Quantitative Analysis of Nail Polish Remover Using Nuclear Magnetic Resonance Spectroscopy Revisited

Hoffmann, Markus M.; Caccamis, Joshua T.; Heitz, Mark P.; Schlecht, Kenneth D.

doi:10.1021/ed085p1421

Cited by 16 publications

(18 citation statements)

References 17 publications

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“…Proton Nuclear Magnetic Resonance Spectroscopy has been utilized for both qualitative and quantitative analyses of organic mixtures [1][2][3][4][5], however, there is a lack of reliable exercises using qNMR with the purpose of educational instruction [6][7][8][9][10][11]. In order to combat this, this experiment has been designed for simple implementation of the qNMR methodology into undergraduate chemistry laboratory curriculums.…”

Section: Introductionmentioning

confidence: 99%

Application of Quantitative Proton Nuclear Magnetic Resonance Spectroscopy for the Compositional Analysis of Short Chain Fatty Acid Benzyl Ester Mixtures

D’Amelia¹,

Kimura²,

Nirode³

2019

WJCE

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Nuclear Magnetic Resonance (NMR) has become one of the cornerstones of instrumental analysis work done in chemistry laboratories. NMR is most powerful when used quantitatively, the technique of using NMR to quantify the concentration of an analyte is referred to as qNMR and proton NMR, in particular, is extremely useful in this pursuit to quantify organic compounds. In order to increase exposure to the quantitative and qualitative aspects of NMR in the undergraduate chemistry laboratory, we have created a qNMR experiment to be used in analytical chemistry and instrumental analysis courses. The objective of the experiment was to determine the % composition of a two-component mixture of benzyl acetate (BA), benzyl propionate (BP), and benzyl butyrate (BB). We report on the methodologies used to determine % BA, BP, and BB. Mixtures ranged from 100% to 20%. The results show a strong linear relationship relating known weight %'s with qNMR weight %'s and serves as confirmation of the quantitative utility of proton NMR as well as an educational tool for the undergraduate chemical laboratory.

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Section: Introductionmentioning

confidence: 99%

Application of Quantitative Proton Nuclear Magnetic Resonance Spectroscopy for the Compositional Analysis of Short Chain Fatty Acid Benzyl Ester Mixtures

D’Amelia¹,

Kimura²,

Nirode³

2019

WJCE

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“…Although proton nuclear magnetic resonance ( 1 H NMR) spectroscopy is utilized for both qualitative and quantitative analyses of organic mixtures [1,2,3,4], there is a relatively limited number of quantitative experiments that can also be used as instructional exercises for undergraduate students [5,6,7,8,9]. The following 1 H NMR experiment was designed to support implementation of qualitative and quantitative NMR methodology in the undergraduate chemistry laboratory curriculum.…”

Section: Introductionmentioning

confidence: 99%

Application of <SUP>1</SUP>H-NMR for the Quantitative Analysis of Short Chain Fatty Acid Methyl Ester Mixtures: An Undergraduate Instrumental Analysis Experiment

D’Amelia¹,

Huang²,

Nirode³

et al. 2015

WJCE

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Nuclear magnetic resonance spectroscopy (NMR) is one of the most important instrumental techniques used to elucidate the molecular structure of organic compounds. However, there are not many good simple applications of using NMR for the quantitative assay of impure or mixtures of organic substances. The current experiment was developed as part of an ongoing effort to increase exposure to quantitative proton NMR methodology in the undergraduate chemistry laboratory curriculum. The objective of the experiment is to determine the percent composition of a two component mixture of short chain fatty acid methyl esters using chemical shift and integration values obtained from running solvent-less samples both with and without an internal reference standard. We report on the experimental methods and results obtained from examining the quantitative NMR properties of a series of mixtures of methyl acetate (M.A.) and methyl propionate (M.P.) solutions ranging from 100% MA to 100% MP. Also similar data was obtained for the MA -methyl butyrate (MB) pair. The results exhibit a linear relationship of the percent composition of the methyl acetate binary mixtures found by proton NMR with the theoretical (i.e. samples prepared based on measured weights) percent compositions. The experiment confirms the quantitative usage of 1 H NMR and serves as an educational tool for the undergraduate chemical laboratory.

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“…However, as long as phasing and baseline correction are done carefully, and there is a reasonable signal-to-noise ratio and digital resolution, precision can be better than that. In fact, variation of sample tubes from the same (batch of) vendor is also extremely minimum, and quantitative analyses through calibration curves (Clarke, 1997) or standard addition methods are quite reliable (Hoffmann et al, 2008a). For such quantitative analysis across several different samples, it is imperative to record spectra with identical settings for receiver gain, number of scans, and so on, and the relaxation delay needs to be set long enough for complete recovery.…”

Section: Data Analysis and Initial Interpretationmentioning

confidence: 99%

Nuclear Magnetic Resonance: Basic Principles and Liquid State Spectroscopy

Hoffmann

2012

Characterization of Materials

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Thermogravimetric analysis (TGA) is an analytical technique for measuring changes in the mass of a material that occur in response to programmed temperature changes. The changes in the mass can be caused by a variety processes such as decomposition, degradation, sublimation, vaporization, adsorption, desorption, oxidation, and reduction. The article explains the principles of TGA and practical aspects of the method that include description of the apparatus, discussion of experimental variables, and applications. Among practical applications, a particular attention is paid to determining composition and thermal stability of materials, evaluating the kinetics of thermally stimulated processes, predicting lifetimes, and studying reactions of materials with gases. The article also addresses the issues of sample preparation as well as of basic analysis and interpretation of data. A special consideration is given to the sources of errors in the mass and temperature measurements as well as to the methods of calibrating both values.

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Quantitative Analysis of Nail Polish Remover Using Nuclear Magnetic Resonance Spectroscopy Revisited

Cited by 16 publications

References 17 publications

Application of Quantitative Proton Nuclear Magnetic Resonance Spectroscopy for the Compositional Analysis of Short Chain Fatty Acid Benzyl Ester Mixtures

Application of Quantitative Proton Nuclear Magnetic Resonance Spectroscopy for the Compositional Analysis of Short Chain Fatty Acid Benzyl Ester Mixtures

Application of <SUP>1</SUP>H-NMR for the Quantitative Analysis of Short Chain Fatty Acid Methyl Ester Mixtures: An Undergraduate Instrumental Analysis Experiment

Nuclear Magnetic Resonance: Basic Principles and Liquid State Spectroscopy

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