21) = 0.90, p < 0.0001) was observed. No significant correlations were noted for posterior lens surface astigmatic vectors (J0 and J45). The IOLMaster 700 estimates for the equivalent lens mean spherical power were slightly lower than those for phakometry, with a mean difference of −0.72 D, and both methods were positively correlated (R(21) = 0.94, p < 0.0001).ConclusionsThe findings demonstrate that IOLMaster 700 B‐scan image analysis technique provides similar estimates of lens surface powers to phakometry. These results highlight the potential of the IOLMaster 700 to provide measurements of lens shape, informing future research and clinical use.

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Section: Discussionsupporting

confidence: 45%

Section: Discussionsupporting

confidence: 45%

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Measurement of in vivo lens shapes using IOLMaster 700 B‐scan images: Comparison with phakometry

Pradhan,

Hughes,

Pieterse

et al. 2024

Ophthalmic Physiologic Optic

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“…Similar observations were qualitatively observed experimentally in imaging studies of the accommodating crystalline lens. 27 , 34 …”

Section: Discussionmentioning

confidence: 99%

Estimation of Crystalline Lens Material Properties From Patient Accommodation Data and Finite Element Models

de la Hoz,

Martinez-Enriquez,

Marcos

2023

Invest. Ophthalmol. Vis. Sci.

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Purpose The mechanical properties of the crystalline lens are related to its optical function of accommodation, and their changes with age are one of the potential causes for presbyopia. We estimated the mechanical parameters of the crystalline lens using quantitative optical coherence tomography (OCT) imaging and wavefront sensing data from accommodating participants and computer modeling. Methods Full-lens shape data (from quantitative swept-source OCT and eigenlens representation) and optical power data (from Hartmann–Shack wavefront sensor) were obtained from 11 participants (22–30 years old) for relaxed accommodation at infinity and –4.5 D accommodative demand. Finite element models of lens, capsular bag, zonulae, and ciliary body were constructed using measured lens geometry and literature data, assuming a 60-mN radial force. An inverse modeling scheme was used to determine the shear moduli of the nucleus and cortex of the lens, such that the simulated deformed (maximally stretched) lens matched the participant's lens at –4.5 D. Results The shear moduli of the nucleus and cortex were 1.62 ± 1.32 and 8.18 ± 5.63 kPa, on average, respectively. The shear modulus of the nucleus was lower than that of the cortex for all participants evaluated. The average of the two moduli per participant was statistically significantly correlated with age ( R 2 = 0.76, P = 0.0049). Conclusions In vivo imaging and mechanical modeling of the crystalline lens allow estimations of the crystalline lens’ mechanical properties. Differences between nuclear and cortical moduli and their dependency with age appear to be critical in accommodative function and likely in its impairment in presbyopia.

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“…This behavior differs from accommodation, where an increase in lens thickness (i.e., increase in the curvature of the anterior and posterior surfaces of the crystalline lens) leads to a shallower ACD, with the anterior lens surface accounting for most of the LT change. 80 , 81 An accommodative stimulus of 3 D has been reported to alter LT by +138 µm and, subsequently, ACD by –106 µm. 82 The most parsimonious explanation is that the diurnal changes of the crystalline lens primarily occur at the posterior surface, 4 which is compatible with the diurnal rhythm of VCD being in antiphase to LT.…”

Section: Discussionmentioning

confidence: 99%

Seasonal Variation in Diurnal Rhythms of the Human Eye: Implications for Continuing Ocular Growth in Adolescents and Young Adults

Nilsen

Gilson

Pedersen

et al. 2022

Invest. Ophthalmol. Vis. Sci.

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Purpose To investigate the diurnal rhythms in the human eye in winter and summer in southeast Norway (latitude 60°N). Methods Eight measures (epochs) of intraocular pressure, ocular biometry, and optical coherence tomography were obtained from healthy participants (17–24 years of age) on a mid-winter's day ( n = 35; 6 hours of daylight at solstice) and on a day the following summer ( n = 24; 18 hours of daylight at solstice). Participants wore an activity monitor 7 days before measurements. The epochs were scheduled relative to the individual's habitual wake and sleep time: two in the day (morning and midday) and six in the evening (every hour until and 1 hour after sleep time). Saliva was collected for melatonin. A linear mixed-effects model was used to determine significant diurnal variations, and a sinusoid with a 24-hour period was fitted to the data with a nonlinear mixed-effects model to estimate rhythmic statistics. Results All parameters underwent significant diurnal variation in winter and summer ( P < 0.002). A 1-hour phase advance was observed for melatonin and ocular axial length in the summer ( P < 0.001). The degree of change in axial length was associated with axial length phase advance ( R 2 = 0.81, P < 0.001) and choroidal thickening ( R 2 = 0.54, P < 0.001) in summer. Conclusions Diurnal rhythms in ocular biometry appear to be synchronized with melatonin secretion in both winter and summer, revealing seasonal variation of diurnal rhythms in young adult eyes. The association between axial length and seasonal changes in the phase relationships between ocular parameters and melatonin suggests a between-individual variation in adaptation to seasonal changes in ocular diurnal rhythms.

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Quantitative analysis of internal components of the human crystalline lens during accommodation in adults

Cited by 14 publications

References 26 publications

Measurement of in vivo lens shapes using IOLMaster 700 B‐scan images: Comparison with phakometry

Measurement of in vivo lens shapes using IOLMaster 700 B‐scan images: Comparison with phakometry

Estimation of Crystalline Lens Material Properties From Patient Accommodation Data and Finite Element Models

Seasonal Variation in Diurnal Rhythms of the Human Eye: Implications for Continuing Ocular Growth in Adolescents and Young Adults

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