Quantitative analysis of mitochondrial ATP synthesis

Randall, E. Benjamin; Hock, Marcus Ong Eng; Lopez, Rachel; Marzban, Bahador; Marshall, Collin; Beard, Daniel A.

doi:10.1016/j.mbs.2021.108646

Cited by 5 publications

(2 citation statements)

References 20 publications

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“…Lastly, modelling energetics can be useful, for instance, in some cases of HF, where there are abnormalities in how heart cells produce energy. Works such as that by Randall et al [ 227 ] show how to model cardiac energetics, but there is a missing link with whole-organ cardiac mechanics. With all these advances, we could better model representations of physiological conditions, including exercise.…”

Section: Discussionmentioning

confidence: 99%

Advancing clinical translation of cardiac biomechanics models: a comprehensive review, applications and future pathways

Rodero,

Baptiste,

Barrows

et al. 2023

Front. Phys.

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Cardiac mechanics models are developed to represent a high level of detail, including refined anatomies, accurate cell mechanics models, and platforms to link microscale physiology to whole-organ function. However, cardiac biomechanics models still have limited clinical translation. In this review, we provide a picture of cardiac mechanics models, focusing on their clinical translation. We review the main experimental and clinical data used in cardiac models, as well as the steps followed in the literature to generate anatomical meshes ready for simulations. We describe the main models in active and passive mechanics and the different lumped parameter models to represent the circulatory system. Lastly, we provide a summary of the state-of-the-art in terms of ventricular, atrial, and four-chamber cardiac biomechanics models. We discuss the steps that may facilitate clinical translation of the biomechanics models we describe. A well-established software to simulate cardiac biomechanics is lacking, with all available platforms involving different levels of documentation, learning curves, accessibility, and cost. Furthermore, there is no regulatory framework that clearly outlines the verification and validation requirements a model has to satisfy in order to be reliably used in applications. Finally, better integration with increasingly rich clinical and/or experimental datasets as well as machine learning techniques to reduce computational costs might increase model reliability at feasible resources. Cardiac biomechanics models provide excellent opportunities to be integrated into clinical workflows, but more refinement and careful validation against clinical data are needed to improve their credibility. In addition, in each context of use, model complexity must be balanced with the associated high computational cost of running these models.

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Section: Discussionmentioning

confidence: 99%

Advancing clinical translation of cardiac biomechanics models: a comprehensive review, applications and future pathways

Rodero,

Baptiste,

Barrows

et al. 2023

Front. Phys.

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show abstract

“…In mitochondria, electrons from reduced nicotinamide adenine dinucleotide (NADH) and flavin adenine dinucleotide (FADH2) produced in the tricarboxylic acid (TCA) cycle donate electrons to complex I (NADH dehydrogenase) and complex II (succinate dehydrogenase), respectively, while CoQ and cytochrome c shuttle electrons to complex III (cytochrome c reductase) and complex IV (cytochrome c oxidase) [ 4 ]. The generated proton gradient is then exploited by complex V, which phosphorylates ADP into ATP [ 5 ].…”

Section: Introductionmentioning

confidence: 99%

Mitochondrial Damage-Associated Molecular Patterns and Metabolism in the Regulation of Innate Immunity

Lyu,

Wang,

Huang

et al. 2023

J Innate Immun

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The innate immune system, as the host’s first line of defense against intruders, plays a critical role in recognizing, identifying, and reacting to a wide range of microbial intruders. There is increasing evidence that mitochondrial stress is a major initiator of innate immune responses. When mitochondria’s integrity is disrupted or dysfunction occurs, the mitochondria’s contents are released into the cytosol. These contents, like reactive oxygen species, mitochondrial DNA, and double-stranded RNA, among others, act as damage-related molecular patterns (DAMPs) that can bind to multiple innate immune sensors, particularly pattern recognition receptors, thereby leading to inflammation. To avoid the production of DAMPs, in addition to safeguarding organelles integrity and functionality, mitochondria may activate mitophagy or apoptosis. Moreover, mitochondrial components and specific metabolic regulations modify properties of innate immune cells. These include macrophages, dendritic cells, innate lymphoid cells, and so on, in steady state or in stimulation that are involved in processes ranging from the tricarboxylic acid cycle to oxidative phosphorylation and fatty acid metabolism. Here we provide a brief summary of mitochondrial DAMPs’ initiated and potentiated inflammatory response in the innate immune system. We also provide insights into how the state of activation, differentiation, and functional polarization of innate immune cells can be influenced by alteration to the metabolic pathways in mitochondria.

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Structural and functional diversity of mitochondria in vestibular/cochlear hair cells and vestibular calyx afferents

2022

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Quantitative analysis of mitochondrial ATP synthesis

Cited by 5 publications

References 20 publications

Advancing clinical translation of cardiac biomechanics models: a comprehensive review, applications and future pathways

Advancing clinical translation of cardiac biomechanics models: a comprehensive review, applications and future pathways

Mitochondrial Damage-Associated Molecular Patterns and Metabolism in the Regulation of Innate Immunity

Structural and functional diversity of mitochondria in vestibular/cochlear hair cells and vestibular calyx afferents

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