Quantitative Analysis of mRNA and Protein Expression Levels of Aldo-Keto Reductase and Short-Chain Dehydrogenase/Reductase Isoforms in the Human Intestine

Abstract

HSD, hydroxysteroid dehydrogenase; IBD, inflammatory bowel disease; LC-MS/MS, liquid chromatograph-tandem mass spectrometry; NGS, next-generation sequencing; P450s, cytochrome P450; SDR, short-chain dehydrogenase/reductase; TMM, trimmed mean of M-values; TPM, transcripts per million.

Cancer to Cataracts: The Mechanistic Impact of Aldo-Keto Reductases in Chronic Diseases

“…The expression pattern in the human intestine is markedly different from that in the human liver, where the AKR1C isoforms are primarily expressed. It is clear that AKRs have a more uniform distribution and expression throughout the alimentary canal and its associated organs compared to MDRs and SDRs [ 10 , 11 ]. As a result, they are major participants in performing redox reactions against many chemotherapeutic agents resulting in chemo resistant cancers.…”